Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Global Study Discovers Flurry of New Alzheimer’s Genes

Published: Wednesday, October 30, 2013
Last Updated: Wednesday, October 30, 2013
Bookmark and Share
An international study has uncovered 11 new genes that increase the chance of developing Alzheimer’s disease and provide new clues to ways of fighting it.

The study, which examined close to 75,000 people in 15 countries, doubles the number of known genes that increase Alzheimer’s risk in the elderly. “The international group identified as many new genes in this one study as have been found over the last 15 years combined,” says one of the study’s senior authors, Richard Mayeux, MD, chair of neurology at Columbia University Medical Center.

The study, which is being published in the Nov. issue of Nature Genetics, was conducted by dozens of researchers through the International Genomics of Alzheimer’s Project (IGAP), created in 2011.

None of the 11 new genes has as strong an  effect on Alzheimer’s as the APOE4 gene, which was linked to the disease in the 1990s. APOE4 accounts for about 20 percent of cases, while the strongest of the new genes accounts for, at most, 8 percent of cases.

The significance of the discovery lies instead in the number of possible new drug targets revealed by the study, including some that are involved in processes never before considered in Alzheimer’s.

“Six of our new genes suggest the existence of new pathways underlying Alzheimer’s,” Mayeux says. These areas include the junction between neurons in the hippocampus, the area of the brain where Alzheimer’s begins, and the activity of other cells in the brain surrounding the neurons.

Other new genes uncovered by the group are related to processes in the brain that are well-known contributors to Alzheimer’s, including the processes that lead to the build-up of toxic amyloid beta and tau deposits, or help confirm newer ideas such as inflammation. The identification of new genes involved in these processes may ultimately lead to new drugs.

What’s most needed now, the investigators say, is an intense effort to understand the precise roles of all 22 genes in the development of Alzheimer’s disease.

“At the end of the day, we want to find a way to halt or prevent the disease,” Mayeux says.  “The prospects of doing this are now somewhat greater, but we still have a lot of work to do.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Haploid Embryonic Stem Cell Line
The haploid stem cells may yield new genetic screening tools and therapies.
Thursday, March 17, 2016
Useful Colon Cancer Biomarker Discovered
Biomarker is detectable with simple, inexpensive test.
Monday, January 25, 2016
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Thursday, November 26, 2015
Test Could Identify Which Prostate Cancers Require Treatment
3-gene biomarker gauges tumor’s aggressiveness.
Thursday, September 12, 2013
New Prenatal Gene Test Proposed as Standard of Care
Findings Published in NEJM show that microarray finds significantly more clinically relevant information than current method.
Thursday, December 06, 2012
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Gene Terapy for Muscle Wasting Developed
New gene therapy could save millions of people suffering from muscle wasting disease.
Mutations in DNA-Repair Genes Found in Advanced Prostate Cancers
New findings indicate that nearly 12% of male advanced prostate cancer sufferers have inherited mutation in DNA-repair genes.
Molecule May Affect Gaucher, Parkinson's Disease
Research has identified a molecule that restores activity of a dysfunctional enzyme linked to Gaucher and Parkinson's disease.
Targeting BRAF Mutations in Thyroid Cancer
Treating metastatic thyroid cancer patients harboring a BRAF mutation with vemurafenib showed anti-tumor activity in a third of patients.
Plant Compounds Fight Together Against Colon Cancer
Research shows treating colon cancer cells with curcumin, then silymarin is more effective than treatment with each individually.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Drug Candidates Reduce Abnormal Protein Production
New drug candidates improve cell ability to catch miss-folded proteins that could cause deadly diseases.
Supercomputing and Drug Discovery
New biotech company uses supercomputer simulations to speed up drug discovery and biotech molecule development.
Preventing Breast Cancer with Hops
Study of hops extract suggests prevention of breast cancer through chemical pathway activation.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!