Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Phasefocus Announces the Availability of the VL Series of Live Cell Imaging Systems

Published: Wednesday, February 05, 2014
Last Updated: Wednesday, February 05, 2014
Bookmark and Share
A family of phase microscopy systems for live cell imaging.

Phase Focus Ltd has announced a family of innovative phase microscopy systems for live cell imaging using the Phasefocus Virtual Lens®.

The Virtual Lens, VL, acquisition and processing engine uses a technique known as ptychography, to provide quantitative, high contrast, label-free images of cells for long term time-lapse studies.

The use of fluorescent probes is commonplace for labelling fixed specimens. However, when used in living cells, these can be toxic and ultimately perturb the natural cell function. The use of laser illumination can also be phototoxic to cells.

The Phasefocus VL20 upright and VL21 inverted live cell imaging systems use very low power laser illumination thereby enabling long term time-lapse cell imaging, including multi-area time-lapse, to produce high contrast quantitative image information.

In addition to this, the quantitative nature of the phase information means that data such as cell thickness, cell volume, and cell motility can be measured on a familiar and easy-to-use system for the study of both individual cells and cell populations.

The Virtual Lens is based on technology developed at the University of Sheffield by Professor John Rodenburg. It provides an iterative solution of the diffraction pattern phase problem and is applicable to visible light imaging, X-ray imaging and atomic resolution electron imaging.

Phasefocus has applied the technology to develop and install two systems at the University of York in the Department of Biology as one of many technology-leading techniques in the Imaging and Cytometry group managed by Dr Peter O'Toole.

Dr O'Toole describes ptychography as "one of the most important breakthroughs in imaging. It addresses many of the fundamental problems inherent in current microscopy techniques. Put simply, what you get is more than what you see! Artefacts of sample preparation which may arise from labelling or use of markers are negated. I have been most impressed by Phasefocus and their ability to quickly respond to feedback and then to develop products to meet the needs of the user."

In conjunction with the development of the Virtual Lens, Phasefocus is supporting a KTP Associate at York, - Dr Rakesh Suman - who works in Dr O'Toole's group tutoring members of the department in the use of the technique for the study of many different sample types including cancer and stem cells and applications relating to immunology and neurology.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Promising Class of New Cancer Drugs Cause Memory Loss in Mice
New findings from The Rockefeller University suggest that the original version of BET inhibitors causes molecular changes in mouse neurons, and can lead to memory loss in mice that receive it.
Electrical Control of Cancer Cells
Research led by scientists at The University of Texas Health Science Center at Houston (UTHealth) has revealed a new electrical mechanism that can control these switches.
Signature of Microbiomes Linked to Schizophrenia
Studying microbiomes in throat may help identify causes and treatments of brain disorder.
Inflammation Linked to Colon Cancer Metastasis
A new Arizona State University research study led by Biodesign Institute executive director Raymond DuBois has identified for the first time the details of how inflammation triggers colon cancer cells to spread to other organs, or metastasize.
Structural Discoveries Could Aid in Better Drug Design
Scientists have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output.
Determining the Age of Fingerprints
Watch the imprint of a tire track in soft mud, and it will slowly blur, the ridges of the pattern gradually flowing into the valleys. Researchers have tested the theory that a similar effect could be used to give forensic scientists a way to date fingerprints.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
Researchers Publish Landmark “Basket Study”
Researchers from Memorial Sloan Kettering Cancer Center (MSK) have announced results from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients’ tumors rather than where their cancer originated.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!