Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
Become a Member | Sign in
Home>News>This Article

Measure Cells and Particles as Small as 0.2 Microns

Published: Monday, March 03, 2014
Last Updated: Thursday, March 13, 2014
Bookmark and Share
Beckman Coulter Life Sciences launched the Multisizer 4e COULTER COUNTER at Pittcon 2014.

The latest Multisizer 4e features a new 10-micron aperture that enables users to obtain accurate count, size and mass distribution for particles and cells ranging from 0.2 to 1,600 microns.  Digital Pulse Processing provides high-resolution analysis in as many as 400 channels for unparalleled performance in pharmaceutical quality control, bioprocessing and industrial applications.

Incorporating the latest technology and software advances, the Multisizer 4e with unique Digital Pulse Processing delivers dynamic size measurements in real time.  High-speed signal digitalization allows the use of various pulse parameters for more accurate cell and particle characterization.  Response is unaffected by particle color, shape, composition or refractive index. Biotech applications include monitoring of transfection, counting mitochondria, organelles and other intracellular components, and characterizing changes in cell size when changes are made to cultures.  In these applications the volumetric analysis of the Multisizer 4e provides a more accurate and informative measurement than measuring size alone.

“Counting sub-visible particles, measuring volume as well as count and size, monitoring hundreds of channels at once — all of these features provide analysts with a highly useful and versatile instrument,” said Matthew Rhyner, PhD, Particle Characterization senior global business manager at Beckman Coulter Life Sciences.  “The 4e is an important addition to the Multisizer line, and we look forward to the great work that will be done with it by our customers.”

Sub-visible particle capability means that pharmaceuticals can be analyzed for compliance with USP 788 guidelines, to ensure product cleanliness. Multisizer 4e is also compliant with 21 CFR Part 11.  Industrial applications range from ink toners to cosmetics, from environmental studies to the monitoring of filter efficiency, and many others.

Instrument operation is completely computer controlled, and intuitive software with wizards and menu driven set-up assists both beginners and experienced users.  Sample management system using Smart Technology provides consistency from one analysis to the next.

The Multisizer 4e is the newest member of the COULTER COUNTER product family and the latest advancement in a long line of cell counting and sizing instruments. Since 1956, when the first COULTER COUNTER Model A was released, there have been 58 years of successful innovation using the COULTER Principle, making Beckman Coulter one of the leading companies in particle characterization today.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Beckman Coulter Life Sciences Features Genomic, Cellular Solutions at SLAS2013
Workshops, exhibit complemented by Biomek 4000 Workstation grant contest.
Wednesday, January 09, 2013
New Detection Cartridges Expand Applications of Beckman Coulter’s PARADIGM Platform
Beckman Coulter® introduces four detection cartridges for the PARADIGM Detection Platform, its modular plate reader, adding new capabilities for widely used fluorescence and luminescence applications.
Thursday, September 24, 2009
Automation Set to Boost Global Monoclonal Antibody Production
Abcam plc. and Beckman Coulter, Inc. have announced a major bioscience collaboration – to create one of the world’s most sophisticated, automated systems for the production of monoclonal antibodies for use in research.
Monday, December 24, 2007
Beckman Expands Automated Solutions for Biomedical Research
Beckman Chooses Motoman industrial robot arm for integration with the company’s automated liquid handling solutions.
Tuesday, January 24, 2006
Oxford Symposium Spotlights Beckman Coulter's ProteomeLab™ Technology
Beckman Coulter's ProteomeLab PF 2D provides an automated two-dimensional fractionation system.
Wednesday, November 23, 2005
Beckman Coulter Distribution Agreement With CRi

Friday, February 07, 2003
Beckman Coulter and Phenomenex to Co-Market HPLC Products

Tuesday, August 27, 2002
Scientific News
Promising Drug Candidate to Treat Chronic Itch
In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) describe a class of compounds with the potential to stop chronic itch without the adverse side effects normally associated with medicating the condition.
Are Changes to Current Colorectal Cancer Screening Guidelines Required?
Editorial suggests more research is needed to pinpoint age to end aggressive screening.
Assessing Cancer Patient Survival and Drug Sensitivity
RNA editing events another way to investigate biomarkers and therapy targets.
New Molecular Marker for Killer Cells
Cell marker enables prognosis about the course of infections.
Potential Target for Treatment of Autism
Grant of $2.4 million will support further research.
Sniffing Out Cancer
Scientists have been exploring new ways to “smell” signs of cancer by analyzing what’s in patients’ breath.
Inroads Against Leukaemia
Potential for halting disease in molecule isolated from sea sponges.
Molecular ‘Kiss Of Death’ Flags Pathogens For Destruction
Researchers have discovered that our bodies mark pathogen-containing vacuoles for destruction by using a molecule called ubiquitin, commonly known as the "kiss of death."
A New Single-Molecule Tool to Observe Enzymes at Work
A team of scientists at the University of Washington and the biotechnology company Illumina have created an innovative tool to directly detect the delicate, single-molecule interactions between DNA and enzymatic proteins.
Milestone Single-Biomolecule Imaging Technique May Advance Drug Design
The first nanometer resolved image of individual tobacco mosaic virions shows the potential of low-energy electron holography for imaging biomolecules at a single particle level; a milestone in structural biology and a potential new tool for drug design.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos