EU-OPENSCREEN - The European Research Infrastructure of Open Screening Platforms for Chemical Biology

EU-OPENSCREEN (www.eu-openscreen.eu) is the largest emerging academic chemical biology research infrastructure initiative in Europe with the aim to collaboratively develop novel research tool compounds with external scientists. As a joint effort of national networks in 16 European countries, EU-OPENSCREEN offers access to high-throughput screening platforms, chemistry services and a large compound collection. It invites biologists who have a robust and suitable biological assay to collaboratively develop chemical tool compounds to validate their targets-of-interest. Selected assays are screened against a collection of 100,000-200,000 compounds, incl. confirmatory and counter screening, IC/EC50 and SAR determination, and QC of confirmed hit compounds. Chemists are invited to provide compounds to be included into the jointly used EU-OPENSCREEN compound collection, which is screened against a wide range of biological assays, thereby delivering extensive information about the biological activities of their compounds. EU-OPENSCREEN adopts an open-access policy to support maximal data dissemination and publication.