Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>Products>This Product
  Products


IonWorks Barracuda Automated Patch Clamp System

Product Description
The IonWorks family of instruments targets the unmet need for a low cost, high throughput, direct electrophysiological assay for ion channel targets. Unlike indirect assays, such as fluorescent or ion flux assays, that are surrogate measure of ion channel activity, IonWorks instrumentation measures ionic currents directly and controls the membrane voltage inside a cell. The IonWorks® Barracuda™ System builds on the capabilities demonstrated by the IonWorks Quattro system while adding the capability to measure rapidly desensitizing ligand-gated channels. With the IonWorks Barracuda System a throughput of over 10,000 data points per day can be achieved with both voltage- and ligand-gated ion channels (VGICs and LGICs). The system features Population Patch Clamp (PPC) technology which improves data consistency and success rates by mitigating the biological variability seen when measuring from single cells. PPC has enabled the primary screening of large directed libraries as well as novel assays including channel opener assays and multiplexing multiple ion channel targets in a single assay. The IonWorks Barracuda System supports both PPC and single hole (SH) recording modes. SH recording mode is important where information must be obtained from individual cells during ion channel assay optimization and in applications such as the selection of individual clones for cell line optimization.

The IonWorks Barracuda System features a 384-well assay plate (our PatchPlate™ consumable) with a uniquely designed recording chamber that is optimized for rapid fluid exchange. This is especially important when measuring fast LGICs in order to resolve the rapid activation and desensitization kinetics of their ionic currents. The system combines 384 discreet amplifiers and a 384-channel pipettor head for the recording of ionic currents in all wells simultaneously. The parallel recording and fluidics configuration allow for the generation of over 10,000 data points per day. A typical ion channel assay with one compound addition per well can be completed in as little as 20 minutes. The system also allows up to eight compound additions per well further increasing the throughput and reducing the cost per data point. The IonWorks Barracuda System is ideal for primary screening of large directed compound libraries. Further, with the capability to add multiple compound additions per well, for example increasing concentrations on a dose response curve, the system is also well suited for compound profiling and safety assessment.
Product IonWorks Barracuda Automated Patch Clamp System
Company Molecular Devices Product Directory
Price Request a quote
More Information View company product page
Catalog Number Unspecified
Quantity Unspecified
Company Logo

Molecular Devices Product Directory
1311 Orleans Drive Sunnyvale, CA 94089-11361 United States

Tel: 1-800-635-5577
Fax: 1-408-548-6439
Email: om@moldev.com



Scientific News
Automated Patch Clamping Trends
Learn more about current practices, preferences and metrics in ion channel drug screening using APC technology.
Fly Study into Therapies for HVP-Induced Cancer
Fruit flies may help scientists understand the mechanism by which HPV can cause cancer as well as identify potential drug treatments.
World's Most In-Depth Study to Detect Alzheimer's Disease
A multisite team will see the most thorough and vigorous testing for Alzheimer's ever performed on volunteers.
'Missing Evolutionary Link' of Natural Drug Source Found
Scripps Florida study finds 'missing evolutionary link' of a widely used natural drug source
Grad Student's Finding Enables Rapid Compound Screening
Grad student makes technical leap that could enable rapid screening of anti-cancer compounds.
Uncovering Constructor Proteins
Scientists have discovered a new bacterial cell wall builder that could be a target for antibiotic development.
Cholesterol Linked to Aggressive Cancers
Research suggests fats, such as cholesterol, can increase aggressive cancer progression.
Biomarker Breakthrough Could Improve Parkinson’s Treatment
A new method of tracking Parkinson's progression could aid evaluation of new and experimental treatments to slow or stop the disease.
Targeting Neglected Diseases
New enzyme-mapping advancement could help drug development for combating diseases in the developing world.
How Parkinson’s Disease Alters Brain Activity Over Time
The NIH study provides a new tool for testing experimental medications aimed at alleviating symptoms and slowing the rate at which the diseases damage the brain.

SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!