Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>Products>This Product
  Products


MaxDiscovery™ Human IL-16 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-16 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-16 in serum, plasma, and cell culture supernatant. Human interleukin 16 (IL-16), known as lymphocyte chemoattractant factor (LCF), was originally identified as a homotetramer consisting of individual 14 kDa monomers of 130 amino acids each. It is synthesized as a 68 kDa precursor (pro-IL-16) of approximately 631 amino acids lacking a signal peptide. The human IL-16 sequence shows more than 90% homology to those of nonhuman primates. It is a unique cytokine with no significant sequence homology to other well-characterized cytokines or chemokines. IL-16 is produced by epithelial cells, mast cells, lymphocytes, macrophages, synovial fibroblasts, and eosinophils. IL-16 mRNA is constitutively expressed in both CD4+ and CD8+ cells; however, transcription is induced in T lymphocytes upon exposure to antigen or mitogen. IL-16 may also be secreted by activated CD8+ cells in response to histamine or serotonin. IL-16 expression has been linked to inflammation processes in asthma, rheumatoid arthritis, systemic lupus erythematosus, colitis, atopic dermatitis, and multiple sclerosis. For example, the expression of IL-16 directly correlates with the number of infiltrating CD4+ T cells in asthmatic epithelium. IL-16 is a proinflammatory cytokine with chemotactic for CD4+ T lymphocytes, monocytes and eosinophils. In addition, IL-16 can upregulate IL-2 receptor and HLA-DR expression, inhibit T cell receptor (TcR)/CD3-dependent activation and promote repression of HIV-1 transcription. Recombinant pro-IL-16 polypeptides are specifically cleaved in CD8+ cell lysates suggesting that the actual secreted form of IL-16 may be smaller than the originally published 130 amino acid form. In CD8+ T cells, active caspase-3 cleaves pro-IL-16 producing a biologically active, secreted form of IL-16 (i.e. representing 121 C-terminal amino acid residues of pro-IL-16). Expression of CD4 is required for mediating IL-16 functions. Interaction between IL-16 and CD4 can specifically initiate an increase in intracytoplasmic calcium and inositol trisphosphate, activation of p56lck, and translocation of protein kinase C from the cytosol to the cell membrane. The region of CD4 that binds IL-16 has been identified within the D4 domain, overlapping the structure involved in CD4 dimer formation.
Product MaxDiscovery™ Human IL-16 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2123-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122
Email: info@biooscientific.com



Scientific News
It’s Now Easier To Go With The Flow
Rice University tool simplifies comparison of flow cytometry data for laboratories.
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
Drugs that May Combat Deadly Antibiotic-Resistant Bacteria Uncovered
Study identifies 79 compounds that inhibit carbapenem-resistant Enterobacteriaceae (CRE).
Making Precision Medicine a Reality
Researchers are one step closer to understanding the genetic and biological basis of diseases like cancer, diabetes, Alzheimer’s and rheumatoid arthritis – and identifying new drug targets and therapies.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
MicroRNA Pathway Could Lead to New Avenues for Leukemia Treatment
Cancer researchers at the University of Cincinnati have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.
Soy Shows Promise as Natural Anti-Microbial Agent
Soy isoflavones and peptides may inhibit the growth of microbial pathogens that cause food-borne illnesses, according to a new study from University of Guelph researchers.
Doubling Down on Dengue
HMS researchers have discovered two ways a compound blocks dengue virus.
Soy Shows Promise as Natural Anti-Microbial Agent
Researchers from University of Guelph show that soy isoflavones and peptides could be used to reduce microbial contamination of food.
AstraZeneca to Sequence 2 Million Genomes in Search for New Drugs
Company launches integrated genomics approach which aims to transform drug discovery and development.

SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!