Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>Products>This Product
  Products


MaxDiscovery™ Human IL-17 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-17 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-17 in serum, plasma, and cell culture supernatant. Human interleukin 17 (IL-17) is a disulfide-linked homodimer with each ~ 17.5 kDa polypeptide of 136 amino acids (predicted mass = 17.5 kDa) after cleavage of a signal sequence of 19 amino acids. It contains six cysteines plus one potential N-linked glycosylation site, which is variably glycosylated, at least with recombinant proteins. It shares 63% and 58% sequence identity to those of mouse and rat, respectively and 72% identical to the thirteenth ORF of Herpesvirus saimiri. Originally identified as mouse cytotoxic T lymphocyte-associated antigen-8 (CTLA-8), IL-17 is produced by activated memory T lymphocytes. IL-17 appears to mediate communication between the immune system and the hematopoietic system. There is at least some species specificity for in vitro action on bone-marrow stromal cells. The IL-17 receptor (IL-17 R) from the mouse has been characterized. It is a 120 kDa type I transmembrane glycoprotein. There is neither an Ig-like domain nor the WSXWS motif of hematopoietin receptors in the 291 amino acid extracellular segment of the receptor, and there is no identifiable tyrosine kinase domain in the 521 residue cytosolic region. There are, however, serine-rich regions similar to those in IL-2 Rß, IL-4 R and G-CSF R. Thus, the receptor appears to be related to class I cytokine receptors. Based on cell line studies, IL-17 R is expressed by mast cells, fibroblasts, fetal hepatocytes, pre-B cells, and intestinal epithelial cells. It has been reported that IL-17 mediated T cell communication with the hematopoietic system. T cell-derived IL-17 induces fibroblasts to produce IL-6, IL-8, ICAM-1 and G-CSF, apparently by an NF-?B-mediated mechanism. IL-6 in turn promotes development of granulocyte/macrophage colonies, and G-CSF directs development of neutrophils. IL-17 also enhances proliferation of partially activated T cells and upregulates nitric oxide (NO) production in osteoarthritic cartilage. Selected Citations: Akhtar N., Verma, K. K., Sharma A. (Oct 2010) Study of pro- and anti-inflammatory cytokine profile in the patients with parthenium dermatitis Contact Dermatitis 63 (4): 203 – 208. Akhtar, N. et al (Dec 2010)Dysregulation of TH type cytokines in the patients of Parthenium induced contact dermatitis. Clinica Chimica Acta, 411 (23-24): 2024 - 2028.
Product MaxDiscovery™ Human IL-17 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2124-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122
Email: info@biooscientific.com



Scientific News
Breast Cancer Drug Hope
A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.
Harnessing Nature’s Vast Array of Venoms for Drug Discovery
Scripps scientists have developed a method for rapidly identifying venoms.
A New Platform for Discovering Antibiotics
Harvard chemists hope to shorten time, difficulty in measuring their effectiveness, potential.
The Need for Speed
Evaluating MALDI-TOF as a high-throughput screening technology for the pharmaceutical industry.
Antarctic Sponge Extract Kills MRSA
New findings may provide opportunity for developing new drugs to fight dangerous bacteria currently highly resistant to treatment.
US-India Collab Finds Molecular Signatures of Severe Malaria
Study may be a significant advancement in understanding the causes of severe malaria.
Novel Way to Prevent Deadly Bacterial Infections
Monash scientists may have found a way to stop deadly bacteria from infecting patients. The discovery could lead to a whole new way of treating antibiotic-resistant “superbugs”
Gene Expression Controls Revealed
Researchers have modelled every atom in a key part of the process for switching on genes, revealing a whole new area for potential drug targets.
An Old-New Weapon Against Emerging Chikungunya Virus
Researchers utilize existing drugs to interfere with host factors required for replication of Chikungunya virus.
Using Gene-editing Technology for Faster, Cheaper Antiviral Drug Development
UCLA scientists are working to develop special screening libraries based on a gene-editing technology called CRISPR.

SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!