The MaxDiscovery™ Human IL-1a ELISA Test Kit is designed for quantitative determination of the concentration of human IL-1a in serum, plasma, and cell culture supernatant. Human interleukin 1a (IL-1a) is a member of the interleukin 1 cytokine family. It is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. IL-1a is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.