Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>Products>This Product
  Products


MaxDiscovery™ Human IL-29 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-29 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-29 in serum, plasma, and cell culture supernatant. Human interleukin 29 (IL-29) is a cytokine distantly related to type I interferons and the IL-10 family. IL-29, interleukin 28A (IL-28A) and interleukin 28B (IL-28B), known as IFN?1, ?2, and ?3, are three closely related cytokine genes that form a cytokine gene cluster on chromosome 19. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor beta (IL-10Rß) and interleukin 28 receptor alpha (IL-28Ra). IFN?s are a novel family of interferons which mediate the induction of antiviral protection in a wide variety of cells. IFN?s share with type I IFNs an intracellular signaling pathway that drives the expression of a common set of IFN stimulated genes. IFN?s induce multiple biological activities, including the upregulation of class I MHC gene product expression to levels comparable to those induced by IFNa. Consistent with a role in antiviral protection, the mRNA expression of IFN? is detectable in cells infected with various viruses. Furthermore, monocytederived dendritic cells (important producers of IFNa) express IFN?1mRNA in response to treatment with dsRNA. TLR3 and TLR4 ligands induce IFNa, IFNß, IL-28, and IL-29 gene expression in macrophages. This is dependent upon IFNa. IFN? mediates its antiviral protection through a class II cytokine receptor complex distinct from that of type I IFNs. This is comprised of two essential receptor proteins, CRF212/IFN?R1, which is unique to IFN?, and CFR24/IL10R2, which is shared with IL10, IL22, and IL26 receptors. Whereas, the two chains of the type I IFN receptor (IFNAR1 and IFNAR2) and IL10R2 are ubiquitously expressed, IFN?R1 expression is limited and celltype dependent. IFN?R1 is not expressed by monocytes, but is upregulated during GMCSF/ IL4 induced differentiation of DCs from human monocytes, yielding iDCs which are fully responsive to IFN?. The IFN?s, IL28 and IL29, have recently been reported to prime dendritic cells to induce proliferation of Foxp3 bearing regulatory T cells. IFN? matured DCs express high levels of class I and II MHC gene products, but low levels of costimulatory molecules, and are able to specifically induce IL-2dependent proliferation of CD4+CD25+FOXP3+ T cell population with contact dependent suppressive activity on T cells.
Product MaxDiscovery™ Human IL-29 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2128-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122
Email: info@biooscientific.com



Scientific News
New Tool Uses 'Drug Spillover' to Match Cancer Patients with Treatments
Researchers have developed a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best "kinase inhibitor" to silence these dangerous genetic causes of disease.
HIV Susceptibility Linked to Little-Understood Immune Cell Class
High levels of diversity among immune cells called natural killer cells may strongly predispose people to infection by HIV, and may be driven by prior viral exposures, according to a new study.
Sweet Revenge Against Superbugs
A special type of synthetic sugar could be the latest weapon in the fight against superbugs.
Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support
A new study reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer.
Long-sought Discovery Fills in Missing Details of Cell 'Switchboard'
A biomedical breakthrough reveals never-before-seen details of the human body’s cellular switchboard that regulates sensory and hormonal responses.
Tracking Breast Cancer Before it Grows
A team of scientists led by University of Saskatchewan researcher Saroj Kumar is using cutting-edge Canadian Light Source techniques to screen and treat breast cancer at its earliest changes.
Zebrafish Reveal Drugs that may Improve Bone Marrow Transplant
Compounds boost stem cell engraftment; could allow more matches for patients with cancer and blood diseases.
DNA Damage Seen in Patients Undergoing CT Scanning
Along with the burgeoning use of advanced medical imaging tests over the past decade have come rising public health concerns about possible links between low-dose radiation and cancer.
The Light of Fireflies for Medical Diagnostics
EPFL scientists have exploited the light of fireflies in a new method that detects biological molecules without the need for complex devices and high costs.
Vital Protein in Healthy Fertilization Process Identified
Researchers at the National Institutes of Health have discovered a protein that plays a vital role in healthy egg-sperm union in mice.

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!