The MaxDiscovery™ Human IL-6 ELISA Test Kit is designed for quantitative determination of the concentration of human interleukin 6 (IL-6) in serum, plasma, and cell culture supernatant. IL-6 is a 20.5 kDa protein containing 184 amino acid residues. It is a multifunctional protein that plays important roles in host defense, acute phase reactions, immune responses, and hemotopoiesis. Synonyms for IL-6 include: B cell stimulatory factor-2 (BSF-2), hybridoma/plasmacytoma growth factor, hepatocyte stimulating factor, cytotoxic T cell differentiation factor and macrophage-granulocyte inducing factor 2A (MGI-2A). IL-6 is expressed by a variety of normal and transformed cells including T cells, B cells, monocytes/macrophages, carcinomas, sarcomas, and many more. In comparison with mouse IL-6, human IL-6 exhibits approximately 65% sequence homology at the nucleotide level, and 42% homology at the amino acid level. In contrast to its growth stimulatory actitivities, IL-6 is also a growth inhibitor for a number of leukemia and carcinoma cells lines. Selected Citations: Na, J. O. et al. (Dec, 2010) Impaired transport function of the left atrium and left atrial appendage in cryptogenic stroke patients with atrial septal aneurysm and without patent foramen ovale Eur J Echocardiogr 12 (2): 140-147. doi: 10.1093/ejechocard/jeq164 Tsui, K-H et al. (July, 2010) Mechanisms by which Interleukin-6 Regulates Prostate Specific Antigen Gene Expression in Prostate LNCaP Carcinoma Cells. J Andrology, 32: 383 - 393. doi: 10.2164/jandrol.109.009878. Shin, S. Y. et al., (April, 2011) Improved Endothelial Function in Patients with Atrial Fibrillation through Maintenance of Sinus Rhythm by Successful Catheter Ablation. J Cardiovasc Electr. 22 (4): 376 – 382.