The MaxDiscovery™ Human TRAIL/TNFSF10 ELISA Test Kit is designed for quantitative determination of the concentration of human TRAIL/TNFSF10 in serum, plasma, and cell culture supernatant. TNF-related apoptosis-inducing ligand (TRAIL), a tumor necrosis factor superfamily (TNFSF) member designated TNFSF10, is a 281 amino acid protein which lacks a signal peptide. It is a Type II transmembrane protein consisting 3 domains, a glycosylated C-terminal extracellular domain, a transmembrane domain, and a short N-terminal cytoplasmic domain. Like other members of the TNFSF, TRAIL also exists in a soluble form. It has a broad expression pattern in fetal and adult tissues and variably expressed in tumor cell lines. Both cell-surface and soluble TRAIL induce apoptosis in a variety of lymphoid and non-lymphoid tumor cell lines. These effects are mediated through binding TRAIL receptors 1 and 2 (TRAIL R1 and TRAIL R2). Since TRAIL is capable of preferentially inducing apoptosis in tumor cells over normal cells, it has become an exciting prospect as a cancer pharmaceutical.
Cytoskeleton Crew Findings confirm sugar's role in helping cancers survive by changing cellular architecture.Biomarker for Recurring HPV-Linked Oropharyngeal Cancers A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University. Valvena, GSK Sign New R&D Collaboration Valneva to supply process development services for EB66® -based Influenza vaccines. Light Signals from Living Cells Fluorescent protein markers delivered under high pressure.Cellular 'Relief Valve' A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.Genomic Signature Shared by Five Types of Cancer National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer. Cat Stem Cell Therapy Gives Humans Hope By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives. Crowdfunding the Fight Against Cancer From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
New Biomarker to Assess Stem Cells Developed A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.A Better Model for Parkinson's Scientists at EPFL solve a longstanding problem with modeling Parkinson’s disease in animals. Using newfound insights, they improve both cell and animal models for the disease, which can propel research and drug development.