The MaxDiscovery™ Mouse GM-CSF ELISA Test Kit is designed for quantitative determination of the concentration of mouse GM-CSF in serum, plasma, and cell culture supernatant. Mouse granulocyte/macrophage-colony stimulating factor (GM-CSF) is a 14 kDa protein that is believed to contain 124 amino acid residues based on its cDNA sequence. Evidence from several laboratories demonstrates that it is primarily produced by activated T cells and macrophages in mice. It is also produced by other cell types including endothelium and fibroblasts when stimulated by TNF, IL-1, IL-2, and IFN-?. GM-CSF stimulates growth of macrophages, granulocytes, and dendritic cells and it plays a pivotal role in the immune response in mice. There are membrane-bound and soluble forms of GM-CSF. Soluble GM-CSF is found in a complex associated with the extracellular matrix. Both forms function in the biological processes mentioned above. Recombinant GM-CSF synthesized in E. coli is nonglycosylated and is also biologically active.
Light Signals from Living Cells Fluorescent protein markers delivered under high pressure.Cellular 'Relief Valve' A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.Genomic Signature Shared by Five Types of Cancer National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer. Cat Stem Cell Therapy Gives Humans Hope By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives. Crowdfunding the Fight Against Cancer From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
New Biomarker to Assess Stem Cells Developed A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.A Better Model for Parkinson's Scientists at EPFL solve a longstanding problem with modeling Parkinson’s disease in animals. Using newfound insights, they improve both cell and animal models for the disease, which can propel research and drug development.Faster Drug Discovery? Startup develops more cost-effective test for assessing how cells respond to chemicals.Microalgae Make a Splash in the UK Cosmeceutical Market Scottish innovators have discovered an anti-viral and anti-inflammatory carbohydrate in microscopic algae (microalgae) which has huge potential to change the cosmetics market. Mechanism of Tumor Suppressing Gene Uncovered The most commonly mutated gene in cancer,p53, works to prevent tumor formation by keeping mobile elements in check that otherwise lead to genomic instability, UT Southwestern Medical Center researchers have found.