The MaxDiscovery™ Mouse IL-15 ELISA Test Kit is designed for quantitative determination of the concentration of mouse interleukin 15 (IL-15) in serum, plasma, and cell culture supernatant. Mouse IL-15 is a 14.5 kDa protein, previously designated as IL-T. It is a pleiotropic cytokine that is important for both innate and adaptive immune cell homeostasis, as well as peripheral immune function. Although IL-15 shares the common ? chain (?c) and IL-2/15Rß with IL-2 signaling, it utilizes private IL-15Ra for high affinity binding. IL-15 plays a pivotal role in the development, survival, and function of the NK cell lineage. It is required for the normal expansion and/or survival of nonclassical T cells and memory phenotype TCR-a/ß CD8+ T cells. It also plays a role in peripheral immune functions such as T lymphocyte trafficking, innate immune IFN- ? production, and host defense against infectious pathogens.