The MaxDiscovery™ Mouse IL-17 ELISA Test Kit is designed for quantitative determination of the concentration of mouse IL-17 in serum, plasma, and cell culture supernatant. Mouse interleukin 17 (IL-17) is an approximately 16 kDa polypeptide of 136 amino acids. It is derived from the precursor consisting of 155 amino acids after a 19 amino acid signal peptide is cleaved. Human IL-17 shows approximately 62.5% amino acid homology to mouse IL-17 and 58% amino acid homology to rat IL-17. Also known as CTLA-8, IL-17 is a T cell-derived hematopoietic cytokine. It was originally cloned from a T cell hybridoma produced by fusion of a mouse cytotoxic T cell clone and a rat T lymphoma. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8 and G-CSF production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kappa B, and co-stimulation of T cell proliferation.