The MaxDiscovery™ Mouse IL-1ß ELISA Test Kit is designed for quantitative determination of the concentration of mouse IL-1ß serum, plasma, and cell culture supernatant. Mouse mature interleukin-1ß (IL-1ß) is a 17 kDa protein cleaved from its precursor (a 33 kDa protein). Together with IL-1a, they are members of IL-1 gene family. It is produced by various cells, especially macrophages and T cells in mice. The IL-1ß is encoded by a gene family composed of IL-1a, IL-1ß, and IL-1Ra. When stimulated by other cytokine growth factors, mRNA of IL-1ß is present within 15 minutes and accumulates for 4 hours followed by a rapid fall that results in part from the synthesis of a transcriptional repressor as well as a decrease in mRNA half-life. IL-1ß plays a role in signal transduction through its receptor, IL-1R. IL-1ß is a converting enzyme which plays an important role in apoptosis through nitric oxide. Recombinant IL-1 ß has similar biological functions in response to cytokine stimulus. In addition, recombinant IL-1ß generated in E. coli is nonglycosylated and is biologically active.