The MaxDiscovery™ Mouse IL-2 ELISA Test Kit is designed for quantitative determination of the concentration of mouse IL-2 serum, plasma, and cell culture supernatant. Mouse interleukin 2 (IL-2) is a T cell-derived cytokine known to promote growth and differentiation of T cells and to have pleiotropic effects on many other leukocytes. IL-2 is rapidly secreted upon activation by naive T helper cells and certain subsets of memory cells. Mature mouse IL-2 is a 15.5 kDa protein containing 133 amino acid residues after several posttranslational processing. It is primarily produced by activated T and B cells and macrophages in mice. It is also produced by other cell types such as fibroblasts and CD24+ cells when stimulated by TNF-a, IL-1, IL-2 and IFN-?. Mouse IL-2 stimulates growth of macrophages, granulocytes, dendritic cells and other granulose cells. There are two kinds of IL-2, a membrane-bound form and a soluble form in a complex associated with the extracellular matrix. Both play biological functions based on research. In addition, recombinant IL-2 generated in E. coli is nonglycosylated but is biologically active.
Charting Kidney Cancer Metabolism Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.Insights into the Function of the Main Class of Drug Targets About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.Visualizing a Cancer Drug Target at Atomic Resolution Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.Honey’s Potential to Save Lives The healing powers of honey have been known for thousands of years. 3-D Printed Lifelike Liver Tissue for Drug Screening A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling. Cytoskeleton Crew Findings confirm sugar's role in helping cancers survive by changing cellular architecture.Biomarker for Recurring HPV-Linked Oropharyngeal Cancers A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University. Valvena, GSK Sign New R&D Collaboration Valneva to supply process development services for EB66® -based Influenza vaccines. Light Signals from Living Cells Fluorescent protein markers delivered under high pressure.Cellular 'Relief Valve' A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.