Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>Products>This Product
  Products


MaxDiscovery™ Mouse TNF-a ELISA Test Kit

Product Description
The MaxDiscovery™ Mouse TNF-a ELISA Test Kit is designed for quantitative determination of the concentration of mouse tumor necrosis factor alpha (TNF-a) in serum, plasma, and cell culture supernatant. TNF-a is a potent mediator of immune and inflammatory responses. It is produced by many activated cell types including monocytes, astrocytes, granulocytes, T and B lymphocytes, NK cells, keratinocytes, fibroblasts, and certain tumor cells. Activated cells initially express TNF-a as a transmembrane protein that associates to form homotrimeric complexes. After proteolytic cleavage, the extracellular region of membrane TNF-a sheds as a soluble homotrimer. Membrane and soluble TNF-a homotrimers are biologically active whereas monomeric TNF-a is not. The mature mouse TNF-a monomer contains 156 residues, has a predicted size of ~17 kDa, and contains one potential N-glycosylation site. TNF-a exerts its biological activities by binding and signaling through membrane type I and II TNF-a Receptors (TNFR I and TNFR II). Interestingly, TNF-a binds to soluble forms of TNFRI and TNFRII which are naturally shed by activated cells and can modulate biological activities of TNF-a. TNF-a exerts many regulatory influences on the activation, growth, and differentiation of leukocytes and other cells. For example, TNF-a can co-stimulate differentiation of activated T and B lymphocytes, upregulate the expressed levels of MHC class I and class II molecules by various cell types, and induce the expression of adhesion molecules by endothelial cells. TNF-a is selectively cytotoxic for some transformed cell lines and can exert cytotoxic effects against certain solid tumors. In vivo, TNF-a serves as a primary mediator in protective immune responses against microbial and viral pathogens. Interestingly, TNF-a has also been implicated as a central mediator in a number of pathologic responses including septic shock, cachexia, and autoimmune diseases.
Product MaxDiscovery™ Mouse TNF-a ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2001-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122
Email: info@biooscientific.com



Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Drug Candidates Reduce Abnormal Protein Production
New drug candidates improve cell ability to catch miss-folded proteins that could cause deadly diseases.
Supercomputing and Drug Discovery
New biotech company uses supercomputer simulations to speed up drug discovery and biotech molecule development.
Preventing Breast Cancer with Hops
Study of hops extract suggests prevention of breast cancer through chemical pathway activation.
Treatment Advancement for Gaucher and Parkinson's Diseases
NIH scientists identify molecule that may act as a possible treatment of neurological diseases.
Biomunex Confirms Optimal Properties and Activity of BiXAb® Antibodies
Biomunex‘s Plug-and-Play bispecific antibodies demonstrated excellent in vitro properties and in vivo activity positively differentiating their BiXAb platform from competing formats.
Liquid Biopsy Predicts Colon Cancer Recurrence
Scientists have used a genetic test that spots bits of cancer-related DNA circulating in the blood to accurately predict the likelihood of the disease’s return in some — but not all — of a small group of patients with early-stage colon cancer.
New Treatment for Rare Blood Cancers
Drug called midostaurin showed promise in an international clinical trial led by a Stanford physician.
Biomarker for Parkinson's Disease Found in Urine Samples
Protein identified as Parkinson's biomarker sourced from patient's stored frozen urine samples.
Testing for Malaria or Cancer at Home
Chemist develops tech to save lives in rural Africa.

SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!