Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
Become a Member | Sign in
Home>Products>This Product

MaxDiscovery™ Mouse TNF-a ELISA Test Kit

Product Description
The MaxDiscovery™ Mouse TNF-a ELISA Test Kit is designed for quantitative determination of the concentration of mouse tumor necrosis factor alpha (TNF-a) in serum, plasma, and cell culture supernatant. TNF-a is a potent mediator of immune and inflammatory responses. It is produced by many activated cell types including monocytes, astrocytes, granulocytes, T and B lymphocytes, NK cells, keratinocytes, fibroblasts, and certain tumor cells. Activated cells initially express TNF-a as a transmembrane protein that associates to form homotrimeric complexes. After proteolytic cleavage, the extracellular region of membrane TNF-a sheds as a soluble homotrimer. Membrane and soluble TNF-a homotrimers are biologically active whereas monomeric TNF-a is not. The mature mouse TNF-a monomer contains 156 residues, has a predicted size of ~17 kDa, and contains one potential N-glycosylation site. TNF-a exerts its biological activities by binding and signaling through membrane type I and II TNF-a Receptors (TNFR I and TNFR II). Interestingly, TNF-a binds to soluble forms of TNFRI and TNFRII which are naturally shed by activated cells and can modulate biological activities of TNF-a. TNF-a exerts many regulatory influences on the activation, growth, and differentiation of leukocytes and other cells. For example, TNF-a can co-stimulate differentiation of activated T and B lymphocytes, upregulate the expressed levels of MHC class I and class II molecules by various cell types, and induce the expression of adhesion molecules by endothelial cells. TNF-a is selectively cytotoxic for some transformed cell lines and can exert cytotoxic effects against certain solid tumors. In vivo, TNF-a serves as a primary mediator in protective immune responses against microbial and viral pathogens. Interestingly, TNF-a has also been implicated as a central mediator in a number of pathologic responses including septic shock, cachexia, and autoimmune diseases.
Product MaxDiscovery™ Mouse TNF-a ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2001-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122

Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
University of Edinburgh, Selcia Achieve Key Milestones in Drug Development Program
Scientists from the University of Edinburgh, working with Selcia, have successfully passed the 20-month milestone targets of a 30-month Wellcome Trust SDDi £2.5 million project to design novel treatments for sleeping sickness.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Potential Persistent Tuberculosis Treatment
Researchers have discovered several first-in-class compounds that target hidden TB infections by attacking a critical process the bacteria use to survive in the hostile environment of the lungs.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
The Do’s and Don’ts of SPR Experiments
Surface Plasmon Resonance (SPR) is a technique that is becoming more widely used, particularly by anyone who wants to obtain accurate on (association) and off (dissociation) rates for biomolecular binding.
Long-Sought Protein Sensor for the ‘Sixth Sense’ Discovered
In a study led by scientists from The Scripps Research Institute (TSRI)the sensor protein for propioception has been identified.
New Anti-Malarial Drug Screening Model
University of South Florida researchers demonstrate novel chemogenomic profiling to identify drug targets for the most lethal strain of malaria.


Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos