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Scientific News
Direct Drug Screening Of Biopsies Could Overcome Resistance
Combining genetic with pharmacologic screening of tumors may enable truly individualized treatment regimens.
Almac Announces Launch of CLIA Validated Next Generation Sequencing Assay
P53 considered important biomarker for cancer drug discovery.
Next-Gen Melanoma Drug Excels in Lab Tests
Anti-cancer activity was reported in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733.
Blood Test Could Reduce Antibiotic Use
A new blood biomarker test that indicates whether bacteria is the cause of a patient’s lung infection is now being studied at UPMC Presbyterian.
New Targets and Test to Develop Treatments for Memory Disorders
The study focuses on kinesin, a molecular motor protein that plays a role in the transport of other proteins throughout a cell.
Drugging the Undruggable
Discovery opens up possibility of slowing cancer spread.
Classification of Gene Mutations in Neuroblastoma
Penn Medicine and CHOP experts define riskier mutations in neuroblastoma, setting stage for clinical trial.
Microscopic “Walkers” Find Their Way Across Cell Surfaces
Technology could provide a way to deliver probes or drugs to cell structures without outside guidance.
Study Investigates Inherent Contamination in Deep Well Microplates
Study gives data on microplates from numerous manufacturers based in Europe, USA and China.
Culture System Replicates Course Of Alzheimer’s Disease
Three-dimensional system should significantly reduce time and costs of drug development.

Multi-analyte Procedures for Target Screening and Quantification of Drugs in Blood using LC-MS/MS: Possibilities and Limitations
Hans Maurer, Saarland University, speaking at European Lab Automation 2012.

Sample Management and HTS: Convergent Platforms and Universal Solutions to Simplify the Integration Challenge
Chris Walsh, Brooks Life Science Systems, speaking at European Lab Automation 2012

Dynamic Cell Culture for Drug Discovery: Stretching Mechanotransduction from the Lung to the Lab
Dr. Sanjit Nirmalanandhan, University of Kansas Medical Center, speaking at Cell Culture 2012.

ESPRIT: High Throughput Screening for Soluble Expression Constructs of Difficult-to-express Proteins
Darren Hart, European Molecular Biology Laboratory, speaking at European Lab Automation 2012

Fragment Based de novo Ligand Design: A Valuable Optimisation Tool in Fragment Based Lead Discovery
Peter Johnson, University of Leeds, speaking at Discovery Chemistry Congress 2012.

Fragment-Based Drug Discovery - Getting in Shape
Doris Hafenbradl, Biofocus, speaking at Discovery Chemistry Congress 2012.

The Versatility of Fragment Screening Approaches and the Application of Fragment Binding Information in Durg Discovery
Stefan Geschwindner, AstraZeneca, speaking at Discovery Chemistry Congress 2012.

Challenges of an Open Access Screening Platform in Academia
Edgar Specker, Leibniz Institute of Molecular Pharmacology, speaking at European Lab Automation 2012

Defence and Adaptation in Drug-Mediated Liver Toxicity
Christopher Goldring, University of Liverpool, speaking at ADME & Predictive Toxicology Europe 2012

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