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Application Notes

 
Direct Visualisation, Sizing and Counting of Aggregation in Proteins
Application Note

NanoSight Limited

Characterising the state of aggregation in proteins is of paramount importance when trying to understand biopharmaceutical product stability and efficacy. Product quality, both in terms of biological activity and immunogenicity can be highly influenced by the state of protein aggregation.

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Automated High Throughput Functional Cell-based Bioassays for EGFR Blocking Antibodies
Application Note

This study describes a novel, target-specific, cell-based assay platform that can be used to detect and differentiate potential inhibitors of Epidermal Growth Factor receptors.

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Applications of rapid immunoassays (FAST ILA) in cell culture/fermentation and process development using the Threshold System
Application Note

Molecular Devices

Accurate measurement of the concentration of a biological product is important in bioreactor/fermenter monitoring, downstream processing and final product quality control. Currently, electrophoretic, chromatographic and immunochemical methods are the most commonly used. These three methods are currently used in combination to provide the desired sample information.

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Optimizing the Labeling of Proteins
Application Note

Molecular Devices

The Threshold® Immuno-Ligand Assay (ILA) adapts reagents used in ELISA, RIA or radioreceptor assays for the Threshold System by covalently attaching biotin or fluorescein labels to the binding proteins and/or ligands. To simplify labeling and purification of proteins, Molecular Devices has formulated biotin and fluorescein as N-hydroxysuccinimide esters.

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The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
Application Note

BMG Labtech

ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.

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Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
Application Note

BMG Labtech

During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.

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Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay
Application Note

Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.

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LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader
Application Note

LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.

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Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Application Note

The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.

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Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Application Note

The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.

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