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Webcasts
Webinar: Bestimmung von Dioxinen und dioxinähnlichen PCBs mittels GC/QQQWebinar: Bestimmung von Dioxinen und dioxinähnlichen PCBs mittels GC/QQQ
Screen and Confirm Food Residues Confidently. Webinar Event for 'Food' Solutions on September 18th 2014, 15:00 PM CET.
Insights from Metabolomics in Compartmented CellsInsights from Metabolomics in Compartmented Cells
Ralf Takors, University of Stuttgart, speaking at Advances in Cellular Assays & Cell Culture 2014

Market Reports
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Gene Expression Analysis Market by Technology, Consumables, Services & Applications - Global Forecast to 2018
MarketsandMarkets

Over the years, the gene expression analysis market, comprising of instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of gene expression applications.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
High Throughput Screening (HTS) Market by Technology, Applications, and End Users - Forecast to 2018
MarketsandMarkets

Technological advancements and flourishing outsourcing industry likely to propel the growth of the global high throughput screening market. In this report, the global high throughput screening market has been segmented on the basis of technology, products, applications, end users, and geography.
Chromatography Resin Market by Application, Techniques & Type - Trends & Forecast to 2018
MarketsandMarkets

The chromatography resin market is expected to grow at a decent pace during the coming decade driven by its increasing application in monoclonal antibody production and food analytics.
Chromatography Accessories and Consumables Market by Types, Technology & End-users - Trends & Global Forecasts to 2018
MarketsandMarkets

The chromatography accessories and consumables market demands significant investments in R&D in order to constantly come up with new and innovative products and technologies.
Food Diagnostics Systems Market, Consumables Market & By Geography - Global Trends & Forecast To 2018
MarketsandMarkets

The food diagnostics market size is projected to increase with rising concerns over food quality and safety, and the implementation of stringent regulations on food safety and foodborne illness prevention.
Chromatography Reagents Market By Type, Bed Shape, Mobile Phase, Separation Mechanism & End User - Global Forecasts to 2018
MarketsandMarkets

The market is expected to witness a high growth due to high demand of chromatography reagents in the growing pharmaceutical market.
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Scientific News
Single Animal to Human Transmission Event Responsible for 2014 Ebola Outbreak
NIH-funded scientist uses latest genomic technology to make discovery.
Watching Molecules ‘Dance’ in Real Time
Trapping light at the nanoscale enables real-time monitoring of individual molecules bending and flexing may aid in our understanding of how changes within a cell can lead to diseases such as cancer.
Repressing the Repressors May Drive Tissue-Specific Cancers
Stowers scientists establish Drosophila and mammalian models to study mutations found in pediatric brain tumors.
Genetic Basis for Rabbit Domestication Revealed
Research presents key findings in the DNA make-up of the common mammal’s brain and nervous system, which determines how wild rabbits were genetically transformed to domestic rabbits.
Fighting Prostate Cancer with a Tomato-Rich Diet
New research suggests that men who eat over 10 portions of tomatoes a week have an 18% lower risk of developing prostate cancer.
Scientists Looking Across Human, Fly and Worm Genomes Find Shared Biology
Studies reveal powerful commonalities in biological activity and regulation among species.
Genetics Used to Improve Plants for Bioenergy
An upcoming genetics investigation into the symbiotic association between soil fungi and feedstock plants for bioenergy production could lead to more efficient uptake of nutrients, which would help limit the need for expensive and polluting fertilizers.
NIH to Launch Human Safety Study of Ebola Vaccine Candidate
Trial is First in Series of Accelerated Safety Studies of Ebola Vaccines.
Gut Bacteria that Protect Against Food Allergies Identified
Common gut bacteria prevent sensitization to allergens in a mouse model for peanut allergy, paving the way for probiotic therapies to treat food allergies.
Detecting and Identifying Candida Species in Blood Samples of Critically Ill Paediatric Patients
The study aimed to develop a multiplex nested PCR method to detect and identify seven Candida species in peripheral blood samples of critically ill paediatric patients.
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Business News
Recipharm to Acquire Corvette for SEK 1.1 Billion
Corvette will contribute to Company’s Intellectual Property backed manufacturing business.
New NIH Research Awards to Address Multiple Chronic Conditions
Grants funded through the National Institutes of Health's HCS Research Collaboratory.
Dezima Reports Positive Results in its Phase 2b TULIP Trial
Combines outstanding efficacy and safety profile with favourable pharmacokinetics.
Cellular Dynamics Awarded U.S. Patent
Patent strengthens CDI’s position as leading manufacturer of human cells for research and clinical applications.
AB SCIEX and Dalton Collaborate to Advance ADC Analysis
Collaboration supports movement to develop targeted anti-body based therapies.
Roche and InterMune Reach Definitive Merger Agreement
Roche to acquire InterMune for US$ 74.00 per share.
Merck Millipore Expands Biomanufacturing Sciences and Training Center in Japan
Facility expansion and relocation of existing operations from Yokohama, Kanagawa Prefecture to Tokyo.
Donald Johns Joins Biogen Idec to Lead ALS Innovation Hub
Renowned neurologist to focus on accelerating the Company’s discovery and development of ALS therapies.
Robert Hureau Joins PPD
Company appoints Robert Hureau as executive vice president and chief financial officer.
Novozymes, Monsanto Showcase Innovations Expected to Increase Farm Sustainability
Companies’ BioAg Alliance working to develop innovations for agriculture to boost productivity.
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Events
BIT
29 Aug 2014
BIT's 4thAnnual World Congress ...
SLAS Short Courses
01 Sep 2014
SLAS Short Courses ...
ELRIG - Drug Discovery 2014
02 Sep 2014
ELRIG - Drug Discovery 2014 ...
DNA polymerases: biology, dise
31 Aug 2014
DNA polymerases: biology, dise ...

ePosters
PRESEPSIN, A SOLUBLE CD14-SUBTYPE, A POSSIBLE NEW BIOMARKER INCREASES IN SEPTIC PATIENTS’ PLASMA FROM PEDIATRIC DEPARTMENT.
1) Department of Laboratory Medicine, 2) Department of Pediatrics, Showa University Northern Yokohama Hospital

Increased plasma concentration of soluble CD14-subtype (presepsin) was observed in pediatric patients with bacteremia. Presepsin could be a possible biomarker of sepsis in pediatric patients, however, their reference interval in children could be lower than that of adults. More studies with larger number of samples are required to confirm the result.

DETERMINATION OF HOMOCYSTEINE THIOLACTONE IN URINE BY FIELD AMPLIFIED SAMPLE INJECTION AND SWEEPING MEKC METHOD WITH UV DETECTION
Department of Environmental Chemistry, Faculty of Chemistry, University of Lodz, 163 Pomorska Str., 90-236 Lodz, Poland

* The procedure does not overload the capillary and has positive effect on the increase in peak hight,
* The method allows about 70-fold increase in method sensitivity,
* The limits of detection and quantification are 0.1 nmol and 0.09 nmol of Hcy-thiolactone in 1 mL of urine, respectively,
* Presented assay can be used for the determination of Hcy-thiolactone in biological samples.
CAPILLARY ELECTROPHORESIS OF APIGENIN
Department of Environmental Chemistry, Faculty of Chemistry, University of Lodz, 163 Pomorska Str., 90-236 Lodz, Poland

* Application of an appropriate mode of extraction allowed to use on-line stacking method for the determination of apigenin in plant extracts,
* The low limit of detection was 5 nmol in 1 mL of plant extract,
* Presented procedure allows approximately 20-fold increase of sensitivity,
* Elaborated assay can be useful for the determination of apigenin in biological samples.
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF LIPOIC ACID IN THE FORM OF 2-S-PYRIDINIUM DERIVATIVE
(1) University of Lódz, Faculty of Chemistry, Department of Environmental Chemistry, 163 Pomorska Str., 90-236 Lódz, Poland (2) Jagiellonian University, Medical College, Krakow, Poland (3) Fressenius

* The method can be used for routine clinical monitoring of LA in human plasma and urine.
* The method was validated for urine and plasma samples.
* The imprecision, expressed as relative standard deviation value, were within range 0.8-7.7% and 0.9-6.2% for plasma and urine samples, respectively.
* The analytical recovery were from 97.3 to 117.0% for plasma and from 96.5% to 111.5% for urine samples.
APPLICATION OF LIQUID CHROMATOGRAPHY WITH UV DETECTION FOR DETERMINATION OF PLANT GROWTH REGULATOR IN COMMON PLANT FERTILIZERS
Department of Environmental Chemistry, Faculty of Chemistry, University of Lodz, 163 Pomorska Str., 90-236 Lodz, Poland

1. The methodology allows facile and accurate determination of IBA in common plant fertilizer samples.
2. The analytical figures of linearity, precision and recovery shown during the method validation procedure are well within the criteria for biological sample analysis.
3. In temperature -18, 4 and 25 °C the analyte stays stable for 6 h.
4. The assay should help in control of phytohormones concentration in plants and fertilizers.
INTERACTION BETWEEN WHEY PROTEIN NANOPARTICLES AND FATTY ACIDS
*Food Science Department; Faculity of Agriculture; Ain Shams University; Cairo; Egypt **Dairy Science &Technology Department, National Research Center, Egypt. ***Interdisciplinary Nanoscience Center,

Nanocomplexes can be formed from WPI with good cytotoxic effect to tumer cells using cis-vaccenic and linolenic fatty acids comparable to oleic acid. It was a new interesting observation being that the nanocomplexes formed of WPI with fatty acids has a comparable cytotoxcisty to that of a-LA and ß-lg and can be used in tumor therapy.
A Rapid and Effective Tool for Monitoring Monoclonal Antibody Production
MedMira Laboratories Inc

Monoclonal antibodies (Mab) are used in a variety of fields from diagnostics to therapeutics. Manufacturers of in vitro diagnostics (IVD) commonly use third-party suppliers to meet their needs for specified monoclonal antibodies.
A Novel Approach Toward Microfluidic Drug Metabolite Synthesis – Electrosynthetic Methodology Simulating Cytochrome (CYP450) Oxidation
Sanford Burnham Medical Research Institute at Lake Nona and Syrris Ltd

A novel microfluidic technology and electrochemical synthesis method is demonstrated for the efficient generation of known drug metabolites. These metabolites are typically generated on first pass hepatic oxidation in vivo. The FLUX Module, a new microfluidic electrochemical cell manufactured by Syrris Ltd., has been employed to generate the metabolites of five commercial drugs: Tolbutamide, Chlorpromazine, Diclofenac, Primidone and Albendazole.
MS Data Processing With Full Flexibility Of Universal Processing Software
Thermo Fisher Scientific

Liquid Chromatography (LC) in combination with triple quadrupole Mass Spectrometry (MS) is more and more a common analysis technique in routine laboratories. Especially when using MS/MS selected reaction monitoring (SRM) for a large number of components data handling can be a bottle neck. This poster will show MS data processing of pesticides in water samples using an already established chromatography data system which is now also capable of processing large quantities of MS data.
Analysis of Dithiocarbamate Pesticides by GC-MS
Thermo Fisher Scientific

Analysis of dithiocarbamate pesticides (DTCs) using an optimized GC-MS method is described. DTCs are not stable and cannot be extracted or analyzed directly. The purpose of this work was develop a reliable method for identification and quantification of residues.
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Application Notes
Differentiation and characterization of subvisible particulates in therapeutic protein products
Malvern Instruments Limited

The formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due to the potential for increased immunogenicity.
An Introduction to Proteins in 30 minutes
Malvern Instruments Limited

In the biotechnology industry, the majority of research is directed towards characterizing the structure and function of proteins. New methods are continually being developed to accomplish this.
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
Simple sample preparation for the determination of vitamin D in serum by LC-MSMS
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the AC Extraction Plate and the Tecan Freedom EVO® for the quantification by LC-MS/MS
Tecan Group Ltd.

There is an increasing demand for the determination of Vitamin D status which is based on the quantification of the two metabolites 25-OH-Vitamin D3/D2. Numerous laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) because of its specificity combined with high sensitivity. Moreover LC-MS/MS offers the potential for multianalyte determination which is required for Vitamin D status determination.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Automated sample preparation for the determination of testosterone in serum by LC-MSMS
Tecan Group Ltd.

For accurate, reproducible quantification of testosterone, a growing number of laboratories are shifting from immunoassay to liquid chromatography coupled with tandem mass spectrometry. This application note describes the preparation of serum samples for subsequent LC-MS analysis of testosterone, focusing on a streamlined workflow suitable for automation.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
Tag-lite® two-cell assay: a valuable tool for protein drug discovery
Tecan Group Ltd.

Antibodies are central mediators of the immune system, IgG being the most dominant. Binding of IgG/antigen complexes to membrane-bound Fc? receptors triggers a cellular immune response. Alterations in the Fc portion of the antibody by introducing mutations can lead to complete abolition of Fc? receptor binding. This describes the development of a cellbased TR-FRET assay to determine the simultaneous binding of an antibody to its antigen and huFc?RIIIa present on different cells.
Transcreener® ADP2 TR-FRET Red Assay
Tecan Group Ltd.

Adenosine diphosphate (ADP) is an important mediator of cellular metabolism that is essential for maintaining energy levels. The Transcreener ADP2 TR-FRET Red Assay is intended for the detection of ADP production by any kinase or ATPase, and has been developed specifically for high throughput screening applications.
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