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Webcasts
Solutions Beyond Water - Successfully pipetting problematic liquidsSolutions Beyond Water - Successfully pipetting problematic liquids
Join us to learn how to best handle problematic liquids.
Expanding Possibilities for Compound Library Generation in Flow with Immobilized and Exchangeable ReagentsExpanding Possibilities for Compound Library Generation in Flow with Immobilized and Exchangeable Reagents
Noah Tu, Senior Scientist, Abbvie Inc, Speaking at Flow Chemistry Congress.

Market Reports
High Throughput Assay Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on high throughput flow cytometry (HT flow) screening carried out in December 2014.
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
Epigenetic Proteins & Reagents Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on epigenetic proteins and reagents carried out in March 2015.
3D Spheroid Culture Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on three dimensional (3D) spheroid culture carried out in May 2015.
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
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Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
COPD Linked to Increased Bacterial Invasion
Persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
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Business News
Featured Article
Helsinki Chemicals Forum Zeros in on The Circular Economy
Chemicals Management and Sustainable Chemistry Highlighted During Upcoming Conference in May

Agilent Presents Thought Leader Award to Renowned Medicinal Scientist
Company has announced that Dr. Shilin Chen has received an Agilent Thought Leader Award in support of his groundbreaking herbal genomics research using multi-omics techniques.
Fluxion Biosciences, UT Health Collaborate
Company has announced collaboration with UT Health to develop novel liquid biopsy approaches to improve the ability to diagnose, monitor, and treat cancer patients.
Macrogen, National Cancer Center Korea Sign Agreement
Company has signed a business agreement with National Cancer Center Korea for joint research into genome information-based precision medicine with cancer patients.
Zika Test from Quest Diagnostics Authorized by the FDA
Company has announced that it has received a U.S. FDA emergency use authorization for the Zika Virus RT-PCR test.
Aptuit Announces Acquisition of Exquiron Biotech AG
Company has announced that it has acquired Exquiron Biotech AG to meet customer demand for fully integrated outsourced discovery services.
Recursion Announce Agreement With Sanofi Genzyme
Company has announced a research agreement with Sanofi to deploy its drug repurposing platform to identify new uses for Sanofi’s clinical stage molecules across dozens of genetic diseases.
CytomX, AbbVie Announce Collaboration
Company has announced collaboration with AbbVie to co-develop and co-commercialize Probody™ Drug Conjugates against CD71.
IBC Generium Selects Goodwin Biotechnology
Company has selected Goodwin Biotechnology to optimize the process, scale-up, and manufacture an IgG-based bispecific antibody for phase I clinical trials.
Liquid Biotech USA, MolecularMatch Partner
Company has announced partnership with Liquid Biotech to expedite cancer detection and treatment.
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Events
Medicare Conference 2016
02 May 2016
Medicare Conference 2016 ...
eSource Data in Clinical Inves
02 May 2016
eSource Data in Clinical Inves ...
2nd European Clinical Trials I
03 May 2016
2nd European Clinical Trials I ...
Italian ePharma Day
05 May 2016
Italian ePharma Day ...

ePosters
Analyzing Cell Viability in 3D Tissue Models with the ViaLight™ Plus BioAssay
1Lonza Cologne GmbH, Cologne, Germany; 2Lonza Walkersville Inc., Walkersville, MD, USA; 3Lonza Rockland Inc., Rockland, ME, USA

This poster explains how to measure cell viability easily in 3D cell cultures using the ViaLight™ Plus BioAssay.
Cell Culture and Cell Analysis using the Real Architecture for 3D Tissue (RAFT™) Culture System
1TAP Biosystems, Royston, UK;2Lonza Cologne GmbH, Cologne, Germany; 3Lonza Walkersville Inc., Walkersville, MD, USA

This poster explains how standard analysis techniques, like fluorescence microscopy, can be applied easily to RAFT™ 3D Cell Cultures.
Comparison of Normal and Asthmatic Bronchial Epithelial Cells and Smooth Muscle Cells in Monolayer and RAFT™ 3D Cell Culture System
1Lonza Walkersville Inc. Walkersville MD USA, 2Lonza Cologne GmbH, Cologne, Germany

The RAFT™ 3D cell culture system provides a valuable tool to investigate different cell types singularly or in co-cultures in an in-vivo like collagen based microenvironment.
Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System
1Lonza India Pvt Ltd, Hyderabad, India; 2Lonza Cologne GmbH, Cologne, Germany; 3Lonza Walkersville, Inc., Walkersville, MD, U.S.A.

In the current study we have used siRNA targeting VEGFR2 as an example to study knockdown of VEGFR2 and subsequent inhibition of tube formation by HUVECs on Growth Factor Reduced Matrigel™ in a 96-well plate format. The same strategy can be used for screening and validating siRNA based inhibitors of the angiogenic process in vitro and thus could be of utility in anti-cancer screening strategies.
Pharmacological Responses in Cultured Human iPSC-Derived Cortical Neurons Using Multi-Electrode Array
(1) Department of Electronics and Intelligent Systems, Tohoku Institute of Technology, Sendai, Miyagi, Japan; (2) Japan Society for the Promotion of Science, Tokyo, Japan; (3) Axol Bioscience Ltd., Ca

The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a potentially powerful in vitro model for evaluating disease mechanisms and drug responses. However, the culture time required for the full functional maturation of individual neurons and networks is uncertain. We investigated the development of spontaneous electrophysiological activity and pharmacological responses for over 1 year in culture using multi-electrode arrays (MEAs).
Clinical Applications of “Liquid biopsy” in the Colorectal Cancer Treatmen
Saitama Medical Center, Jichi Medical University, Saitama. Japan

Liquid biopsy provides a circulating biomarker not only for treatment response but decision making of a sequential strategy.
Instrumental Investigations: A Laboratory Manual of Forensic Analytical Chemistry
Oberlin College

A laboratory manual for undergraduate analytical and forensic chemistry courses
Targeting Acute Pancreatitis by Small Molecule Inhibitors of Cyclophilin D
The University of Liverpool

Cyclophilin D (CypD) promotes opening of the mitochondrial permeability transition pore, a major contributor to acute pancreatitis. We are developing small molecule inhibitors of CypD as a possible treatment for AP and other conditions where the MPTP plays a role.
The Pathogen Box: A Catalyst for Neglected Disease Drug Discovery
Medicines for Malaria Venture, Switzerland

Modelled after the Malaria Box, the Pathogen Box contains ~400 diverse drug-like molecules active against neglected diseases of interest such as Chagas disease, cryptosporidiosis, hookworm, sleeping sickness, leishmaniasis, lymphatic filariasis, malaria, onchocerciasis, schistosomiasis, trichuriasis, tuberculosis.
Rapid electrochemical impedance spectroscopy for protein detection in Lab-on-a-Chip devices
(a) Thomas Johann Seebeck Department of Electronics, Tallinn University of Technology, Tallinn, Estonia; (b) Protobios OÜ, Tallinn, Estonia

We present results in rapid solution impedance spectroscopy to detect protein interactions (antibody-antigen) in human serum. Two different serum-antibody mixtures are measured in cuvettes, interfaced with screen-printed electrodes to determine whether the experimental setup can detect differences in composition.
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Application Notes
Rapid point of use DNAble® assay for citrus greening disease (Candidatus Liberibacter spp.) using the Douglas Scientific® AmpliFire®
Douglas Scientific

In this experiment, a crude insect preparation and a DNAble assay were used to demonstrate that the AmpliFire instrument accurately detects the presence of HLB-causing bacteria consistent with a real-time PCR system. The AmpliFire offers greater portability than real-time PCR instrumentation, and is a powerful tool for point of use applications such as management of citrus greening disease.
Multipette®/ Repeater® M4 Allows for Fast, Precise and Sterile Liquid Transfer in Cell Culture
Eppendorf AG

This application note demonstrates the huge advantages offered by Multipette M4 in terms of accuracy and precision needed for many cell culture applications.
Characterization of Protein-Protein Interactions using Triple Detection Size Exclusion Chromatography (SEC-TD)
Malvern Instruments Limited

In this application note, triple detection size exclusion chromatography (SEC-TD) is used to understand the ability of proteins to form ordered, structured complexes. The controlling mechanism behind these protein complexes is fundamental to our knowledge of protein signaling pathways and the physiological responses they control.
Microbial Detection and Quantification Using the IntelliQube® from Douglas Scientific®
Douglas Scientific

Nucleic Acid Testing (NAT) is a powerful tool for the quantification of microorganisms and are used in many fields. In this study commercially available microbial NAT kits were successfully miniaturized from 20 µL to 1.6 µL reaction volumes using the IntelliQube. The IntelliQube delivers efficient and economical high throughput sample processing for microbial qPCR applications.
Evaluation of a New Accurate, Automated and Cost-effective Approach for the Analysis of Pharmacologically Important Copy Number Variation
Douglas Scientific

The IntelliQube® from Douglas Scientific® is designed to address the need for accurate and reliable results for studies such as CNV determination.
Formation of Monodispersed Microbubbles
Dolomite

This application note describes how the Mitos P-Pump can be used in combination with the Droplet Junction Chip to produce monodispersed gas bubbles.
Gas Bubble Generation in Water using Dolomite's Small Droplet System
Dolomite

This application note describes a hydrodynamic flow-focussing based system for the monodisperse formation of nitrogen bubbles using the Small Quartz Droplet Chip based Small Droplet System.
Quantifying µ-Scale Mixing Time of Sodium Hydroxide and Phenolphthalein Using Dolomite's Micromixer System
Dolomite

This application note evaluates mixing using a rapid chemical reaction causing a colour change as the indicator of mixing.
Introduction to Mixing and Droplet Production in Microfluidics using Dolomite's Educational Microfluidic System
Dolomite

This application note introduces researchers to fundamental fluid operations in microfluidics using Dolomite's Educational Microfluidic System.
Characterisation of Droplet Junction Chip with Hexadecane and Water
Dolomite

This application note describes how Dolomite's Droplet Junction Chip can be used to generate water droplets in a hexadecane oil carrier stream. By controlling the pressure of the oil and water input reservoir, different flow regimes and droplet sizes were observed.
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