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Featured ProductVutara 352 World’s Only Quantitative Super-Resolution Microscope — Fast and Meaningful 3D Imaging for Live Cells company logo
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Webcasts
Innovative Benign-by-design Flow Chemistry Protocols: From Nanomaterials Synthesis to Biomass/Waste Valorization Innovative Benign-by-design Flow Chemistry Protocols: From Nanomaterials Synthesis to Biomass/Waste Valorization
In this webinar Professor Rafael Luque will present recent developments in benign-by-design continuous flow chemical protocols for various topics ranging from nanomaterials synthesis (supported nanoparticles) to biomass and waste valorisation.
Lab-on-Chip Platform Technologies for Point-of-Care Testing and Cell CulturingLab-on-Chip Platform Technologies for Point-of-Care Testing and Cell Culturing
This presentation focuses on recent advances in platform technologies developed at Micronit for applications within point-of-care diagnostics and cell culturing. A few examples developed within research projects are presented to illustrate the applicability of the developed technologies.

Market Reports
High Throughput Assay Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on high throughput flow cytometry (HT flow) screening carried out in December 2014.
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
Epigenetic Proteins & Reagents Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on epigenetic proteins and reagents carried out in March 2015.
3D Spheroid Culture Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on three dimensional (3D) spheroid culture carried out in May 2015.
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
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Scientific News
Retractable Protein Nanoneedles
The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.
Leukemia’s Surroundings Key to its Growth
Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous.
Common Cell Transformed into Master Heart Cell
By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.
‘Smelling’ Prostate Cancer
A research team from the University of Liverpool and the University of the West of England (UWE Bristol) has reached an important milestone towards creating a urine diagnostic test for prostate cancer that could mean that invasive diagnostic procedures that men currently undergo eventually become a thing of the past.
Genetic Mutation that Prevents Diabetes Complications
The most significant complications of diabetes include diabetic retinal disease, or retinopathy, and diabetic kidney disease, or nephropathy. Both involve damaged capillaries.
A Crystal Clear View of Biomolecules
Fundamental discovery triggers paradigm shift in crystallography.
Could the Food we Eat Affect Our Genes?
Almost all of our genes may be influenced by the food we eat, according to new research.
NIH Seeks Research Applications to Study Zika in Pregnancy, Developing Fetus
Institute has announced that the new effort seeks to understand virus effect on reproduction and child development.
Iron in the Blood Could Cause Cell Damage
Concentrations of iron similar to those delivered through standard treatments can trigger DNA damage within 10 minutes, when given to cells in the laboratory.
Criminal Justice Alcohol Program Linked to Decreased Mortality
Institute has announced that in the criminal justice alcohol program deaths dropped by 4.2 percent over six years.
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Business News
Featured Article
Multi-Mode Microplate Reader Trends
In this article we explore end-user opinion of some the new features available on MM plate readers and their potential influence on purchasing decision for a new MM plate reader.

Immunovia, Lund University Collaborate
Immunovia initiates a new program to focus on the development, validation and commercialization of antibody array based tests for differential diagnostics and for prediction/monitoring of flares for SLE also known as “lupus”.
Circulogene, UAB Collaborate
Circulogene Theranostics, the only biotechnology company able to enrich circulating cell-free DNA (cfDNA) from a single blood drop for patient-specific monitoring of cancer, has announced a research agreement with the University of Alabama Birmingham (UAB) Comprehensive Cancer Center.
GRAM Announces Successful FDA Inspection
Company has announced to be in compliance with Current Good Manufacturing Practices and passed the Pre-Approval Inspection with no Form 483 observations issued.
Pharmaron Acquires Quotient Bioresearch
Company has announced that it has acquired Quotient Bioresearch to enhance service offerings and increase presence in global markets.
Cirrus to Launch Clinical Trial Manufacturing
Company has announced that it is ready to launch its services for manufacturing cGMP materials for clinical trials.
Velesco Pharma Opens New Analytical Testing Laboratory
Company has announced that it has opened new CGMP-compliant analytical testing laboratory for development of vaccines and biologics with improved stability and preserved potency.
HUYA Grants an Exclusive License to Eisai
Eisai to commercialize HUYA’s Product HBI-8000 in Japan and Other Asian Countries.
Agilent Technologies and 10x Genomics Announce Collaboration
Company has announced collaboration to develop a premium exome that provides a streamlined workflow for 10x Genomics'Chromium platform.
Qualicaps® Acquires Genix Industria Farmaceutica Ltda
Company has announced that acquisition allows the company to effectively expand its global presence from operating sites in Japan, Spain, Romania, Canada and the USA, to include Brazil.
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Events
Advances and Progress in Drug
15 Feb 2016
Advances and Progress in Drug ...
RNAi Therapeutics
15 Feb 2016
RNAi Therapeutics ...
7th International Conference o
15 Feb 2016
7th International Conference o ...
4th Biotechnology World Congre
15 Feb 2016
4th Biotechnology World Congre ...

ePosters
Design considerations for highly specific and efficient synthetic crRNA molecules
GE Healthcare Dharmacon, Inc.

An overview of our rational design algorithm for picking highly functional crRNA sequences in combination with comprehensive specificity analysis.
A New Dual Luciferase Assay Using NanoLuc® Enables a Second Generation Coincidence Reporter System to Reduce False Hits in HTS Poster
Promega Corporation

Luciferase-based reporter-gene assays remain a cornerstone of high-throughput screening of compounds because of their high sensitivity and dynamic range. However, a substantial number of non-relevant hits can be generated due to direct interaction of compounds with the luciferase reporter.
A Novel Bioluminescent HTS Method for Rapid NAD(P)/NAD(P)H Detection Poster
Promega Corporation

Nicotinamide adenine dinucleotides (NAD+, NADH, NADP+ and NADPH) are fundamental co-factors of cellular energy metabolism. These dinucleotides are essential for macromolecule biosynthesis and the maintenance of the cellular redox potential. Our new rapid, easy-to-use assays for measuring dinucleotides are convenient tool for investigating their role in these processes.
A Simple Plate Based Assay Using pH Sensor Dye to Screen for Internalizing Antibody
Promega Corporation

Receptor mediated internalization is a key mechanism of action (MOA) for antibody drug conjugates (ADCs). However, current methods of studying antibody internalization have several limitations including: 1) A multistep process not suitable for screening; 2) Low signal-to-background ratios; 3) Not suitable for kinetic measurements. We have developed a method that mitigates problems associated with traditional internalization assays.
An IgG Cleaving Protease from S equi with Improved Activity Against Mouse IgGs
Promega Corporation

Here we have expressed and purified a modified recombinant IdeZ, and show that it has significantly improved activity against mouse IgG2a and IgG3 subclasses when compared to IdeS. We also demonstrate the use of IdeZ in LC-MS workflows for human and mouse IgG characterization.
Better Cell-Based Assays for Anti-CTLA-4, Anti-PD-1/PD-L1, and Bispecific Immunotherapy Drug Studies
Promega Corporation

Here we report the development of a panel of robust reporter assays to measure the potencies for biologics in immunotherapy. These assays reflect mode of action and can serve as valuable tools in immunotherapy drug development and discovery.
CellTiter-Glo® 2.0: A Novel Luminescent Cell Viability Assay with Greatly Enhanced Storage Stability
Promega Corporation

Here we report on the attributes of a novel ATP detection reagent for cell viability with all of the assay performance of the previous CellTiter-Glo® Reagent, but now with markedly enhanced stability as a single component in a liquid format. These new features provide for much greater ease-of-use in that storage of the reagent at 4°C eliminates the requirement for reagent thawing and minimizes temperature equilibration time.
Design and Validation of Bioluminescent Assays for 3D Cell Culture Models Poster
Promega Corporation

Cells cultured in 3D model systems often acquire relatively large in vivo-like structures compared to the thickness of a 2D monolayer of cells grown on standard plastic plates.
Development of a Robust Reporter-based T cell Activation Assay for Therapeutic Biologics in Immunotherapy
Promega Corporation

Jurkat T-cells stably expressing luciferase reporter driven by IL2 promoter or NFAT-RE, are used as effector cells. Tumor cell lines endogenously expressing cancer antigen are used as antigen presenting cells (APC). By co-cultivating the two cell lines in the presence of CD3 bispecific antibody, TCR/CD3 is activated in Jurkat effector cells. Luciferase activity is up regulated through IL-2 promoter or NFAT-RE activation.
iPSC-Derived Cardiomyocytes and Luciferase Reporters: A Robust Reporting Platform for Monitoring Cardioprotection and Pathway Biology in Endogenous Human Tissue Cells
Promega Corporation

Pathophysiological conditions, medical interventions, and off-target toxicities can all result in cellular oxidative stress. In cardiac myocytes, prolonged and/or excessive oxidative stress can lead to cardiotoxicity: a primary cause of developmental delays, black-box warnings, and post-launch withdrawal of pharmaceuticals.
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Application Notes
Muliplex SNP Genotyping of Field Corn Crude Samples with Probe-Based Assays using the IntelliQube® from Douglas Scientific®
Douglas Scientific

This study evaluated multiplex genotyping on the IntelliQube, a PCR instrument optimized for 1.6 µL reaction volumes in Array Tape®. It demonstrates the feasibility of achieving two SNP genotyping results in a single reaction well. IntelliQube provides cost savings through miniaturized PCR reaction volumes, shorter thermal cycling times, and multiplex reactions without compromising data quality.
Rapid point of use Grouper Chek™ assay using the Douglas Scientific® AmpliFire® detects seafood fraud
Douglas Scientific

The AmpliFire by Douglas Scientific along with GrouperChek isothermal amplification chemistry from PureMolecular, LLC provide a simple and portable tool to perform genetic analysis at the point of use. This paper demonstrates the ability of the AmpliFire combined with the GrouperChek assay to differentiate the highly prized grouper from tilapia, a common illegal substitute.
ENRICHMENT AND PURIFICATION OF CD3+ T-CELLS FROM HUMAN UMBILICAL CORD BLOOD
Quad Technologies

Quad Technologies’ has partnered with the University of Massachusetts Medical School (Worcester, MA, USA) to evaluate the performance of the MagCloudz™ Streptavidin cell separation kit.
Using the Morphologi G3 for evaluating ceramic granules produced by a spray drying process
Malvern Instruments Limited

From the humble cereal bowl to the intricate electronic components in your mobile phone and even body armour, ceramics are found in a diverse range of industries and applications.
Application of microcalorimetry in drug discovery at Exelixis
Malvern Instruments Limited

Understanding the molecular details of drug-target protein interactions is a critical component of the drug discovery process in the modern pharmaceutical industry.
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
Malvern Instruments Limited

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.
Monitoring structure rebuild (thixotropy) following extrusion from a bottle, tube or spray head
Malvern Instruments Limited

A three-step strain/shear rate test was performed on a toothpaste and hair gel to evaluate the rate and extent of elasticity recovery following extrusion from a tube.
Analysis of Demicellization Data from Isothermal Titration Calorimetry
Malvern Instruments Limited


Optimizing Fluid Rheology for Enhanced Oil Recovery Applications: A Case Study
Malvern Instruments Limited

In this case study we present elements of the work carried out by Rafael Hincapie as part of his PhD project at TU Clausthal to better understand how viscoelastic properties of EOR polymers influence oil recovery performance.
Characterization of IgG Monomers & Their Aggregates
Malvern Instruments Limited

A comparison between column calibration & multi-detection SEC.
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