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World of Technology & Science 2014...
Finding Needles in a Haystack with Q-PCR...m-VROCi - microfluidic rheometer for ind...  Public Knowledge of Stem Cells in the ...

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Webcasts
Webinar: How to Overcome Assay Challenges Using Custom Recombinant AntibodiesWebinar: How to Overcome Assay Challenges Using Custom Recombinant Antibodies
Join this webinar to find out how custom-made recombinant antibodies can solve your challenges when designing and optimizing critical assays to support drug development, diagnostic assays or discovery studies.
Diagnostic Informatics Challenges – The Way ForwardDiagnostic Informatics Challenges – The Way Forward
This on-demand webinar provides a valuable look at the Diagnostic informatics challenges and issues that arise in the operation of the clinical laboratory.

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Gene Expression Analysis Market by Technology, Consumables, Services & Applications - Global Forecast to 2018
MarketsandMarkets

Over the years, the gene expression analysis market, comprising of instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of gene expression applications.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
High Throughput Screening (HTS) Market by Technology, Applications, and End Users - Forecast to 2018
MarketsandMarkets

Technological advancements and flourishing outsourcing industry likely to propel the growth of the global high throughput screening market. In this report, the global high throughput screening market has been segmented on the basis of technology, products, applications, end users, and geography.
Chromatography Resin Market by Application, Techniques & Type - Trends & Forecast to 2018
MarketsandMarkets

The chromatography resin market is expected to grow at a decent pace during the coming decade driven by its increasing application in monoclonal antibody production and food analytics.
Chromatography Accessories and Consumables Market by Types, Technology & End-users - Trends & Global Forecasts to 2018
MarketsandMarkets

The chromatography accessories and consumables market demands significant investments in R&D in order to constantly come up with new and innovative products and technologies.
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Scientific News
Brain-dwelling Worm in UK Man's Head Sequenced
Tapeworm removed from UK resident's brain reveals genetic secrets of an elusive Far East parasite.
Researchers Tease Out Glitches in Immune System's Self-Recognition
A new study revises understanding of how the process works and sheds light on autoimmune disease.
Crowdsourcing Science To Beat Psa
Scientists are hoping that crowdsourcing knowledge from the international science community will help them find the answer to a lethal kiwifruit disease.
Breakthrough in Managing Yellow Fever Disease
UC Riverside-led research could lead to antiviral therapeutics and better diagnostics to prevent spread of potentially fatal viral infection.
Themis Bioscience’s Vaccine Against Chikungunya Successful in Phase 1
Results presented at international conferences in Philadelphia and New Orleans.
Similarities and Striking Differences Found Between Mouse and Human Genome
Comparisons of both genomes’ inner workings may lead to a better use of mouse models.
New Strategy To Improve Stem Cell Transplantation
Research addresses hurdles to future transplant-based, gene-editing therapies that could help people with genetic blood diseases.
Molecular Event Mapping Opens Door to more in silico Tests
It is hoped that this new approach to mapping and predicting the impact of chemical compounds in the body could reduce the need for toxicity tests in animals.
Big Data Helps Pinpoint Possible New Stent Drug
Replacing the current drug used to coat artery-opening stents with a drug more targeted to the actual cause of stent disease could reduce blood clots and heart attacks.
Anti-Leukemia Drug May Also Work Against Ovarian Cancer
An antibody therapy already in clinical trials to treat chronic lymphocytic leukemia (CLL) may also prove effective against ovarian cancer – and likely other cancers as well.
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Business News
IBM Invests in Pathway Genomics to Help Personalize Consumer Health
The Watson-powered Pathway Panorama mobile app will be able to answer wellness related questions based on user’s genetics and devices.
European Metropolitan Area of Munich is Top Location for Biotechnology and Pharmaceutical Industries
New study by the Chamber of Industry and Commerce (IHK), the City of Munich and BioM confirms the importance of this sector.
IDRI Announces $11.9M Contract to Develop Thermostable TB Vaccine
Using freeze-drying process to overcome cold-chain transportation issues.
AbbVie Acquires Manufacturing Facility in Singapore
Further expands company's global operations for small molecule and biologics manufacturing capabilities in Asia.
Medgenics Announces Rare & Orphan Disease Research Collaboration with CHOP
Collaboration will bring together the premier pediatric genomics research organization, Center for Applied Genomics (CAG), with ex vivo gene therapy innovator, Medgenics, to discover and accelerate the development of new therapies for rare and orphan diseases.
CIRM and Medical University of Warsaw Collaborate
Poland and California announce international collaboration to advance stem cell research toward cures.
Vetter Announces Opening of Office to Support Growing Asian Healthcare Market
New Asia Pacific office will support customer relations and the development of new business.
Shire to Relocate Over 500 Jobs to Massachusetts
Establishes Lexington, Mass., as Company’s U.S. operational headquarters.
Catalent Acquires Micron Technologies
Company adds global particle size technology leader to Industry’s broadest bioavailability and delivery technology offerings.
Two New LIMS Case Studies Published
Case studies highlight the versatility of the Matrix LIMS at Castrol’s Lubricant Technology Centre and Cavendish Nuclear’s environmental laboratory.
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Events
Pharmacovigilance, Drug Safety
26 Nov 2014
Pharmacovigilance, Drug Safety ...
World Open Innovation Forum 20
26 Nov 2014
World Open Innovation Forum 20 ...
Sterilisation for Medical Devi
26 Nov 2014
Sterilisation for Medical Devi ...
CPhl - Elemental & Genotoxic I
26 Nov 2014
CPhl - Elemental & Genotoxic I ...

ePosters
Real Time Dual-Channel Multiplex SERS Ultradetection
University of Cambridge

Real time On-line multiplex SERS detection in a microfluidic device.
Detection in Environmental Samples of Enteroagregative Escherichia coli, stx-producing Escherichia coli and stx-converting Bacteriophage by RT- PCR: Preliminary Data
Istituto Zooprofilattico Sperimentale della Sardegna- Italy

The aim of this work was to collect epidemiological information concerning the presence of Enteroaggregative Escherichia coli, stx-producing Escherichia coli and stx2a-converting bacteriophage, in ruminants faeces.
METHOD DEVELOPMENT FOR THE SIMULTANEOUS DETERMINATION OF METHYLMERCURY AND INORGANIC MERCURY IN SEAFOOD
University of Barcelona, Universidade Federal do Rio Grande do Sul

This work reports the method development for the simultaneous determination of methylmercury (MeHg+) and inorganic mercury (iHg) species in seafood. The study focused on the extraction and quantification of MeHg+ by liquid chromatography coupled to on-line UV irradiation and cold vapour atomic fluorescence spectroscopy (LC-UV-HG-AFS), using HCl 4 mol L-1 as extractant agent.
Flow Enhancement and Dynamic of Microfluidic Base Biosensor
University Malaysia Pahang

The design of new biosesnor base on microfluidic system is presented. The design is consist of two chips, Microchannels chip and electrodes chip. By varying the size and optimizing the microchannels and electrode, the sensitivity of the biosensor will increase.
Relationships between Water Quality Constituents in the Delta and the Influence of Different Sources of Water
Richard Denton & Associates, Metropolitan Water District of Southern California

Analysis of detailed grab sample data from San Francisco Bay and Delta and development of regression relationships between EC, TDS and water quality constituents such as chloride, bromide, sodium, calcium, sulfate, alkalinity and hardness. The relationships in the interior Delta vary depending upon the percentage contributions from seawater, agricultural drainage and freshwater inflows.
Microextraction techniques combined with X-ray fluorescence spectrometry for determination of different metal ions in water
(a) Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland (b) Department of Chemistry, University of Girona, Campus Montilivi s/n, 17170-Girona, Spain (c) Institute of Eart

In present work new preconcentration procedures combining microextraction techniques and X-ray fluorescence spectroscopy were developed. Proposed methodologies are promising tools for multielemental analysis enabling detection of natural pollutants in different water samples.

HOMOGENEOUS ADCs BEARING TWO DIFFERENT PAYLOADS SHOW STRONG SYNERGY IN TUMOR KILLING
Dophen Biomed and TUBE Pharmaceuticals GmbH

We presented a one-pot reaction to prepare site-specific ADCs using available mABs on hand without re-engineering. We have identified a novel non-cleavable linker, which increases not only ADC stability, but also potency. We also demonstrate synergy in cancer cell killing of hybrid ADC loaded with two different toxins
Effect of exposure to stress conditions on propidium monoazide (PMA) - qPCR based enumeration of Campylobacter in broiler carcass rinses
1 Laboratory of Food Microbiology and Food Preservation, Dept Food Safety & Food Quality Faculty of Bioscience Engineering, Gent, Belgium 2 Institute of Public Health, Scientific service Food-borne pa

Evaluation and comparison of a developed PMA-qPCR Campylobacter enumeration method with the reference method, after exposure of the broiler rinse artificially contaminated with the bacteria to stress conditions.
Toward a Comprehensive Bottom-up and Top-down Analysis of the NIST Reference Monoclonal Antibody
1Protein Metrics Inc., San Carlos, CA USA, 2National Institute of Standards and Technology (NIST), Gaithersburg, MD USA

Development of ADC and other therapeutic proteins require careful characterization of sequence, post-translational modifications, sequence variants, and degradants. In this study, a NIST mAb interim reference material was analyzed by new bioinformatics tools (Byonic™, Byologic®, and Byomap™) allowing one to efficiently identify and quantify modifications down to trace levels.
Application of Central Composite Design (CCD) for the Optimization of Ultrasound-assisted Extraction (UAE) of Phenolics from Corn (Zea mays)
1Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora, 55281, Yogyakarta, Indonesia. 2Department of Ana

A new Ultrasound-assisted Extraction (UAE) of phenolic compounds from corn (Zea mays) has been optimized by means of chemometrics tool. The proposed method was validated and successfully applied to the analysis of phenolics content in several corn cultivars.
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Application Notes
Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
Malvern Instruments Limited

DSC data is useful in predicting the stability of a protein in solution. The Tm indicates thermostability, and Tm determination in different formulations is an approximate measure of the susceptibility to aggregation and other irreversible changes at lower temperatures.
Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis
Malvern Instruments Limited

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
GPC Characterization of Nylon using Formic Acid for Reduced Cost per Analysis
Malvern Instruments Limited

GPC/SEC can be used to characterize commodity or bulk manufactured polymers. Here we describe how the use of formic acid instead of HFIP as the dissolution solvent and/or mobile phase can lead to improvements in both cost per analysis and health and safety
Automated Illumina TruSeq® Nano DNA Sample Preparation
Tecan Group Ltd.

The TruSeq Nano DNA Sample Preparation Kit enables efficient investigation of samples where the amount of DNA available is limited. This low-input method generates excellent quality data from as little at 100 ng of DNA, allowing the study of samples with restricted DNA availability, for example from tumors, and helping to preserve precious sample material for use in future studies.
Double stranded DNA quantitation using Promega QuantiFluor® Dyes
Tecan Group Ltd.

Achieving selective and sensitive quantitation of double stranded DNA (dsDNA) using spectrophotometric methods can be problematic. Recognizing these difficulties, researchers have incorporated fluorescence-based quantitation techniques in their workflows to obtain the required sensitivity and target selectivity.
New Methodology for CHN Determination of Liquid Samples
Exeter Analytical

The utility of the Model 440 CHN microanalysis system for precise determination of percentage Carbon, Hydrogen and Nitrogen content of often demanding liquid samples is demonstrated.
Differentiation and characterization of subvisible particulates in therapeutic protein products
Malvern Instruments Limited

The formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due to the potential for increased immunogenicity.
An Introduction to Proteins in 30 minutes
Malvern Instruments Limited

In the biotechnology industry, the majority of research is directed towards characterizing the structure and function of proteins. New methods are continually being developed to accomplish this.
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
Simple sample preparation for the determination of vitamin D in serum by LC-MSMS
Tecan Group Ltd.

A growing number of laboratories have moved from the use of immunoassay methods to liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) for the determination of vitamin D. The advantage of the latter method is unparalleled specificity combined with high sensitivity, offering the potential for the determination of multiple analytes, such as 25OH-vitamin D3 and 25OH-vitamin D2.
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