Transcriptional and Posttranscriptional Regulation of HIV-1 Gene ExpressionThe transcription factors that control YAP gene expression are unknown. This study demonstrates that ß-catenin/TCF4 complexes bind a DNA enhancer element within the first intron of the YAP gene to drive YAP expression in CRC cells.
Cholinesterases, a Target of Pharmacology and ToxicologyThis review’s main focus is on cholinesterases as targets of toxins and drugs. The biochemistry of AChE and BuChE is also discussed. Drugs and toxins are divided in chapters according to target sites.
Launch of DIRECT - An Innovative Medicines Initiative Project for Personalized Medicine in DiabetesAcademia and the pharmaceutical industry working together in the fight against diabetes.
Estimation of drug-metabolizing capacity by CYP-genotyping and CYP-expressionThe lack of therapeutic effect of drugs or the appearance of undesired side-effects is partly caused by differences or changes in drug metabolism. This work aims to introduce an approach of combining CYP-genotyping and CYP-phenotyping tools to estimate patients’ drug-metabolizing capacity.
Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene SilencingThe gene silencing efficiency of mPEG-PLGA-PLL NPs is shown to be higher than that of commercially available transfecting agent Lipofectamine, while showing no cytotoxicity. The purpose of this work was to synthesize the novel biodegradable mPEG-PLGA-PLL NPs encapsulating siRNA, and examine the physical properties of NPs and in vitro siRNA release profile from NPs.
Study on Pivot-Point Vibration of Molecular Bond-Rupture Events by Quartz Crystal Microbalance for Biomedical DiagnosticsMolecular bond-rupture scanning is an effective method for the measurement of the energy level necessary to break a bond and distinguishing specific and nonspecific binding of biological molecules.
FDA Approves Gen-Probe's PROGENSA® PCA3 AssayCompany reveals first molecular test to help determine the need for repeat prostate biopsies in men who have had a previous negative biopsy.
An ice age flower 30,000 year old revived - resurrection of seed from permafrostIt was an Ice Age squirrel's treasure chamber, a burrow containing fruit and seeds that had been stuck in the Siberian permafrost for over 30,000 years. From the fruit tissues, a team of Russian scientists managed to resurrect an entire plant in a pioneering experiment that paves the way for the revival of other species.
NIH Common Fund Researchers Uncover Structure of Important Target for Drug DesignResearchers have uncovered a potent class of small molecules that selectively turn on the S1P1 receptor.
Two Decades of Studying Non-Covalent Biomolecular Assemblies by Means of Electrospray Ionization Mass SpectrometryMS has evolved to impact a wide range of applications in structural biology. This paper charts some of the milestones in MS development as they pertain to the study of non-covalent complexes, and the novel applications they have enabled.
