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Webcasts
Webcasts - The Bru-seq Technology Platform for Nascent RNA analysisThe Bru-seq Technology Platform for Nascent RNA analysis
Mats Ljungman, Professor, University of Michigan will present a set of novel techniques to analyze many aspects of gene expression based on the capturing of nascent RNA.
Webcasts - Drug Sensitivity and Resistance Testing Platform for Personalized Medicine at the Institute for Molecular Medicine Finland (FIMM)Drug Sensitivity and Resistance Testing Platform for Personalized Medicine at the Institute for Molecular Medicine Finland (FIMM)
Jani Saarela, Institute for Molecular Medicine, speaking at Screening Europe 2015

Market Reports
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
Single Cell Omics 2011
Select Biosciences Ltd

The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Multiplexed Diagnostics 2010
Select Biosciences Ltd

The multiplexed diagnostics market has grown rapidly and generated sales of approximately $2.4 billon in 2009, but is now balanced on multiple tipping points.
Genomics, Proteomics and Metabolomics in Diagnostics: Market landscape, innovative technologies and future outlook
Business Insights

There has been a significant transition in the diagnostic techniques created with increasing technological innovations. In the future, the focus will be on genetic study and disease predisposition, which will test patients' probability of acquiring a disease or a disorder, enabling precautionary steps.
Scientific News
New Treatment for Pancreatic Cancer
Researchers at Purdue University have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis.
Plasma Biomarkers for Breast Cancer Diagnosis
Plasma lipidomics profiling identified lipid biomarkers in distinguishing early-stage breast cancer from benign lesions.
How Different People Respond To Aspirin
Study findings could be used to help identify those who would benefit most from aspirin use.
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
A Metabolic Twist that Drives Cancer Survival
A novel metabolic pathway that helps cancer cells thrive in conditions that are lethal to normal cells has been identified.
Liver-On-Chip Tracks Dynamics of Cellular Function
Hebrew University’s liver-on-chip platform is uniquely able to monitor metabolic changes indicating mitochondrial damage occurring at drug concentrations previously regarded as safe.
Living Off the Fat of the Land
Do cancer cells synthesize the parts for new cells or scavenge them from the environment?
Liver Disease, Obesity Linked
Kanazawa University researchers find similarities in the impeded signalling between central insulin activity and glucose production in the liver for both obese mice and mice that have had the vagus nerve removed.
Decoding Ties Between Vascular Disease, Alzheimer’s
NIH consortium uses big data, team science to uncover complex interplay of factors.
Gene Identified that May Worsen Cancer Outcome
Some patients with breast cancer, lung cancer and leukaemia seem to fare poorly after treatment because of the effects of a particular gene, a new study finds.
Business News
InfanDx AG, LSI Initiates Clinical Study
Company has initiated clinical study for metabolomic perinatal brain damage test.
Synta, Madrigal Announce Merger
Merger will create a company focused on the development of novel small-molecule drugs addressing major unmet needs in cardiovascular-metabolic diseases and non-alcoholic steatohepatitis.
Gilead Acquires Nimbus Therapeutics’
Nimbus Therapeutics will receive an upfront payment of $400 million, with the potential to receive an additional $800 million in development-related milestones over time.
Baylor Miraca Announces Strategic Partnership with Diversigen
Company has announced a strategic partnership to provide its customers access to broad range of targeted genomics and metabolomics services.
Diversigen, Baylor Miraca Announces Strategic Partnership
Diversigen to offer both metagenomic/microbiome analysis and host genetics for customers interested in a broader understanding of health and disease in the whole human.
Pharmaron Acquires Quotient Bioresearch
Company has announced that it has acquired Quotient Bioresearch to enhance service offerings and increase presence in global markets.
Scientists Honored for Important Research on Mass Spectrometry
William Gilliland Jr. and Nalaka Rannulu recently received the Best Poster Awards at the 2015 CASSS Mass Spec Symposium.
Innovate UK Support for SimOmics
A University of York spin-out backed by the Royal Academy of Engineering’s Enterprise Hub, has been awarded a £300,000 grant from the UK’s innovation agency Innovate UK.
It is All About the Product, Right?
Technology Networks met with Waters Corporation at its head office in Milford, MA to better understand the factors they use to drive business success.
Sanofi, Global Genomics Group Partner
Global Genomics Group ("G3") announced that it has entered into a research collaboration with Sanofi to identify new signaling pathways and targets involved in the etiology of coronary artery disease.

Events
3rd Metabolomics - Advances &
25 May 2016
3rd Metabolomics - Advances & ...
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Metabolomics India 2016
26 May 2016
Metabolomics India 2016 ...
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HPLC 2016
19 Jun 2016
HPLC 2016 ...
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Agrigenomics India 2016 - 2nd
19 Aug 2016
Agrigenomics India 2016 - 2nd ...
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ePosters
Assessing Diversity in Cassava through the Application of Metabolomics
aSchool of Biological Sciences, Royal Holloway University of London, Egham, UK bInternational Center for Tropical Agriculture, CIAT

In the present study metabolomic platforms have been established for Cassava and used to assess the biodiversity present in Cassava germplasm collections and elucidate underlying biochemical mechanisms associated with traits of interest.
Metabolomic profile of multiple sclerosis patients by means of 1H-NMR analysis
1 Department of Biomedical Sciences, University of Cagliari, Italy 2 Department of Public Health, Clinical and molecular medicine, Cagliari, Italy 3 Department of Medical Sciences, Cagliari, Italy

Multiple sclerosis (MS) is a chronic disease characterized by a high level of heterogeneity. Metabolomics is an “-omics” approach with the potential to discover new biomarkers.
Application of metabolomics in drug-resistant epilepsy research
1 Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. 2 Department of Medical Sciences, 3 Department of Public Health, Clinical and molecular medicine

Metabolomics represents an important tool for biomarker discovery in drug-resistant epilepsy and for the study of the pathophysiology of this disease.
Changes in the metabolic profile of urine from mink during early pregnancy
Aarhus University, Department of Animal Science

Metabolic profiling of urine from pregnant mink showed that ß-oxidation as well as protein metabolism is changed during pregnancy in mink and it is hypothesized that the changes occur to ensure optimal nutrition of the foetuses.
A KNIME Pipeline for the Analysis of GC-MS Data in Metabolomics
1Department of Biomedical Sciences, Section of Pathology, University of Cagliari, Italy; 2Department of Life and Environmental Sciences, High Resolution Mass Spectrometry Laborat

A KNIME pipeline was developed to perform pre-processing of GC-MS data in an automated way and applied to a Inflammatory bowel diseases case study
Metabolic response to everolimus in patient-derived xenografts of triple negative breast cancer
1Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Trondheim, Norway, 2Department of Medical Imaging, St Olavs University Hospit

Everolimus treatment metabolic effects on TNBC PDX models were investigated using MR spectroscopy. PLS-DA successfully discriminated treated from controls and PDX expressing INPP4B and not. LMM revealed significant differences in 4/17 metabolites and two metabolite ratios between treated and controls.
PredRet: Prediction of Retention Time by Direct Mapping between Multiple Chromatographic Systems
Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all’Adige (TN), Italy.; Department of Stress and Developmental Biology, Leibniz Institute

Retention time (RT) information is under-utilized in LC-MS based metabolomics and sharing of RTs between systems is not currently possible. PredRet is a new system that allows highly accurate mapping and prediction of RTs between LC systems.
Profiling of metabolomic changes induced by testosterone esters in pig plasma and urine
Veterinary Research Institute, Brno, Czech Republic

In this study, metabolic fingerprinting to discriminate between pigs treated with 17ß-testosteron esters and control animals has been investigated. Multivariate statistical analysis showed significant metabolic differences between test and control groups on day 28 after aplication of the testosterone hormonal preparation.
A Novel Bioluminescent HTS Method for Rapid NAD(P)/NAD(P)H Detection Poster
Promega Corporation

Nicotinamide adenine dinucleotides (NAD+, NADH, NADP+ and NADPH) are fundamental co-factors of cellular energy metabolism. These dinucleotides are essential for macromolecule biosynthesis and the maintenance of the cellular redox potential. Our new rapid, easy-to-use assays for measuring dinucleotides are convenient tool for investigating their role in these processes.
ROS-Glo™ H2O2 Assay: A Luminescent Assay for Detection of Reactive Oxygen Species Poster
Promega Corporation

H2O2 is a reactive oxygen species (ROS) that is measured in cells as a marker of oxidative stress. It is also measured as a marker of enzyme activities that either consume or produce H2O2. It is desirable to screen chemical compounds for their capacity to alter H2O2 levels in cultured cells or for their effects on H2O2 levels in enzyme reactions.
Application Notes
Multiplex Genotyping of Human Reference DNA Samples with Pharmacologically Important Single Nucleotide Polymorphisms using the IntelliQube® from Douglas Scientific
Douglas Scientific

This study demonstrates the ability of the IntelliQube along with Array Tape®, to successfully achieve two multiplexed SNP genotyping results in a single well and decrease thermal cycling times without compromising data quality. The combination of achieving two results per reaction well and shortened cycling times dramatically increases overall throughput.
Automated Sample Preparation for the Monitoring of Ethanol Metabolites in Urine by LC-MS/MS
Beckman Coulter Life Sciences


Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation

Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation

This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
Quantitative Determination of Total Bile Acids with a Thermo Scientific Varioskan Flash Multimode Reader Using a Kinetic Enzyme Cycling Assay
Thermo Fisher Scientific

Serum total bile acids (TBA) level is a long-established and accepted indicator of liver diseases. This application note presents a simple photometric measurement of serum TBA.
Optimization of Instrument Settings and Measurement Parameters for Kinetic Fluorometric and Luminometric Assays
Thermo Fisher Scientific

When fluorometric and luminometric assays are performed in microplate format, a high number of samples can be analyzed at a time. The speed of the reaction kinetics of the assay determines the requirements for the detection instrument and measurement parameters for achieving the best possible performance of the assay.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific

The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays
Thermo Fisher Scientific

A number of different reagents can be used to perform photometric cell proliferation and viability assays. A microplate photometer can quickly determine which reagent is the best choice for an assay and then optimize the assay. Significant time savings and productivity gains can be achieved with this tool.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific

The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Promega’s ADP-Glo™ Kinase Assay performed on BMG LABTECH’s PHERAstar FS and POLARstar Omega
BMG Labtech

The PHERAstar FS as well as the POLARstar Omega offer the ability to perform the ADP-Glo™ assay from Promega in a 384-well format. The ADP-Glo™ Kinase Assay is a homogenous luminescent assay to detect ADP in concentrations ranging from 1 mM to 0.01 µM. Instrument settings and standard ATP/ADP curves over a wide concentration range are presented for both the PHERAstar FS and the POLARstar Omega.
SELECTBIO

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