Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Research into Dietary Leucine

Published: Tuesday, July 19, 2011
Last Updated: Tuesday, July 19, 2011
Bookmark and Share
Metabolon, Inc. announces the publication of “Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism” in PLoS One.

Non-targeted biochemical profiling (metabolomics) provided insight into the biochemical mechanisms of leucine’s effects on metabolism. The study was carried out by lead investigator C. Ron Kahn, M.D. and colleagues at the Joslin Diabetes Center and Harvard Medical School and Metabolon.

The researchers evaluated the effects of leucine supplements on metabolism and insulin signaling in a mouse model of insulin resistance and metabolic syndrome. They showed that a dietary increase in leucine, a branched chain amino acid, improved glucose tolerance, prevented fatty liver, reduced obesity-induced adipose tissue inflammation and rescued insulin signaling in muscle, liver and fat. By using a global metabolic profiling approach the investigators were able to follow leucine metabolism in serum, liver, fat and muscle in the high fat diet-(HFD)-induced obesity mice. The metabolomic analysis showed leucine supplementation resulted in changes in multiple metabolic pathways involving protein, lipid and carbohydrate metabolism. Notably, leucine addition to a high fat diet restored the metabolic profile of the animals to the profile found in mice fed a control diet.

Commenting on the study, collaborator, Dr. Kahn, Head of Section on Integrative Physiology and Metabolism at the Joslin Diabetes Center and Iacocca Professor of Medicine at Harvard Medical School, said, “These findings point to the importance of even small changes in diet on metabolism and diabetes risk, and how important it is to be able to measure the full range of metabolite changes that altering the diet can affect.”

The article has been published on-line in PLoS One and may be accessed below.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Metabolon Launches Strategic Outsourcing Programs Focused On Disease Metabolism
Metabolon’s partners will collaborate toward shared objectives through this program.
Monday, October 15, 2012
Metabolon Files Patent Infringement Lawsuit against Stemina
The lawsuit requests monetary damages as well as an order permanently enjoining Stemina from continued acts of infringement.
Tuesday, August 28, 2012
Metabolon Strengthens Metabolomics Leadership with Acquisition of Lipomics Technologies
Gains proprietary lipids technology platform and further opportunities for diagnostics, personalized medicine and commercial services.
Friday, August 03, 2012
Metabolon Technology Now Available in Germany
The Helmholtz Zentrum Muenchen, Research Center for Environmental Health in Neuherberg, Germany, has successfully completed Metabolon’s validation requirements.
Friday, July 13, 2012
Metabolon’s Shanghai Jiao Tong University Lab Receives Validation
The joint metabolomics laboratory passed the quality control processes and has officially started operation.
Monday, May 14, 2012
Takeda and Metabolon Initiate Research Collaboration
Multiyear research alliance to discover novel targets and biomarkers.
Wednesday, April 18, 2012
Metabolon Awarded Analytical Methods Patent
The patented method enables the researcher to process, analyze and interpret data more efficiently.
Thursday, March 29, 2012
Metabolon Receives Accreditation by College of American Pathologists
Metabolon, Inc. announces that they have received laboratory accreditation from the College of American Pathologists (CAP).
Tuesday, December 06, 2011
Metabolomics Insight into Periodontal Disease Published in the Journal of Dental Research
Data reveal altered host-bacteria interactions associated with periodontitis.
Monday, October 24, 2011
Metabolon and SJTU Open Metabolomics Lab in China
Shanghai facility is company’s first foray into Asia.
Tuesday, October 18, 2011
Genome Wide Association Study Published in Nature
Metabolon, Inc. announces the publication of “Human Metabolic Individuality in Biomedical and Pharmaceutical Research” in the journal Nature.
Tuesday, September 20, 2011
Metabolon Secures $13 Million in Series D Financing
New investor Keating Capital, Inc. joins existing investors including Sevin Rosen Funds, Aurora Funds, Harris & Harris Group, Syngenta Ventures, Fletcher Spaght and Fulcrum Financial Partners in the round.
Tuesday, August 30, 2011
Two Studies Provide Insight into Kidney Cancer
Metabolon, Inc. announces the publication of studies in two peer-reviewed journals that support the use of metabolomics in the diagnosis and treatment of kidney cancer.
Tuesday, August 16, 2011
USPTO Grants Two New Patents to Metabolon
Metabolon currently holds 17 US Patents related to its biochemical profiling methods, data analysis solutions and biomarkers for disease and toxicity.
Monday, June 20, 2011
Metabolon Awarded Patent in Metabolomics Methods for Drug Discovery
Metabolon, Inc. announces that it was awarded US Patent 7,910,301 “Methods for Drug Discovery, Disease Treatment and Diagnosis Using Metabolomics” by the United States Patent and Trademark Office.
Tuesday, May 17, 2011
Scientific News
Fat Cells That Amplify Nerve Signals in Response to Cold Also Affect Blood Sugar Metabolism
Researchers at UTSW have found that the protein connexin 43 forms cell-to-cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.
Adipose Tissue Secretes Factors That Activate Metabolism
Study finds brown adipose tissue secretes signalling factors that activates metabolism of fat and carbohydrates.
Gene Deletion Reveals Cell Secrets
Researchers have deleted 174 genes in yeast to analyse the effect of individual gene deletion.
Targeting Fat to Treat Cancer
Researchers develop novel cancer treatment that halts fat synthesis in cells, stunting tumors.
NIH Study Finds Link Between Depression, Gestational Diabetes
Researchers at NIH have discovered that the depression in early pregnancy doubles risk for gestational diabetes, and gestational diabetes increases risk for postpartum depression.
Gut Pathogens Thrive on Body's Tissue-Repair Mechanism
Researcher have discovered that harm caused by pathogens in the intestinal tract benefit from immune system response to damaged intestinal lining.
Cancer's Taste for Fat
Researchers discovered signalling pathway for fat burning is disrupted in certain cancers.
‘Tracking Bugs’ Reveal Secret of Cancer Cell Metabolism
Unexpected finding shows instead of throwing away valuable nutrients, the cells squeeze out every last drop of energy.
Ginger Nano-Lipid Particles May Improve Cancer Treatment
Edible ginger-derived nano-lipids show promise for effectively targeting and delivering chemotherapeutic drugs used to treat colon cancer.
Genetic Diversity of Enzymes Alters Metabolic Individuality
ToMMo scientists have shown that genetic polymorphisms, structural location of mutation and effect for phenotype correlate with each other.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!