Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

SRI Establishes Metabolite Standards Synthesis Center for NHLBI

Published: Tuesday, January 07, 2014
Last Updated: Tuesday, January 07, 2014
Bookmark and Share
Company receives $4.5 million contract from the NHLBI to establish a Metabolite Standards Synthesis Center to prepare molecules for researchers to use in the field of metabolomics.

Enormous amounts of information can be gleaned from comprehensively characterizing thousands of the chemical byproducts of metabolism called metabolites. Metabolomics offers new ways for researchers to detect disease, monitor disease progression and response to therapy, stratify patients based on biochemical profiles, and identify new biomarkers and drug targets. A major roadblock in metabolomics research, however, is that researchers often do not have access to the metabolite standards they need to confirm and quantify their results.

“Currently, more than half of all human metabolites are unavailable, and many metabolites have never been synthesized or their structures have only been speculated, and therefore these important molecules are not available to researchers,” said Mary Tanga, Ph.D., director of the Center for Chemical Biology in SRI Biosciences and principal investigator of SRI’s Metabolite Standards Synthesis Center. “Researchers can pursue the answers to important questions if they actually have the compounds. The reference standards that SRI scientists will synthesize are critical to advances in metabolomics.”

SRI’s Metabolite Standards Synthesis Center will begin to fill the gap by creating a library of thousands of metabolites that will be made available to the scientific community. Synthesized metabolites function as standards for research and are critical for confirming the identity of previously unknown components in biological samples such as blood or urine. Studies of these small molecule metabolites will improve understanding of disease processes, reveal new biomarkers of disease, and provide new ways of monitoring therapeutic outcomes.

The SRI contract is part of a multicomponent program developed by the NIH Common Fund Metabolomics Program. The overall goal of the program is to increase metabolomics research capacity in the United States by supporting infrastructure expansion, training, technology development, and reference standards synthesis.

Requests for compound synthesis should be submitted to the Metabolomics Workbench. Upon NIH approval, SRI chemists will prepare sufficient material for the original requester and future projects.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
New ACE-inhibiting Molecule Found in the Asparagus
Scientists have determined that sulfur-containing compounds in plants can inhibit ACE.
A Metabolic Master Switch Underlying Human Obesity
Researchers find pathway that controls metabolism by prompting fat cells to store or burn fat.
Shedding Light On Century-Old Biochemical Mystery
Yale scientists have used magnetic resonance measurements to show how glucose is metabolized in yeast to answer the puzzle of the “Warburg Effect.”
PTR-MS Breath Test Shows Potential for Detecting Liver Disease
Researchers at the University of Birmingham have published results that suggest a non-invasive breath test for liver disease using an IONICON PTR-MS.
Metabolon and BCM Show Metabolomics May Play Key Role in Precision Medicine
Metabolon’s technology enhances understanding of genetic data and improves health assessment in newly published study.
Newly Discovered Cells Restore Liver Damage in Mice Without Cancer Risk
The liver is unique among organs in its ability to regenerate after being damaged. Exactly how it repairs itself remained a mystery until recently, when researchers supported by the NIH discovered a type of cell in mice essential to the process
Study Finds Cutting Dietary Fat Reduces Body Fat More than Cutting Carbs
In a recent study, restricting dietary fat led to body fat loss at a rate 68 percent higher than cutting the same number of carbohydrate calories when adults with obesity ate strictly controlled diets.
Inappropriate Medical Food Use in Managing Patients with a Type of Metabolic Disorder
Researchers have proposed that there is a need for more rigorous clinical study of dietary management practices for patients with IEMs, including any associated long-term side effects, which may in turn result in the need to reformulate some medical foods.
Medical Researchers a Step Closer to Developing Anti-Obesity Pill
A weight loss pill could soon be possible thanks to the work of Deakin University medical researchers.
Engineered Bacterium Produces Important Industrial Chemical
A Korean research team has reported the production of 1,3-diaminopropane via fermentation of an engineered bacterium.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!