Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Diabetes Duration and Severity Associated with Brain Atrophy

Published: Wednesday, April 30, 2014
Last Updated: Wednesday, April 30, 2014
Bookmark and Share
Type 2 diabetes may be associated with brain degeneration, according to a new multicenter study published online in the journal Radiology.

The study also found that, contrary to common clinical belief, diabetes may not be directly associated with small vessel ischemic disease, where the brain does not receive enough oxygenated blood.

"We found that patients having more severe diabetes had less brain tissue, suggesting brain atrophy," said lead author R. Nick Bryan, M.D., Ph.D., professor of radiology at the Perleman School of Medicine at the University of Pennsylvania. "They did not seem to have more vascular disease due to the direct effect of diabetes."

According the American Diabetes Association (ADA), nearly 26 million people in the United States have diabetes, and 1.9 million more are diagnosed with the disease each year. Type 2 is the most common form of diabetes. In type 2 diabetes, either the pancreas does not produce enough insulin or the cells ignore the insulin that is produced. The ADA estimates that, based on current trends, as many as one in three American adults will have diabetes in the year 2050.

"As diabetes becomes more common, better understanding of the disease and its management becomes even more important in order to minimize its effect on patient health," Dr. Bryan said.

For the study, Dr. Bryan and colleagues used magnetic resonance imaging (MRI) to investigate the association between severity and duration of type 2 diabetes mellitus and brain structure in 614 patients (mean age 62 years) at four participating centers (University of Minnesota, Minneapolis, Minn.; Wake Forest Medical School, Winston-Salem, N.C.; Columbia University, New York, N.Y.; and Case Western Reserve University, Cleveland, Ohio). The mean duration of disease in the study group was 9.9 years. The researchers specifically tested whether more severe diabetes was inversely correlated with brain volumes and positively correlated with ischemic lesion volumes.

The results showed that longer duration of diabetes was associated with brain volume loss, particularly in the gray matter. However, the study found no association of diabetes characteristics with small vessel ischemic disease in the brain.

"Diabetes duration correlated primarily with brain atrophy," Dr. Bryan said. "Stated another way, our results suggested that, for every 10 years of diabetes duration, the brain of a patient with diabetes looks approximately two years older than that of a non-diabetic person, in terms of gray matter volume."

The researchers noted that their findings may have implications for future decline of cognitive function in patients with diabetes and raise the possibility that such cognitive changes might not be strongly related to vascular dementia but to neurodegenerative disorders, such as Alzheimer's disease.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Targeting Fat to Treat Cancer
Researchers develop novel cancer treatment that halts fat synthesis in cells, stunting tumors.
NIH Study Finds Link Between Depression, Gestational Diabetes
Researchers at NIH have discovered that the depression in early pregnancy doubles risk for gestational diabetes, and gestational diabetes increases risk for postpartum depression.
Gut Pathogens Thrive on Body's Tissue-Repair Mechanism
Researcher have discovered that harm caused by pathogens in the intestinal tract benefit from immune system response to damaged intestinal lining.
Cancer's Taste for Fat
Researchers discovered signalling pathway for fat burning is disrupted in certain cancers.
‘Tracking Bugs’ Reveal Secret of Cancer Cell Metabolism
Unexpected finding shows instead of throwing away valuable nutrients, the cells squeeze out every last drop of energy.
Ginger Nano-Lipid Particles May Improve Cancer Treatment
Edible ginger-derived nano-lipids show promise for effectively targeting and delivering chemotherapeutic drugs used to treat colon cancer.
Genetic Diversity of Enzymes Alters Metabolic Individuality
ToMMo scientists have shown that genetic polymorphisms, structural location of mutation and effect for phenotype correlate with each other.
Absolute Quantification of Mitochondrial Metabolites
Scientists have developed a method to quickly isolate and systematically measure metabolite concentrations within mitochondria.
Vitamin C May Boost Leukemia Treatment
Studies show that supplementing an epigenetic cancer drug with vitamin C enhanced the drug's effectiveness.
Demonstrating LNP Delivery of CRISPR Components
Intellia has presented data demonstrating in vivo gene editing ising liquid nanoparticles (LNPs) to deliver CRISPR/Cas9.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!