Corporate Banner
Satellite Banner
Metabolomics & Lipidomics
Scientific Community
Become a Member | Sign in
Home>News>This Article

Salk Institute Receives $3M Gift for Ageing Research

Published: Friday, May 23, 2014
Last Updated: Friday, May 23, 2014
Bookmark and Share
The gift from the Glenn Foundation for Medical Research will allow the Institute to continue conducting research to understand the biology of normal human aging and age-related diseases.

The gift will support the research of the Glenn Center for Aging Research at the Salk Institute, which was established in January 2009, with a $5 million gift from the Glenn Foundation. The center draws from eleven of Salk's leading laboratories specializing in genetic analysis, stem cell biology and metabolism research.

"The biology of aging underlies all the major human diseases," Glenn Foundation President Mark R. Collins says. "To understand the fundamental aging process and to intervene is to delay the onset of disease, to extend the healthful years of life and reduce costs to society."

Combined with the Salk Institute's uniquely collaborative culture, the support of the Glenn Foundation positions the center to rapidly advance aging research and shed light on ways to stave off a multitude of age-related diseases, such as cancer, cardiovascular disease, diabetes and Alzheimer's Disease.

The Salk center focuses on a three-level approach: whole systems biology, organ biology and cellular aging biology. Expertise in all three areas is required to understand aging, age-related disease and the difference between healthy and pathological aging.

The center is led by Salk professors Jan Karlseder and Martin Hetzer, both of Salk's Molecular and Cell Biology Laboratory. A focus of Karlseder's lab is to understand the functions of telomeres, which are the protein-DNA complexes at the ends of linear chromosomes and are crucial in DNA replication, tumor suppression and aging. "A better understanding of telomere shortening will lead to an ability to influence the aging process, and as a result to the restriction of cancer cell growth," says Karlseder, holder of Salk's Donald and Darlene Shiley Chair.

Hetzer's lab is using emerging technologies to study how different organs of the adult body are maintained. They are particularly interested in identifying the mechanisms underlying the decline of heart and brain function during aging and in understanding how the body's own repair strategies can be stimulated to enhance healthy aging.

For example, the Hetzer lab's recent findings of extremely long-lived cellular structures in the brain revealed new insights into how neurons can function over the entire lifespan of an organism without ever being replaced. These findings have direct implications for our understanding of Alzheimer's disease and other neurodegenerative disorders.

"We hypothesize that the failure to maintain proper levels and functional integrity of long-lived proteins in non-proliferative cells could be a major contributor to age-related changes in cell and tissue function," says Hetzer, holder of Salk's Jesse and Caryl Philips Foundation Chair. "If successful, our studies hold the promise of revealing new principles of protein homeostasis and age-related loss of cell function, both during 'normal' aging and in age-related disease."

The center will use the Glenn Foundation gift to further support research into the biology of normal aging with the objective of developing interventions to delay its onset and progression. The center was the third of eight institutions to join the Glenn Consortium for Research in Aging, which includes Harvard Medical School, MIT Department of Biology, Princeton University and Stanford School of Medicine.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Tumor Suppressor Pulls Double Shift as Reprogramming Watchdog
Salk study finds that the tumor suppressor p53 not only stops cells that could become cancerous but also controls somatic cell reprogramming.
Wednesday, August 12, 2009
A Novel Human Stem Cell-Based Model of ALS Opens Doors for Rapid Drug Screening
A study at the Salk Institute confirmed that dysfunctional human astrocytes turn against their charges and kill off healthy motor neurons.
Wednesday, December 10, 2008
Scientific News
New Treatment for Obesity Developed
Researchers at the University of Liverpool, working with a global healthcare company, have helped develop a new treatment for obesity.
How Cell Growth Triggers Cell Division
Researchers in Jan Skotheim's lab have discovered a previously unknown mechanism that controls how large cells grow, an insight that could one day provide insight into attacking diseases such as cancer.
Metabolomic Platform Reveals Fundamental Flaw in Common Lab Technology
A new study led by scientists at The Scripps Research Institute (TSRI) shows that a technology used in thousands of laboratories, called gas chromatography mass spectrometry (GC-MS), fundamentally alters the samples it analyzes.
Newly Identified Biochemical Pathway Could Be Target for Insulin Control
Researchers at Duke Medicine and the University of Alberta are reporting the identification of a new biochemical pathway to control insulin secretion from islet beta cells in the pancreas, establishing a potential target for insulin control.
Dirty,Crusty Meals Fit for (Long-Dormant) Microbes
Researchers apply the latest analytical techniques to further our understanding of desert biocrusts.
CSI -- On The Metabolite's Trail
Bioinformaticians at the University of Jena make the most efficient search engine for molecular structures available online.
Developing a Breathalyzer-Type Low Blood Sugar Warning Device For Diabetes
A multidisciplinary team of researchers at Indiana University-Purdue University Indianapolis has been awarded a $738,000 National Science Foundation grant to develop a breathalyzer-type device to detect the onset of hypoglycemia, or low blood sugar episodes, in people with diabetes.
Identifying The 'Dimmer Switch' Of Diabetes
University of Alberta research gives new insight into what causes Type 2 diabetes.
10 to 1: Bugs Win in NASA study
Bugs are winning out, and that's a good thing according to NASA's Human Research Program.
MYC Oncogene Disrupts Cancers Rhythm
Findings inform time-dependent treatment for reducing side effects and increasing effectiveness of cancer medications.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos