|A Novel Benchtop Time-of-Flight GC-MS System for High Performance Analysis of Human Urine|
David E. Alonso, Joseph E. Binkley, Lorne M. Fell
A workflow was developed and implemented for the effective comparison of urine. It involved the preparation of stable compounds through derivatization, data acquisition using a high performance benchtop TOFMS, comprehensive data processing (NonTarget Deconvolution™), and quick retrospective analysis of rich datasets using Target Analyte Finding.
|Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery |
Richard Lee,1 Vitaly Lashin,2 Andrey Paramonov,2 Alexandr Sakharov,2 Alexey Aminov2
A discussion of a new informatics solution that addresses common challenges in metabolite identification and characterization--from LC/MS data processing and metabolites prediction to reporting and databasing of assembled biotransformation knowledge.
|Molecular Abnormalities in Schizophrenia: Neurotransmission, Oxidative Stress, and Apoptosis|
Elizabeth J. Want,1 Hendrik Wesseling, 2 Elaine Holmes, 1 and Sabine Bahn 2
A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.
|Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.|
Deirdre M. Kavanagh, Alison Dun, Rory R. Duncan, and Colin Rickman.
Single molecule imaging of the tSNARE proteins involved in insulin secretion.
|Diagnosing Coral disease with Metabolomic Markers|
Application of untargeted metabolomics for the identification of disease markers in corals
|Analysis of Petroleum Products Using Comprehensive Two-Dimensional Gas Chromatography (GCxGC) with Both Time-of-Flight MS and Flame Ionization Detectors|
Christina N. Kelly, Jonathan D. Byer, David E. Alonso, Lorne E. Fell, Joseph E. Binkley
Several possible configurations were tested to develop a workflow which would allow either subsequent or simultaneous acquisitions of GC×GC TOFMS and FID data on the same GC×GC instrument for petroleum analysis.
|Assessing Diversity in Cassava through the Application of Metabolomics|
Margit Drapala, Elisabete Carvalhoa, Laura Perez-Fonsa, Elliott Pricea, L. Augusto Becerra Lopez-Lavalleb, Paul D. Frasera
In the present study metabolomic platforms have been established for Cassava and used to assess the biodiversity present in Cassava germplasm collections and elucidate underlying biochemical mechanisms associated with traits of interest.
|Metabolomic profile of multiple sclerosis patients by means of 1H-NMR analysis|
Federica Murgia1, Lorena Lorefice 2 ,Eleonora Cocco2, Luigi Barberini2, Simone Poddighe1, Maria Rita Murru2, Raffaele Murru2, Jessica Frau2, MD Giuseppe Fenu2, MD, Giancarlo Coghe2, Francesco Del Carratore1, Luigi Atzori1, Maria Giovanna Marrosu3
Multiple sclerosis (MS) is a chronic disease characterized by a high level of heterogeneity. Metabolomics is an “-omics” approach with the potential to discover new biomarkers.
|Application of metabolomics in drug-resistant epilepsy research|
Federica Murgia1, Simone Poddighe1, Francesco Del Carratore1, Lorenzo Polizzi2, Antonella Muroni2, Luigi Barberini3, Monica Puligheddu3, Francesco Marrosu2 , Luigi Atzori1
Metabolomics represents an important tool for biomarker discovery in drug-resistant epilepsy and for the study of the pathophysiology of this disease.
|Changes in the metabolic profile of urine from mink during early pregnancy|
Mette Skou Hedemann
Metabolic profiling of urine from pregnant mink showed that ß-oxidation as well as protein metabolism is changed during pregnancy in mink and it is hypothesized that the changes occur to ensure optimal nutrition of the foetuses.
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