Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Findings on the Formation of Body Pigment

Published: Thursday, October 22, 2009
Last Updated: Thursday, October 22, 2009
Bookmark and Share
The skin's pigment cells can be formed from completely different cells than has hitherto been thought, a new study from the Swedish medical university Karolinska Institutet shows. The results, which are published in the journal Cell, also mean the discovery of a new kind of stem cell.

The body's pigment gives essential protection against UV radiation. It is made up of a substance called melanin, which is produced by pigment cells in the skin called melanocytes. According to the established theory of body pigmentation, these melanocytes bud off from the spinal cord at an early foetal stage and then migrate to the skin where they remain for the rest of their lives.

Scientists at Karolinska Institutet in Stockholm have now shown that most melanocytes actually appear later on in foetal development from an immature cell type that exists in the skin's nerve fibres. These cells, called Schwann cell precursors (SCPs), can also be found in adults. In addition to this, the scientists have demonstrated how neuronal damage in adults can excite the maturation of melanocytes to form hyperpigmentation around the affected nerves.

"Our findings can provide new knowledge of how changes in skin pigmentation occur, not least of the links that have been observed between neurological disease and changes in pigmentation," says Professor Patrik Ernfors, who led the study.

Their results also shed new light on SCP cells, which were previously seen as an immature form of supportive cells the nervous system. The researchers describe how a change in cell signalling can make the SCP cells in the skin develop into pigment cells instead, and argue that SCP cells are really a kind of stem cell.

"This can help science to understand the development of diseases such as melanoma," says Professor Ernfors. "We've always believed that it develops from melanocytes, but maybe it actually originates in the SCP cells."
Publication

Igor Adameyko, Francois Lallemend, Jorge B Aquino, Piotr Topilko, Jorge A Pereira, Thomas Müller, Nicolas Fritz, Anna Beljajeva, Makoto Mochii, Isabel Liste, Dmitry Usoskin, Ueli Suter, Carmen Birchmeier and Patrik Ernfors
Schwann Cell Precursors from Nerve Innervation is a Cellular Origin of Melanocytes in Skin

Cell, 16 October 2009


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genetic Impact of Endurance Training
Research has found that endurance training changes genetic activity in thousands of genes, giving rise to large number of altered RNA variants.
Tuesday, September 27, 2016
Why Pneumococci Primarily Affects Human
A sugar molecule variant may explain why pneumococcal infections occur more frequently in humans compared to other animals.
Monday, September 05, 2016
A New Method Simplifies Blood Biomarker Discovery And Analysis
Scientists at Karolinska Institutet in collaboration with Estonian Competence Centre on Health Technologies have developed a new gene expression analysis method to widen the usage of blood in biomarker discovery and analysis.
Tuesday, August 16, 2016
Insights into Early Human Embryo Development
Researchers at Karolinska Institutet and the Ludwig Cancer Research in Stockholm have conducted a detailed molecular analysis of the embryo’s first week of development.
Monday, April 11, 2016
Complex Grammar of the Genomic Language
A new study from Karolinska Institutet shows that the ‘grammar’ of the human genetic code is more complex than that of even the most intricately constructed spoken languages in the world.
Thursday, November 12, 2015
New Mechanism Discovered Behind Infant Epilepsy
Scientists at Karolinska Institutet and Karolinska University Hospital have discovered a new explanation for severe early infant epilepsy.
Monday, September 07, 2015
Stem Cells from Nerves Forming Teeth
Findings published in the scientific journal Nature.
Wednesday, July 30, 2014
Different Cell Mechanisms Behind Regenerated Limbs
Scientists at Karolinska Institutet have discovered that two separate species of salamander differ in the way their muscles grow back in lost body parts.
Tuesday, November 26, 2013
New European Vaccine Initiative
Leading organisations have joined forces to rapidly assess and communicate the benefits and risks of vaccines.
Tuesday, November 26, 2013
Synthetic mRNA can Induce Self-Repair and Regeneration of the Infarcted Heart
A team of scientists has instructing injured hearts in mice to heal by expressing a factor that triggers cardiovascular regeneration driven by native heart stem cells.
Monday, September 16, 2013
Technological Breakthrough Paves the Way for Better Drugs
Researchers have developed the first method for directly measuring the extent to which drugs reach their targets in the cell.
Monday, July 08, 2013
Possible Goal for New Tuberculosis-Vaccine Identified
A new study shows for the first time the essential role of the molecule SOCS3 in the control of Tuberculosis.
Monday, July 08, 2013
Trackable Drug-Filled Nanoparticles - a Potential Weapon against Cancer
Tiny particles filled with a drug could be a new tool for treating cancer in the future.
Monday, March 04, 2013
Learning the Alphabet of Controlling Gene Expression
Scientists at Karolinska Institutet have made a large step towards the understanding of how human genes are regulated.
Monday, January 21, 2013
New Hope for Setback-dogged Cancer Treatment
Researchers at Karolinska Institutet announce breakthrough in the study of how IGF-1 receptor-binding antibodies can help those with cancer.
Wednesday, November 28, 2012
Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Researchers Find a Gap in the Brain’s Firewall Against Parkinson’s Disease
Researchers at NIH have found mouse study that identified a key player in the progression of the disorder.
Fat Cells That Amplify Nerve Signals in Response to Cold Also Affect Blood Sugar Metabolism
Researchers at UTSW have found that the protein connexin 43 forms cell-to-cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.
Drug to Treat Alcohol Use Disorder Shows Promise Among Drinkers With High Stress
The findings suggest that potential future studies with drugs targeting vasopressin blockade should focus on populations of people with AUD who also report high levels of stress.
C Dots Show Powerful Tumor Killing Effect
Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer.
Faecal Bacteria Linked to Body Fat
Researchers at King’s College London have found a new link between the diversity of bacteria in human poo – known as the human faecal microbiome - and levels of abdominal body fat.
How Baby’s Genes Influence Birth Weight And Later Life Disease
The large-scale study could help to target new ways of preventing and treating these diseases.
Genes Underlying Dogs’ Social Ability Revealed
The social ability of dogs is affected by genes that also seem to influence human behaviour, according to a new study from Linköping University in Sweden.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!