Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

A Simplified Determination of 2-Ethylhexanoic Acid in Clavulanate

Published: Thursday, October 28, 2010
Last Updated: Thursday, October 28, 2010
Bookmark and Share
Dionex have developed a simplified method for the detection and quantification of 2-ethylhexanoic acid, a potential impurity in potassium clavulanate active pharmaceutical ingredient (API) incorporated during sample purification.

The determination method is outlined in Application Note 262: Determination of 2-Ethylhexanoic Acid Impurity in Clavulanate and reports results for limit of detection/limit of quantification (LOQ/LOQ), linear calibration range, spike recovery, retention time precision, and peak area precision determinations that show this to be an accurate and reproducible technique to determine 2-ethylhexanoic acid in clavulanate below the 0.8% acceptance criteria.

The methodology in Application Note 262 uses a Dionex Reagent-Free™ Ion Chromatography (RFIC™) system and direct injection onto an IonPac® AS11 column without additional sample pretreatment. This approach uses 150-fold lower concentration of the API and eliminates the need for solvent extraction per the current United States Pharmacopeia (USP) monograph, thus consuming less of the API and simplifying sample preparation.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

US EPA to Begin Regulatory Process for Perchlorate in Drinking Water
On 2nd February the EPA announced a final regulatory determination for perchlorate in drinking water. This announcement from Lisa Jackson, Administrator for the US EPA, reversed a preliminary determination in 2008 not to regulate perchlorate.
Wednesday, May 04, 2011
Simple Method for Measuring Sialic Acids in Infant Formula in Half the Time
A new method for the simple determination of sialic acids that are present in infant formula in the pmol range has been announced by Dionex.
Wednesday, December 08, 2010
SPE Method to Recover Low Concentrations of Microcystins in Water
A newly developed method that can fully recover low concentrations (< 1 µg/L) of three microcystins (-RR, -YR, and -LR) when added to water samples has been announced by Dionex.
Thursday, November 18, 2010
FDA Chooses Award Winning Ion Chromatography System from Dionex for Analysis of Biogenic Amines
Dionex is pleased to announce that the United States Food and Drug Administration (FDA) in Irvine, California have purchased the new, award-wining Dionex ICS-5000 (analytical and capillary scale) with Mass Spectrometry system for the analysis of biogenic amines (histamine, putrescine, and cadaverine) in fish samples.
Tuesday, November 16, 2010
Dionex Announces EPA Federal Register Approval of Ion Chromatography for Total Cyanide Analysis
Dionex Corporation have announced that the United States EPA is proposing to add new and revised methods published by EPA, voluntary consensus organizations such as ASTM International, and other commercial entities, for use in water quality monitoring. These changes and additional methods will provide increased flexibility to the regulated community and laboratories in their selection of analytical methods for use in Clean Water Act programs.
Monday, November 08, 2010
Recent Research Demonstrates Determination of Total Phosphorus in Wastewater
Total Phosphorus in water is determined using Caro's Reagent and Ion Chromatography.
Tuesday, October 26, 2010
Dionex ICS-5000 RFIC System Wins Bronze Star at GIT Innovations Award 2010
Introduced at Analytica 2010, the ICS-5000 RFIC system made it through a rigorous selection process and voted as one of the winners.
Friday, April 30, 2010
Dionex Releases their Updated Mass Spectrometry Applications Guide
The update provides 12 new environmental and industrial applications.
Thursday, April 08, 2010
Dionex Acquires Swift Monolithic LC Media Technology
This deal expands and strengthens Dionex' polymer bead-based separation media technology platform for ion chromatography and HPLC.
Thursday, September 01, 2005
Dionex gets new CEO

Monday, July 01, 2002
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Core-Shell Columns in HPLC: Food Analysis Applications
Explore the most recent applications of core-shell columns in food analysis.
Review of the Analysis of Haemoglobin A1c for Diabetes Diagnostics
This paper aims to clarify methods, units, quality requirements, reference and cutoff limits for hemoglobin A1c (HbA1c) and ratio of blood glucose/HbA1c on the basis of the results from Finnish quality control surveys by comparing them to the literature.
Colon Cancer Blocked in Mice
Case Western Reserve University Researchers block common type of colon cancer tumour in mice, laying groundwork for human clinical trial.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Disrupting Tumour-Promotion in Humans
Researchers have modified an existing protein to represses a specific cancer-promoting ‘message’ within cells.
Protein Nanocages Could Improve Drug Design and Delivery
HHMI scientists have designed and built 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
Vaccine Strategy Targets Multiple Influenza Viruses
Scientists have identified vaccine-induced antibodies that can neutralize strains of influenza virus that infect humans.
Connectome Map More Than Doubles Human Cortex’s Known Regions
Researchers at NIH have developed software that automatically detects the “fingerprint” of each of these areas in an individual’s brain scans.
Discovered Through ‘Big Data’ Analysis
Researchers at the SBP have identified over 100 new genetic regions that affect the immune response to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!