The University of Southern California established the first dedicated Epigenome Center in the nation in July 2007, to conduct high throughput epigenomics and leverage. The USC Epigenome Center conducts genome-wide epigenetic analyses and technology development for their cutting-edge epigenomic and population-based genomic research.
The Center was recently awarded funding to participate in The Cancer Genome Atlas (TCGA) consortium to collect epigenomic data from all major human cancers over the next five years, in collaboration with Dr. Steve Baylin at Johns Hopkins University.
Like many other next generation sequencing labs, the Epigenome Center is scrambling to keep up with continually evolving protocols and updates to Illumina’s analysis pipeline software, which have lead to a 15-fold increase in generated sequencing data since the Center ventured into next generation sequencing. The Bioinformatics realized, after receiving its first Genome Analyzer, that they would require a centralized data and lab management informatics system.
This case study details how the Genologics have enabled the USC Epigenome Center to keep pace with both next generation sequencing and rising throughput.