Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Novel Polyadenylation Genome-wide Profiling Achieved using Next Generation Sequencing Software

Published: Monday, January 10, 2011
Last Updated: Monday, January 10, 2011
Bookmark and Share
A paper published in the journal Cell highlighting a novel genome wide profile of polyadenylation events in human and yeast, performed with Direct RNA Sequencing, demonstrated the importance of appropriate bioinformatics software in maximizing the value of the genomic data.

The data analysis used the recently introduced SeqSolve Next Generation Sequencing (NGS) functional bioinformatics analysis software and Direct RNA Sequencing. The discovered novel polyadenylation genomic sites and signals will provide a unique reference resource for the scientific community.
 
The published results demonstrate the crucial importance of appropriate bioinformatics software in maximizing the value of the data produced by high-end last generation high-throughput sequencing instruments. This is important in a market environment, where the cost of sequencing is plummeting, but the revolution is limited by a bottleneck at the level of downstream functional data analysis and interpretation.
 
The SeqSolve analysis software is an independent, multi-organism sequencing solution, performing tertiary level analyzes for biologically relevant results. It features the exclusive Click and GO(R) technology for seamless transcriptome profiling automation and quality control, besides the TIBCO Spotfire(R) platform for scientific data visualization and extended downstream analysis.
 
“The article in Cell follows an article published in Nature in July 2010 about the initial SeqSolve analysis and demonstrates both our commitment to and the value of our SeqSolve software,” said Dr. Michael J. McManus, CEO, Integromics. “Integromics developed the software to perform high-throughput sequencing data analysis and to discover previously unidentified mechanisms, events, signals and correlations in the genomes of human and other organisms.”
 
The Cell article, entitled ‘Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation’ (Vol. 143, Issue 6, p. 1018, http://www.cell.com/abstract/S0092-8674%2810%2901300-0), was co-authored by Dr. Sylvain Foissac from Integromics, SL.; Drs. Bino John, A. Paula Monaghan, Elane Fishilevich and Sang Woo Kim, from the University of Pittsburgh School of Medicine; and Drs. Fatih Ozsolak, Philipp Kapranov and Patrice Milos from Helicos BioSciences Corporation.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Integromics Partners with CITRE and CEIT
Venture attracts EUR 2 million grant for ‘new frontier’ of data interpretation for drug development.
Friday, April 19, 2013
Integromics Invests in the Optimization of Computing Performance for Bioinformatics Applications
Key collaboration with European experts of HPC to bring new big-data computing solutions into genomics.
Friday, March 22, 2013
Integromics Partners with FPGMX to Develop Low-Cost Methods for Clinical Genomics
Venture attracts EUR one million grant for ‘new frontier’ of data interpretation for medical usage.
Tuesday, February 07, 2012
Integromics and Ingenuity Expand their Co-operation with the Integration of a Fourth Integromics Product to Ingenuity’s IPA
Combined solutions to offer bridge between discovery and relevance of genomics and proteomics.
Thursday, April 07, 2011
Integromics and TATAA Biocenter Collaborate to offer Comprehensive qPCR Data Analysis
The TATAA Biocenter is recommending Integromics’ RealTime StatMiner® as a complete solution for qPCR data analysis.
Monday, March 08, 2010
Integromics S.L. Integrates GeneBio’s Phenyx within OmicsHub Proteomics
Geneva Bioinformatics (GeneBio) SA and Integromics S.L. today announced that GeneBio's Phenyx software platform for MS data analysis has been successfully integrated into Integromics’ latest proteomics data analysis and management tool - OmicsHub Proteomics. This integration gives Phenyx and OmicsHub Proteomics users the possibility of combining results from different search engines thereby increasing the accuracy of the protein identification process.
Wednesday, September 23, 2009
Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
COPD Linked to Increased Bacterial Invasion
Persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!