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Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection

Published: Tuesday, January 11, 2011
Last Updated: Tuesday, January 11, 2011
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An Article published in Chromatographia details how researchers at the National Medicines Institute Warsaw and Warsaw Medical University have utilised LC with charged aerosol detection to determine gentamicin sulphate composition in pharmaceutical preparations.

The work reported within this article demonstrates that this novel method was fast, precise, accurate and sensitive and can be used to analyze commercial samples from different manufacturers. This method was shown to provide quality analysis of the substance and pharmaceutical preparations for different QC laboratories.


A new, simple and repeatable liquid chromatography method with charged aerosol detection (LC-CAD) for the determination of gentamicin sulphate composition and related substances has been developed. Gentamicin lacks of chromophores, therefore its determination is quite problematic. Using a universal CAD enables to achieve good separation without sample derivatization. Mass spectrometry was employed to confirm the LC-CAD peak profile. The proposed method was validated and applied for the determination of gentamicin sulphate composition and related substances in pharmaceutical preparations.

The article is published online within the journal, Chromatographia and is free to access.

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