" "
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Whole Genome Sequencing used to Help Inform Cancer Therapy

Published: Wednesday, February 16, 2011
Last Updated: Wednesday, February 16, 2011
Bookmark and Share
Physicians and researchers at Mayo Clinic in Arizona and the Translational Genomics Research Institute (TGen) have successfully completed sequencing both a single patients normal and cancer cells - more than 6 billion DNA chemical bases.

While the whole genomes of several individuals or their cancers have been sequenced in recent years, this is believed to be among the first successful application of whole genome sequencing performed in support of the medical care of a specific cancer patient.

A male patient with pancreatic cancer was the first patient at Mayo Clinic to have whole genome sequencing performed on both his tumor and non-cancerous cells as part of a clinical research project. By comparing the tumor DNA to the patient’s normal DNA, researchers found genetic changes (mutations) that were important in helping inform doctors about how best to plan the patient’s next treatment. This was a case of using a definable genetic change that could be linked to specific treatment, something believed to be a glimpse into the almost certain future of individualizing cancer care.

Mayo Clinic administered all the clinical aspects of the research. TGen performed the genetic sequencing.

While the Mayo-TGen sequencing was done as part of ongoing research, it signals a major step toward implementation of whole genome sequencing to support clinic treatment options.

“This is a demonstration of the clinical utility of whole genome sequencing,” said Keith Stewart, M.B., Dean of Research at Mayo Clinic. “As we do more and more of this, we will move closer and closer to personalized genetic medicine, which means using genetic information to minimize or prevent disease.”

Details of this research, its results and implications for the future, will be included in an upcoming scientific paper.

Cost reductions start to make whole genome sequencing practical

In 2003, after 13 years and nearly $2.7 billion, the government-funded international Human Genome Project deciphered the first entire human genome sequence. Continuing technological advances now allow scientists to evaluate the entire human genome at a fraction of the time and cost.

“No one thought that this would be possible this soon, and the key now is to combine all medical and scientific information together,” said Mitesh J. Borad, M.D., Assistant Professor of Medicine and oncology specialist at Mayo Clinic. “However, we are still very early in the process. A lot of questions will come out of this. But in the long run, this will only help.”

Other sequencing techniques — such as genome-wide association studies — are less expensive tests, but examine only selected portions of DNA. Whole genome sequencing (WGS) looks at the entire genome, giving scientists the most comprehensive view of the potential genetic origins of disease.

“Increasingly we will use information from an individuals DNA sequence to expand from today’s attempts to define disease risk to actual disease management,” said Jeffrey Trent, Ph.D., President and Research Director at TGen and the former Scientific Director of the federal government’s National Human Genome Research Institute. “We recognize our lack of complete knowledge of many of the genetic changes we observe, and how exactly they will align with drugs for treatment.  However, the use of new compounds for some leukemias and gastrointestinal tumors with defined genetic alterations is the prototype example of a genetic change matched to a targeted therapy providing profound clinical benefit.  Our study is one of a handful now underway that is attempting to identify and then match a gene alteration to a targeted agents.”

Uncovering a precise origin of diseases

Performing genomic sequencing on cancerous tumors may provide clinicians with information to treat cancer more precisely, especially for patients who are resistant to traditional treatments. Cancer is a disease often rooted in genetic mutations and can change a person’s DNA. Essentially, WGS distills all the molecular ingredients that make up a person’s genetics so physicians can pinpoint the root cause of a disease. The knowledge gained from this research should allow clinicians to design treatments to address many specific diseases.

“Every step we take in research gets us closer to making this routine for cancer patients,” said Rafael Fonseca, M.D., Deputy Director, Mayo Clinic Cancer Center in Arizona. “If we look in the not too distant future, this is a possibility for every cancer patient.”

At this point, start-up costs for WGS are still significant. Genetic sequencing of tumors requires immense technological and human resources. Once processes are developed and regularly implemented, the long-term costs of sequencing are expected to further drop.

“Whole genome sequencing allows us to dig deeper into the genome than ever before by providing more information and increasing our probability of identifying an ‘Achilles heel’ not previously recognized by more conventional approaches,” said John Carpten, Ph.D., Director of TGen’s Integrated Cancer Genomics Division. “The long-term hope is that doctors will leverage this information to inform decisions about patient care in cancer, and beyond.’’


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Reprogramming Cancer Cells
Researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
Wednesday, August 26, 2015
Overdose of Vitamin D in Teenagers May Lead to Increased Cholesterol Levels
Dosing obese teens with vitamin D shows no benefits for their heart health or diabetes risk, and could have the unintended consequences of increasing cholesterol and fat-storing triglycerides. These are the latest findings in a series of Mayo Clinic studies in childhood obesity.
Tuesday, August 18, 2015
Mayo, Baylor Collaborate
They aim to study genomic links to drug metabolism and other interactions which could be used to provide more tailored patient care.
Friday, May 15, 2015
First Steps in Formation of Pancreatic Cancer Identified
Researchers at Mayo Clinic’s campus in Jacksonville say they have identified first steps in the origin of pancreatic cancer and that their findings suggest preventive strategies to explore.
Tuesday, November 11, 2014
Mayo Clinic, UMMC Expand Relationship
Mayo Clinic and the University of Mississippi Medical Center have signed an agreement to broaden and deepen their collaboration in clinical trials, other medical research and education.
Monday, October 06, 2014
Mayo Clinic, Whole Biome Announce Collaboration
Joint development of microbiome diagnostic testing to focus on women’s health and preterm labor.
Tuesday, May 20, 2014
Virotherapy Shows Promise Against Multiple Myeloma
A Mayo Clinic proof of principle clinical trial, demonstrated that virotherapy, destroying cancer with a virus that infects and kills cancer cells but spares normal tissues, can be effective against multiple myeloma.
Friday, May 16, 2014
Mayo Clinic Researchers Identify Role of Cul4 Molecule in Genome Instability and Cancer
Cul4 helps to deposit DNA-packaging histone proteins onto DNA, an integral step to help compact the genetic code.
Monday, November 11, 2013
Mayo Clinic Launches Biobank in Arizona, Expanding Diversity Research
Mayo Clinic biobank will support studies in obesity, metabolism and diabetes, all areas of special concern in the Latino population.
Tuesday, October 15, 2013
Mayo Florida Receives $5M for Individualized Medicine Clinic
The donation from Florida residents Cecilia and Dan Carmichael will accelerate translation of research to patient care.
Wednesday, August 21, 2013
Mayo Clinic Forms Joint Venture with Cancer Genetics
OncoSpire Genomics will seek to discover and commercialize biomarkers for multiple cancer types.
Thursday, May 23, 2013
Why Does Smallpox Vaccine Shield Some, Not Others? It's in the Genes
How well people are protected by the smallpox vaccine depends on more than the quality of the vaccination: individual genes can alter their response, Mayo Clinic research shows.
Tuesday, April 23, 2013
Saliva Gland Test for Parkinson's Shows Promise
Findings described as a "big step forward" for research and treatment of Parkinson's disease.
Wednesday, January 16, 2013
Mayo Clinic Receives Funding for Gut Function Biomarker Research
The program aims to identify and validate biomarkers that can assess gut function and guide new ways to improve the health and development of children in the developing world.
Friday, December 28, 2012
Men with Fibromyalgia Often Go Undiagnosed, Mayo Clinic Study Suggests
There is not yet a diagnostic test to establish that someone has fibromyalgia, there is no cure and many symptoms can overlap with or get mistaken for other conditions.
Friday, December 21, 2012
Scientific News
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Genetic Cause of Rare Allergy
Institute has identified a genetic mutation responsible for a rare form of inherited hives induced by vibratory urticaria.
Battery Component Found to Harm Key Soil Microorganism
The material at the heart of the lithium ion batteries that power electric vehicles, laptop computers and smartphones has been shown to impair a key soil bacterium, according to new research.
Keeping Tumor Growth at Bay
Engineers at Washington University in St. Louis found a way to keep a cancerous tumor from growing by using nanoparticles of the main ingredient in common antacid tablets.
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Mitochondria Shown to Trigger Cell Ageing
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.
Cancer Cells Kill Off Healthy Neighbours
Cancer cells create space to grow by killing off surrounding healthy cells, according to UK researchers working with fruit flies.
Validating the Accuracy of CRISPR-Cas9
IBS Researchers create multiplex Digenome-seq to find errors in CRISPR-Cas9 processes.
Cancer Drug Target Visualized at Atomic Resolution
New study using cryo-electron microscopy shows how potential drugs could inhibit cancer.
Genetic Mechanism Behind Cancer-Causing Mutations
Researchers at Indiana University has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!