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Knockdown Cell Lines for DNA Repair Studies

Published: Wednesday, February 23, 2011
Last Updated: Wednesday, February 23, 2011
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New range of 20 DNA Repair Knockdown cell lines enables scientists to study the molecular etiology of tumour genomic instability and to exploit it in oncology research.

AMSBIO has announced a new range of highly efficient knockdown cell lines covering the Base Excision DNA Repair pathway.

The new range of 20 DNA Repair Knockdown cell lines was developed to enable scientists to study the molecular etiology of tumour genomic instability and to exploit it in oncology research. The AMSBIO DNA Repair Knockdown cell lines are based upon target-specific LN428 glioblastoma shRNA lentivirus transduced cells that are rigorously qualified and mycoplasma free.

DNA repair pathways maintain the integrity of the genome, reducing the onset of cancer, disease and aging phenotypes. The requirement for DNA repair and genome maintenance in response to radiation and genotoxic chemotherapeutics implicates DNA repair proteins as prime targets for improving response to currently available anti-cancer regimens. AMSBIO's DNA repair knockdown cell lines provide essential tools to address these needs.

All AMSBIO DNA Repair Knockdown Cell Line products are evaluated by RT-PCR and Western Blots in addition functional assays are performed were feasible. The knockdown efficiency of the new DNA Repair Knockdown Cell Lines on target genes, as measured by RT-PCR, is 63-98%.

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