Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Pacific Biomarkers' Dr. Amar A. Sethi Recognized by R&D Directions as One of Nine "Most Notable People in R&D"

Published: Thursday, March 03, 2011
Last Updated: Thursday, March 03, 2011
Bookmark and Share
Vice President of R&D singled out for work in seeking clues to heart-disease risk.

Pacific Biomarkers, Inc., a provider of biomarker laboratory services to the pharmaceutical, biotechnology and diagnostics industries, has announced that Amar A. Sethi, MD, PhD, the Company's Vice President of Research and Development, has been named as one of R&D Directions' "Most Notable People in R&D."

"We are very pleased and proud that Amar has been recognized with this distinguished honor. He has been an extremely valuable member of our team and has been instrumental in advancing our biomarker development programs for cardiovascular disease and kidney injury," said Ron Helm, PBI's Chairman and Chief Executive Officer.

Helm continued, "PBI is committed to scientific and commercial excellence as our fundamental mission to develop novel biomarkers, and Amar's leadership in spearheading our efforts exemplifies this commitment."

"I am sincerely honored to be recognized by R&D Directions," said Dr. Sethi. "I continue to be fortunate to now have so many enriching opportunities in R&D, and I am particularly grateful for helping to leverage my years of experience in biomarker research toward PBI's specific research initiatives."

R&D Directions' selection of the "Most Notable People in R&D" pays tribute to those who have made significant breakthroughs in the discovery and development of drugs that indelibly change the ways in which particular diseases are treated.

Dr. Sethi's entire career has been oriented toward analyzing markers in the human body that indicate the presence of specific ailments. After receiving his PhD in genetic epidemiology at the University of Copenhagen School of Medicine, he undertook postdoctoral research at Copenhagen University Hospital. There he investigated the genetic variation of the liver x-receptor and the beta-2 adrenergic receptor genes and their potential associations with cardiovascular diseases.

Later, as an NIH postdoc, he focused on such topics as the compositional and functional properties of HDL in patients with ischemic heart disease, and the characterization and function of new Apo-AI mimetic peptides potentially to be used as HDL-C raising compounds.

Last year, Dr. Sethi was lead author on a research study published in Clinical Chemistry that identified the potential use of two diagnostic markers for ischemic heart disease. Individuals with ischemic heart disease and either high or low HDL-cholesterol levels were compared with subjects without ischemic heart disease. The study found that pre-beta1 HDL concentrations were twice as high in individuals with ischemic heart disease as compared to those with no heart disease. This was true in both the high and low HDL-cholesterol groups.

The patients with elevated pre-beta1 HDL levels also had low LCAT, an enzyme important for removing excess cholesterol levels. Measuring both pre-beta1 HDL and LCAT, the authors were able to correctly classify subjects with ischemic heart disease in more than 90% of the cases. Thus, pre-beta1 HDL concentrations and LCAT activity levels are potentially useful diagnostic markers for ischemic heart disease.

In addition to his work on cardiovascular disease, Sethi is helping to lead Pacific Biomarkers’ Kidney Injury Biomarker Initiative. It is anticipated that new kidney safety biomarkers will be developed to the point of use in clinical trials and ultimately as a basis of more accurate and powerful IVDs that could replace existing standard tests that are >60 years old. The initiative aims to identify the biological, analytical and clinical qualities of the markers via collaboration with several clients.

To date, the analytical performance for some of the markers has already been characterized, while validation of others is still in progress. A chief goal will be to find the methods and testing platforms that produce superior precision, accuracy, sensitivity and specificity.

The range of potential IVD tests making use of these markers includes one that could assist physicians who need general information about acute kidney injury; a test for use in the emergency room leading up to a kidney transplant; and a test to follow the progress of diabetic patients, a population prone to kidney disease.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Pacific Biomarkers, WuXi PharmaTech Announce Biomarker Collaboration
PBI will provide access to its extensive menu of validated biomarker assays to support WuXi's integrated clinical trial testing services.
Tuesday, March 11, 2014
Pacific Biomarkers Announces New Chief Scientific Officer
Pacific Biomarkers names the company's current Vice President, Research and Development, Amar A. Sethi, MD, PhD, as the new Chief Scientific Officer.
Tuesday, January 03, 2012
Pacific Biomarkers' Dr. Amar A. Sethi Honored by Pharmaceutical Executive Magazine as One of 30 Emerging Pharma Leaders of 2011
Vice president of R&D called "A Pathfinder in Drug Development".
Wednesday, June 29, 2011
Pacific Biomarkers CSO Elizabeth T. Leary Co-Authors Paper in March Issue of Clinical Chemistry
Article explores the contribution of assay methodologies in risk classification for cardiovascular disease.
Wednesday, March 09, 2011
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
Genes That Increase Children's Risk Of Blood Infection Identified
A team led by Oxford University has identified genes that make certain children more susceptible to invasive bacterial infections by performing a large genome-wide association study in African children.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!