Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researchers Mimic Body's Own Healing Potential to Create Personalised Therapies for Inflammation

Published: Wednesday, April 13, 2011
Last Updated: Tuesday, April 12, 2011
Bookmark and Share
Scientists discovered that certain microparticles contained anti-inflammatory lipids, which help terminate inflammation and return the body to its normal balance.

Scientists at Barts and The London School of Medicine and Dentistry and Harvard Medical School, Boston have found a way of mimicking the body's natural mechanism of fighting inflammation. During inflammation cells release very small particles termed 'microparticles' that retain features of their parent cell.

The scientists discovered that certain microparticles were beneficial to health, and that these microparticles contained anti-inflammatory lipids, which help terminate inflammation and return the body to its normal balance.

The discovery, featured online in the current edition of the Journal of Immunology, paves the way for new personalized treatments to target uncontrolled inflammation that need not rely on synthetic biomaterials, therefore reducing potential toxicity.

Inflammation of joints and muscles is implicated in many human diseases including cardiovascular disease, arthritis and temporomandibular disorders and its treatment remains an unmet medical need.

Led by Dr Lucy V Norling (a Foundation Fellow of the Arthritis Research UK), researchers from the William Harvey Research Institute at Barts and The London School of Medicine and Dentistry and Harvard Medical School (laboratory of Professor CN Serhan) investigated the properties of microparticles during inflammatory episodes showing them to contain beneficial lipids (fat molecules) that are precursors for compounds that stimulate the resolution of an inflammatory episode.

The researchers then mimicked this natural communication process to make a new personalized delivery system for anti-inflammatory therapeutics based on natural human microparticles instead of synthetic biomaterials, which bring adverse immunotoxic effects.

The many benefits of these humanized particles, coined 'nano-proresolving medicines' are that they can be loaded with anti-inflammatories (e.g. resolvins or other small molecules) to enhance their protective bioactions.

Dr Norling said: "These results uncover a novel way of targeting anti-inflammatories therapeutics to the site of inflammation using a natural delivery system. I think this new mode of delivery could have application for numerous inflammatory diseases including those of the joint such as arthritis and temporomandibular disorders."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Cancer's Taste for Fat
Researchers discovered signalling pathway for fat burning is disrupted in certain cancers.
Friday, September 16, 2016
Keeping Up with HIV Mutations
Team develops technology to increase the speed of HIV development in mice to model and quickly test vaccination strategies.
Friday, September 09, 2016
Enzyme that Triggers Cell Demise in ALS Identified
Scientists from Harvard have identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis (ALS).
Thursday, August 25, 2016
Misdiagnosis in HCM Tests
Genetic tests for potentially fatal heart anomaly can misdiagnose condition in black Americans.
Thursday, August 18, 2016
Uncovering Constructor Proteins
Scientists have discovered a new bacterial cell wall builder that could be a target for antibiotic development.
Wednesday, August 17, 2016
Discovering the First Farmers
Genetic analyses reveal a collection of highly distinct groups in the Near East and Europe at the dawn of agriculture.
Thursday, July 28, 2016
Doubling Down on Dengue
HMS researchers have discovered two ways a compound blocks dengue virus.
Tuesday, April 26, 2016
Fighting Early Stage Alzheimer's
Mouse study suggests possibility of curbing early synapse loss in Alzheimer’s.
Monday, April 04, 2016
Breaking the Chain
Compound prevents multidrug-resistant fungi from pumping out drugs.
Tuesday, February 23, 2016
Breaking Point
Hotspots for DNA breaks cluster in specific genes in developing neurons.
Wednesday, February 17, 2016
The Spice of Life
Scientists discover important genetic source of human diversity.
Tuesday, February 09, 2016
Cytoskeleton Crew
Findings confirm sugar's role in helping cancers survive by changing cellular architecture.
Tuesday, February 09, 2016
The Power of Three
Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.
Tuesday, February 09, 2016
‘Lifespan Machine’ Probes Cause of Aging
Findings suggest that aging has no single mechanism.
Wednesday, February 03, 2016
Photo Finish
Nanoparticles pair photodynamic and molecular therapies against pancreatic cancer in mice.
Tuesday, January 26, 2016
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Gene Regulation in Brain May Explain Repetitive Behaviors in Rett Syndrome Patients
The research could be a key step in developing treatments to eliminate symptoms that drastically impair the quality of life in Rett patients.
Atmosphere Acidity Minimised to Preindustrial Levels
Sheet ice study shows acidic pollution of the atmosphere has now almost returned to preindustrial levels.
New Therapeutic Target for Crohn’s Disease
A promising new target for drugs that treat IBD has been identified along with a possible biomarker for IBD severity.
Culex Mosquitoes Do Not Transmit Zika
A study of the Culex species mosquito appears to show that the species does not transmit Zika virus.
Uncovering Water Bear Resilience
A protein identified in water bears can protect DNA of human cells from lethal doses of radiation damage.
“Sixth Sense” More Than a Feeling
NIH study of rare genetic disorder reveals importance of touch and body awareness.
Researchers Find Fungus-Fighting Compound
A compound has been identifed that blocks growth of a fungus responsible for lung infections and allergic reactions.
Analysing 10,000 Cells Simultaneously
New techniquethat traps 10,000 cells on a single chip has potential for cancer screening for individuals.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!