" "
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researchers Mimic Body's Own Healing Potential to Create Personalised Therapies for Inflammation

Published: Wednesday, April 13, 2011
Last Updated: Tuesday, April 12, 2011
Bookmark and Share
Scientists discovered that certain microparticles contained anti-inflammatory lipids, which help terminate inflammation and return the body to its normal balance.

Scientists at Barts and The London School of Medicine and Dentistry and Harvard Medical School, Boston have found a way of mimicking the body's natural mechanism of fighting inflammation. During inflammation cells release very small particles termed 'microparticles' that retain features of their parent cell.

The scientists discovered that certain microparticles were beneficial to health, and that these microparticles contained anti-inflammatory lipids, which help terminate inflammation and return the body to its normal balance.

The discovery, featured online in the current edition of the Journal of Immunology, paves the way for new personalized treatments to target uncontrolled inflammation that need not rely on synthetic biomaterials, therefore reducing potential toxicity.

Inflammation of joints and muscles is implicated in many human diseases including cardiovascular disease, arthritis and temporomandibular disorders and its treatment remains an unmet medical need.

Led by Dr Lucy V Norling (a Foundation Fellow of the Arthritis Research UK), researchers from the William Harvey Research Institute at Barts and The London School of Medicine and Dentistry and Harvard Medical School (laboratory of Professor CN Serhan) investigated the properties of microparticles during inflammatory episodes showing them to contain beneficial lipids (fat molecules) that are precursors for compounds that stimulate the resolution of an inflammatory episode.

The researchers then mimicked this natural communication process to make a new personalized delivery system for anti-inflammatory therapeutics based on natural human microparticles instead of synthetic biomaterials, which bring adverse immunotoxic effects.

The many benefits of these humanized particles, coined 'nano-proresolving medicines' are that they can be loaded with anti-inflammatories (e.g. resolvins or other small molecules) to enhance their protective bioactions.

Dr Norling said: "These results uncover a novel way of targeting anti-inflammatories therapeutics to the site of inflammation using a natural delivery system. I think this new mode of delivery could have application for numerous inflammatory diseases including those of the joint such as arthritis and temporomandibular disorders."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

The Spice of Life
Scientists discover important genetic source of human diversity.
Tuesday, February 09, 2016
Cytoskeleton Crew
Findings confirm sugar's role in helping cancers survive by changing cellular architecture.
Tuesday, February 09, 2016
The Power of Three
Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.
Tuesday, February 09, 2016
‘Lifespan Machine’ Probes Cause of Aging
Findings suggest that aging has no single mechanism.
Wednesday, February 03, 2016
Photo Finish
Nanoparticles pair photodynamic and molecular therapies against pancreatic cancer in mice.
Tuesday, January 26, 2016
High-fidelity CRISPR
Improved gene-editing tool has no detectable off-target mutations.
Thursday, January 07, 2016
Stem Cell Memory
Scientists find molecular key that prevents the conversion of adult cells into iPS cells.
Tuesday, January 05, 2016
Hit Parade
Researchers are generating a list of compounds that may lead to a trio of new therapeutics.
Tuesday, December 22, 2015
Stockpiling Proteins
New web-based tool allows researchers to measure protein dynamics in embryogenesis.
Wednesday, December 09, 2015
A Natural History of Neurons
Diverse mutations reveal lineage of brain cells.
Monday, October 05, 2015
The Final Word on STAP
Researchers fail to replicate STAP study; computational analysis reveals genomic inconsistency.
Monday, September 28, 2015
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Tuesday, August 25, 2015
Combo Tool
Joining molecular components expands ability to manipulate genes in specific cell types.
Tuesday, August 25, 2015
The Autism-GI Link
Inflammatory bowel disease found more prevalent in ASD patients.
Tuesday, August 18, 2015
Facebook for the Proteome
Researchers have developed a network for describing protein-protein interactions that can then be used to examine protein interactions that may have biological or clinical significance.
Friday, July 17, 2015
Scientific News
Criminal Justice Alcohol Program Linked to Decreased Mortality
Institute has announced that in the criminal justice alcohol program deaths dropped by 4.2 percent over six years.
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
Improving Regenerative Medicine
Lab-created stem cells may lack key characteristics, UCLA research finds.
Tick Genome Reveals Secrets of a Successful Bloodsucker
NIH has announced that decipher the genome of the blacklegged tick which could lead to new tick control methods.
"Dark Side" of the Transcriptome
New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.
Individuals' Medical Histories Predicted by their Noncoding Genomes
Researchers have found that analyzing mutations in regions of the genome that control genes can predict medical conditions such as hypertension, narcolepsy and heart problems.
'Molecular Movie' Opens Door to New Cancer Treatments
An international team of scientists led by the University of Liverpool has produced a 'structural movie' revealing the step-by-step creation of an important naturally occurring chemical in the body that plays a role in some cancers.
New Source of Mutations in Cancer
Recently, a new mutation signature found in cancer cells was suspected to have been created by a family of enzymes found in human cells called the APOBEC3 family.
Advancing Synthetic Biology
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.
Madison Researchers Begin Work on Zika Virus
Work will start with basic questions about Zika virus infection.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!