Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Exciting New Leads in the Fight against Malaria

Published: Monday, June 27, 2011
Last Updated: Monday, June 27, 2011
Bookmark and Share
Researchers from the University of Liverpool and the London and Liverpool Schools of Tropical Medicine have developed a new series of tetraoxane analogues and screened them for their in vitro and in vivo antimalarial activity.

Malaria is a parasitic disease caused by Plasmodium spp. which still ravages many parts of the world, responsible for killing an estimated 781,000 people each year according to the World Health Organisation’s 2010 World Malaria Report. Treatment is frequently associated with the development of resistance and so new drug leads are always needed.

All of the compounds synthesized in this study showed remarkable in vitro activity in the low nanomolar range (0.2–3.7 nM) and several demonstrated promising oral activity in the P. berghei ANKA mouse model of malaria.

A preliminary study suggests that members of this series have improved metabolic stability compared with the parent compound RKA182 and these data coupled with the excellent activity profiles, low ClogP and high aqueous solubilities (e.g. >40mg/ml) make this series an exciting development in the struggle against malaria.

Reproduced by permission from The Royal Society of Chemistry from MedChemComm Blog at http://blogs.rsc.org/md/


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Centrifuge-on-a-Chip and Next-Generation Integrated Microfluidics
A microfluidic chip that can mimic the functions of a centrifuge without moving parts or external forces has been designed by Dino Di Carlo and colleagues from the University of California, Los Angeles.
Wednesday, August 17, 2011
Aminoazines and their Affinity for Graphite
In this CrystEngComm Hot article James D. Wuest and co-workers from the University of Montréal, Canada, look at crystalline amino-substituted azines.
Monday, June 27, 2011
Strategies in Organocatalysts Immobilisation
This review summarizes the successful application of non-covalent interactions, such as acid–base interaction, ion–pair interaction, hydrophobic interaction and so on, in assembling recoverable and reusable organocatalysts.
Friday, June 17, 2011
Nanorods Make a Stand
Utilizing an interesting seed-mediated approach ZnO nanorods were helped to “stand” vertically on microsubstrates.
Monday, June 13, 2011
Drugs that go beyond the rule of five – or do they?
In this HOT paper, published in MedChemComm, researchers from Pfizer explore the influence of intramolecular hydrogen bonding on the membrane permeability and bioavailability of these drugs.
Friday, June 03, 2011
The Importance of Green Chemistry in Process Research and Development
Concern for our planet and its well being is forcing chemists to think about greener, more sustainable processes to make the things we need and want, such as new technologies, fuels and drugs.
Wednesday, June 01, 2011
Assembling Isoniazid
This paper, published in the journal CrystEngComm, describes how researchers have modified the hydrogen bonding in isonicotinic acid hydrazide (isoniazid) in order to control the self-assembly process.
Monday, May 23, 2011
ESR Spectroscopy as a tool to Investigate the Properties of Self-Assembled Monolayers Protecting Gold Nanoparticles
An Article published in Nanoscale details how researchers at the University of Bologna and the University of Trieste have used Electron spin resonance (ESR) spectroscopy technique to study the properties of metal nanoparticles.
Thursday, November 25, 2010
RSC Holds 5th Conference on High Throughput Medicinal Chemistry
The conference will explore technology-enabled drug discovery and new synthetic technologies, focusing medicinal chemistry on 12th May 2009 in Cheshire, UK.
Monday, May 04, 2009
Scientific News
RNAi Screening Trends
Understand current trends and learn which application areas are expected to gain in popularity over the next few years.
New Weapon in the Fight Against Blood Cancer
This strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
TOPLESS Plants Provide Clues to Human Molecular Interactions
Scientists at Van Andel Research Institute have revealed an important molecular mechanism in plants that has significant similarities to certain signaling mechanisms in humans, which are closely linked to early embryonic development and to diseases such as cancer.
Toxin from Salmonid Fish has Potential to Treat Cancer
Researchers from the University of Freiburg decode molecular mechanism of fish pathogen.
Study Finds Non-Genetic Cancer Mechanism
Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.
Scientists Create CRISPR/Cas9 Knock-In Mutations in Human T Cells
In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
Researchers Find U.S. Breast Milk is Glyphosate Free
Washington State University scientists have found that glyphosate, the main ingredient in the herbicide Roundup, does not accumulate in mother’s breast milk.
Peering into the Vapors
Research suggests that e-cigarettes are much less harmful than previous studies have indicated.
New Technique for Mining Health-conferring Soy Compounds
A new procedure devised by U.S. Department of Agriculture (USDA) scientists to extract lunasin from soybean seeds could expedite further studies of this peptide for its cancer-fighting potential and other health benefits.
Long-sought Discovery Fills in Missing Details of Cell 'Switchboard'
A biomedical breakthrough reveals never-before-seen details of the human body’s cellular switchboard that regulates sensory and hormonal responses.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!