Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Exciting New Leads in the Fight against Malaria

Published: Monday, June 27, 2011
Last Updated: Monday, June 27, 2011
Bookmark and Share
Researchers from the University of Liverpool and the London and Liverpool Schools of Tropical Medicine have developed a new series of tetraoxane analogues and screened them for their in vitro and in vivo antimalarial activity.

Malaria is a parasitic disease caused by Plasmodium spp. which still ravages many parts of the world, responsible for killing an estimated 781,000 people each year according to the World Health Organisation’s 2010 World Malaria Report. Treatment is frequently associated with the development of resistance and so new drug leads are always needed.

All of the compounds synthesized in this study showed remarkable in vitro activity in the low nanomolar range (0.2–3.7 nM) and several demonstrated promising oral activity in the P. berghei ANKA mouse model of malaria.

A preliminary study suggests that members of this series have improved metabolic stability compared with the parent compound RKA182 and these data coupled with the excellent activity profiles, low ClogP and high aqueous solubilities (e.g. >40mg/ml) make this series an exciting development in the struggle against malaria.

Reproduced by permission from The Royal Society of Chemistry from MedChemComm Blog at http://blogs.rsc.org/md/


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Friday, May 27, 2016
Centrifuge-on-a-Chip and Next-Generation Integrated Microfluidics
A microfluidic chip that can mimic the functions of a centrifuge without moving parts or external forces has been designed by Dino Di Carlo and colleagues from the University of California, Los Angeles.
Wednesday, August 17, 2011
Aminoazines and their Affinity for Graphite
In this CrystEngComm Hot article James D. Wuest and co-workers from the University of Montréal, Canada, look at crystalline amino-substituted azines.
Monday, June 27, 2011
Strategies in Organocatalysts Immobilisation
This review summarizes the successful application of non-covalent interactions, such as acid–base interaction, ion–pair interaction, hydrophobic interaction and so on, in assembling recoverable and reusable organocatalysts.
Friday, June 17, 2011
Nanorods Make a Stand
Utilizing an interesting seed-mediated approach ZnO nanorods were helped to “stand” vertically on microsubstrates.
Monday, June 13, 2011
Drugs that go beyond the rule of five – or do they?
In this HOT paper, published in MedChemComm, researchers from Pfizer explore the influence of intramolecular hydrogen bonding on the membrane permeability and bioavailability of these drugs.
Friday, June 03, 2011
The Importance of Green Chemistry in Process Research and Development
Concern for our planet and its well being is forcing chemists to think about greener, more sustainable processes to make the things we need and want, such as new technologies, fuels and drugs.
Wednesday, June 01, 2011
Assembling Isoniazid
This paper, published in the journal CrystEngComm, describes how researchers have modified the hydrogen bonding in isonicotinic acid hydrazide (isoniazid) in order to control the self-assembly process.
Monday, May 23, 2011
ESR Spectroscopy as a tool to Investigate the Properties of Self-Assembled Monolayers Protecting Gold Nanoparticles
An Article published in Nanoscale details how researchers at the University of Bologna and the University of Trieste have used Electron spin resonance (ESR) spectroscopy technique to study the properties of metal nanoparticles.
Thursday, November 25, 2010
RSC Holds 5th Conference on High Throughput Medicinal Chemistry
The conference will explore technology-enabled drug discovery and new synthetic technologies, focusing medicinal chemistry on 12th May 2009 in Cheshire, UK.
Monday, May 04, 2009
Scientific News
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Study Identifies How Brain Connects Memories Across Time
UCLA Neuroscientists have boost ability of aging brain to recapture links between related memories.
3-D Atomic Structure of Cholesterol Transporter
Researchers at UTSW have determined the 3-D atomic structure of a human sterol transporter that helps maintain cholesterol balance.
First Large-Scale Proteogenomic Study of Breast Cancer
The study offers understanding of potential therapeutic targets.
Can We Break the Link Between Obesity and Diabetes?
Columbia University researchers identify a key molecule involved in the development of type 2 diabetes.
Fungi – A Promising Source Of Chemical Diversity
Moulds and plants share similar ways in alkaloid biosynthesis .
How Prions Kill Neurons: New Culture System Shows Early Toxicity to Dendritic Spines
Boston University researchers have developed a cell culture system to study prions.
Great Migration and African-American Genomic Diversity
Study examines genetic data to analyze regional differences in ancestry.
Faster, More Efficient CRISPR Editing
UC Berkeley scientists have developed a quicker and more efficient method to alter the genes of mice with CRISPR-Cas9, simplifying a procedure growing in popularity because of the ease of using the new gene-editing tool.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!