Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Genetic Variant Linked to Development of Liver Cancer in Hepatitis C Virus Carriers

Published: Monday, July 04, 2011
Last Updated: Monday, July 04, 2011
Bookmark and Share
The research group conduct a genome-wide study to identify risk factors connecting HVC and HCC.

A genome-wide study by researchers at the RIKEN Center for Genomic Medicine, Hiroshima University Hospital and Sapporo-Kosei General Hospital has identified a genetic variant associated with the development of liver cancer in chronic hepatitis C virus carriers.

The findings are based on a study of 3,312 Japanese individuals and appear in the journal Nature Genetics.

Hepatocellular carcinoma (HCC), the most common type of liver cancer, is the third leading cancer-related cause of death and the seventh most common form of cancer worldwide.

The hepatitis C virus (HVC) is the main risk factor for HCC in many western countries and in Japan, where of the more than 30,000 deaths each year from HCC, 70% involve HVC.

To identify risk factors connecting HVC and HCC, the research group conducted a genome-wide study on a group of 3,312 Japanese individuals carrying the hepatitis C virus.

Analyzing a total of 467,538 genetic markers (called single nucleotide polymorphisms or SNPs) in a group of 212 HCV carriers with HCC and 765 HCV carriers without HCC, the group uncovered one SNP associated with HCC risk, located on a gene called DEPDC5.

The association was confirmed in an independent replication study on a population of 2335 HVC carriers, 710 with HCC and 1625 without HCC.

The significance of the findings was further highlighted when the researchers adjusted their results for gender, age and platelet count, revealing that among Japanese individuals with chronic HVC infection, the DEPDC5 SNP roughly doubles the odds of developing HCC.

While deepening our understanding of the mechanisms triggering HCC, the discovery of the DEPDC5 SNP locus also provides a valuable target for new therapy techniques, promising progress in the ongoing battle to overcome one of the world's most deadly cancers.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New ACE-inhibiting Molecule Found in the Asparagus
Scientists have determined that sulfur-containing compounds in plants can inhibit ACE.
Saturday, August 22, 2015
The Genetic Roots of Adolescent Scoliosis
Scientists at the RIKEN Center for Integrative Medical Sciences in collaboration with Keio University in Japan have discovered a gene that is linked to susceptibility of Scoliosis.
Thursday, July 30, 2015
Ensuring Food Safety Using Space Technology
New device can detect cesium isotopes in food samples.
Monday, March 09, 2015
Growing Functioning Brain Tissue In 3D
RIKEN researchers have induced human embryonic stem cells to self-organize into a 3D cerebellum like structure.
Monday, February 02, 2015
Insights Into A Rare Genetic Disease
Study shows mutation in NGLY1 gene is linked to a genetic disorder with severe consequences.
Tuesday, January 20, 2015
Predicting Antibiotic Resistance
A common set of features appear to be responsible for the development of resistance to several types of antibiotics.
Friday, December 19, 2014
A Greasy Way to Take Better Protein Snapshots
Researchers used a newly developed grease to suspend small crystals of lysozyme, glucose isomerase, thaumatin, and fatty acid-binding protein type-3.
Wednesday, November 12, 2014
Stress Turns Ordinary Cells Pluripotent
Researchers demonstrate that ordinary somatic cells from newborn mice can be stripped of their differentiation memory, reverting to a state of pluripotency.
Thursday, January 30, 2014
New Fluorescent Protein from Eel Revolutionizes Key Clinical Assay
Unagi, the sea-going Japanese freshwater eel, harbors a fluorescent protein that could serve as the basis for a revolutionary new clinical test.
Friday, June 21, 2013
Gene Identified Responsible for Disorders of Bones and Connective Tissue
Researchers have identified a gene that when mutated is responsible for a spectrum of disorder.
Monday, May 13, 2013
Japanese Team Creates Cancer-Specific Killer T Cells from iPS Cells
Researchers have succeeded for the first time in creating cancer-specific, immune system cells called killer T lymphocytes, from induced pluripotent stem cells (iPS cells).
Wednesday, January 09, 2013
New Metal Hydride Clusters Provide Insights into Hydrogen Storage
The study sheds light on a class of heterometallic molecular structures whose unique features point the way to breakthroughs in the development of lightweight fuel cell technology.
Thursday, September 22, 2011
RIKEN: Genome-wide Study Reveals 3 New Susceptibility Loci for Adult Asthma in Japanese Population
The findings appear in Nature Genetics and derive from a genome-wide study of 4836 Japanese individuals.
Monday, August 01, 2011
Overlooked Peptide Reveals Clues to Causes of Alzheimer's Disease
Highly aggregative and neurotoxic amyloid peptide A-ß-43 points the way to new approaches for AD diagnosis and treatment.
Monday, July 04, 2011
RIKEN: Mechanism for Stress-induced Epigenetic Inheritance Uncovered in New Study
Results highlight the role of the transcription factor dATF-2 in chromatin assembly, marking a major advance in understanding of non-Mendelian inheritance.
Friday, June 24, 2011
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
Revolutionary Technologies Developed to Improve Outcomes for Lung Cancer Patients
Breath test to detect lung cancer brings oxygen directly to the wound.
NIH Supports New Studies to Find Alzheimer’s Biomarkers in Down Syndrome
Initiative will track dementia onset, progress in Down syndrome volunteers.
Dementia Linked to Deficient DNA Repair
Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer’s disease.
Using Drug-Susceptible Parasites to Fight Drug Resistance
Researchers at the University of Georgia have developed a model for evaluating a potential new strategy in the fight against drug-resistant diseases.
Boosting Breast Cancer Treatment
To more efficiently treat breast cancer, scientists have been researching molecules that selectively bind to cancer cells and deliver a substance that can kill the tumor cells, for several years.
New Gene Map Reveals Cancer’s Achilles’ Heel
Team of researchers switches off almost 18,000 genes
New Discovery Sheds Light on Disease Risk
Gaps between genes interact to influence the risk of acquiring disease.
How Cells ‘Climb’ to Build Fruit Fly Tracheas
Mipp1 protein helps cells sprout “fingers” for gripping.
Research Finding Could Lead to Targeted Therapies for IBD
Findings published online in Cell Reports.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos