Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Landmark Publication Reports Potential of Exosomes as Biomarkers for Early Disease Detection

Published: Thursday, July 07, 2011
Last Updated: Thursday, July 07, 2011
Bookmark and Share
NanoSight reports the new publication in one of the most cited peer reviewed journals in nanoscience and nanotechnology, NanoMedicine.

The rapidly growing field of exosomes and microvesicles is highlighted in a new paper in NanoMedicine. Titled “Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis,” it has been authored by a team led by Professors Ian Sargent and Paul Harrison from the Nuffield Department of Obstetrics & Gynaecology, Oxford University.

Cellular microvesicles and exosomes (nanovesicles) are involved in many disease processes and have been shown to have major potential for use as biomarkers. However, developments in this area have been constrained by limitations in the technology available for their measurement. This ground-breaking paper reports on the use of fluorescence nanoparticle tracking analysis (NTA) to rapidly size and phenotype cellular vesicles. In the NTA system, manufactured by NanoSight (Amesbury, UK), vesicles are visualized by light scattering using a light microscope. A video is recorded and then the NTA software tracks the Brownian motion of the individual vesicles calculating their size and total concentration. Using human placental vesicles and plasma, the team has demonstrated that NTA can measure cellular vesicles as small as ∼50 nm which is far more sensitive than conventional flow cytometry (lower limit ∼300 nm). By combining NTA with fluorescence measurement, it has been shown that vesicles can be labeled with specific antibody-conjugated quantum dots, allowing their phenotype to be determined.

Comprehensive funding for the work was provided by a Wellcome Trust Technology Development, a Wellcome Trust Programme Grant and by the Oxford Partnership Comprehensive Biomedical Research Centre with support from the Department of Health's NIHR Biomedical Research Centres funding scheme.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

The Jagiellonian University Uses NTA to Characterize Catalytic Nanoparticles
NTA used in the Faculty of Chemistry for the characterization of catalytic materials in environmental applications.
Thursday, July 11, 2013
The Institute of Water Resources & Water Supply Implements NTA to Characterize Colloids in Water
Professor Mathias Ernst has adopted the use of NTA technique to provide new insights into water quality.
Wednesday, June 26, 2013
Caltech Uses NTA to Characterize New Therapeutic Nanoparticles
Caltech to study nanoparticle-based therapeutics for the treatment of dementia, Parkinson's and Alzheimer's diseases.
Wednesday, May 01, 2013
Method Development to Estimate the Purity of Vesicle Preparations
Nanoparticle tracking analysis is used to estimate the purity of vesicle preparations at the Cardiff University School of Medicine.
Thursday, February 28, 2013
Polymer Nanoparticles Used as Drug Carriers Characterized Using Nanoparticle Tracking Analysis
NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is used to help with the characterization of polymeric nanoparticles synthesized as drug carrier systems.
Tuesday, February 12, 2013
NanoSight Announce New Appointment
Leading UK scientist, Dr Andrew Shuttleworth, joins NanoSight board as Director of Diagnostic Sciences.
Tuesday, June 26, 2012
NanoSight to Receive Queen's Award for Enterprise
Company announced it has been selected to receive the Queen's Award for Enterprise in the category for International Trade 2012.
Wednesday, May 02, 2012
The EU Definition of Nanomaterials – Getting what you wished for?
NanoSight’s Jeremy Warren, CEO, offers the latest news and views on the EU definition on nanomaterials.
Tuesday, May 01, 2012
Duke University Uses NTA to Characterize "Nanoconstructs" for Biomedical Applications
NTA to characterize metal nanoparticle construct materials for use in biosensing, imaging and cancer therapy.
Friday, April 20, 2012
“Nanomaterials” Defined by European Commission
Watchers of European legislation will recognise this as a watershed and a major move which will have consequence outside Europe.
Thursday, December 15, 2011
NanoSight wins Technology World's 2011 Business Innovation Award
The technology manufacturers are winners of this year's Technology World's 2011 Business Innovation Award in the category of Energy & Environment after receiving a record number of entries surrounding their optical detection and real time analysis of sub-micron particles.
Tuesday, December 06, 2011
NanoSight Recognized as the UK's Fastest Growing Biotech Company
Company has been ranked Fast 50 in the Deloitte 2011 UK technology ranking.
Thursday, November 17, 2011
NanoSight Latest Interactive Webinar: September 22nd Subject: Exosome Characterization by Nanoparticle Analysis
Latest webinar aimed at those with a similar interest in the detection and speciation of exosomes and micro-vesicles.
Friday, September 09, 2011
NanoSight announces interactive webinar on January 27th on Exosome Characterization by Nanoparticle Tracking Analysis
NanoSight, world-leading manufacturers of unique nanoparticle characterization technology, will host an interactive webinar on the subject of exosome characterization by Nanoparticle Tracking Analysis.
Thursday, January 20, 2011
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
Investigating the Vape
Expert independent review concludes that e-cigarettes have potential to help smokers quit.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Researchers Discover Synthesis of a New Nanomaterial
Interdisciplinary team creates biocomposite for first time using physiological conditions.
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!