Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Centrifuge-on-a-Chip and Next-Generation Integrated Microfluidics

Published: Wednesday, August 17, 2011
Last Updated: Wednesday, August 17, 2011
Bookmark and Share
A microfluidic chip that can mimic the functions of a centrifuge without moving parts or external forces has been designed by Dino Di Carlo and colleagues from the University of California, Los Angeles.

Using fluid vortices to trap cells, the Centrifuge-on-a-Chip has been demonstrated to be effective in enriching rare cells from heterogeneous solutions and for performing labelling assays on-chip.

The full article, Automated cellular sample preparation using a Centrifuge-on-a-Chip, is published in the RSC journal Lab on a Chip

The standard centrifuge is a laboratory instrument widely used by biologists and medical technicians for preparing cell samples. Efforts to automate the operations of concentration, cell separation, and solution exchange that a centrifuge performs in a simpler and smaller platform have had limited success. Here, we present a microfluidic chip that replicates the functions of a centrifuge without moving parts or external forces. The device operates using a purely fluid dynamic phenomenon in which cells selectively enter and are maintained in microscale vortices. Continuous and sequential operation allows enrichment of cancer cells from spiked blood samples at the mL min−1 scale, followed by fluorescent labeling of intra- and extra-cellular antigens on the cells without the need for manual pipetting and washing steps. A versatile centrifuge-analogue may open opportunities in automated, low-cost and high-throughput sample preparation as an alternative to the standard benchtop centrifuge in standardized clinical diagnostics or resource poor settings.

Reproduced by permission from The Royal Society of Chemistry from Lab on a Chip Blog at

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Aminoazines and their Affinity for Graphite
In this CrystEngComm Hot article James D. Wuest and co-workers from the University of Montréal, Canada, look at crystalline amino-substituted azines.
Monday, June 27, 2011
Exciting New Leads in the Fight against Malaria
Researchers from the University of Liverpool and the London and Liverpool Schools of Tropical Medicine have developed a new series of tetraoxane analogues and screened them for their in vitro and in vivo antimalarial activity.
Monday, June 27, 2011
Strategies in Organocatalysts Immobilisation
This review summarizes the successful application of non-covalent interactions, such as acid–base interaction, ion–pair interaction, hydrophobic interaction and so on, in assembling recoverable and reusable organocatalysts.
Friday, June 17, 2011
Nanorods Make a Stand
Utilizing an interesting seed-mediated approach ZnO nanorods were helped to “stand” vertically on microsubstrates.
Monday, June 13, 2011
Drugs that go beyond the rule of five – or do they?
In this HOT paper, published in MedChemComm, researchers from Pfizer explore the influence of intramolecular hydrogen bonding on the membrane permeability and bioavailability of these drugs.
Friday, June 03, 2011
The Importance of Green Chemistry in Process Research and Development
Concern for our planet and its well being is forcing chemists to think about greener, more sustainable processes to make the things we need and want, such as new technologies, fuels and drugs.
Wednesday, June 01, 2011
Assembling Isoniazid
This paper, published in the journal CrystEngComm, describes how researchers have modified the hydrogen bonding in isonicotinic acid hydrazide (isoniazid) in order to control the self-assembly process.
Monday, May 23, 2011
ESR Spectroscopy as a tool to Investigate the Properties of Self-Assembled Monolayers Protecting Gold Nanoparticles
An Article published in Nanoscale details how researchers at the University of Bologna and the University of Trieste have used Electron spin resonance (ESR) spectroscopy technique to study the properties of metal nanoparticles.
Thursday, November 25, 2010
RSC Holds 5th Conference on High Throughput Medicinal Chemistry
The conference will explore technology-enabled drug discovery and new synthetic technologies, focusing medicinal chemistry on 12th May 2009 in Cheshire, UK.
Monday, May 04, 2009
Scientific News
13 Ways to Stop an Unseen Force from Disrupting Weighing
Download a free Mettler Toledo paper to discover how to halt static’s negative effects before the next weigh-in.
Flinders Ig Nobel Winner Cracks Global Anaesthetic
One of the world’s most in-demand anaesthetics can now be produced on the spot, thanks to the thermos-flask sized device that recently won Flinders University inventor Professor Colin Raston an Ig Nobel prize.
Resurrected Proteins Double Their Natural Activity
Researchers demonstrate method for reviving denatured proteins.
Genes That Protect African Children From Developing Malaria Identified
Variations in DNA at a specific location on the genome that protect African children from developing severe malaria, in some cases nearly halving a child’s chance of developing the life-threatening disease, have been identified in the largest genetic association study of malaria to date.
Messing With The Monsoon
Manmade aerosols can alter rainfall in the world’s most populous region.
Potential Target for Treatment of Autism
Grant of $2.4 million will support further research.
Scientists Decode Structure at Root of Muscular Disease
Researchers at Rice University and Baylor College of Medicine have unlocked the structural details of a protein seen as key to treating a neuromuscular disease.
Sniffing Out Cancer
Scientists have been exploring new ways to “smell” signs of cancer by analyzing what’s in patients’ breath.
New Test Detects All Viruses
A new test detects virtually any virus that infects people and animals, according to research at Washington University School of Medicine in St. Louis, where the technology was developed.
Inroads Against Leukemia
Potential for halting disease in molecule isolated from sea sponges.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos