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Centrifuge-on-a-Chip and Next-Generation Integrated Microfluidics

Published: Wednesday, August 17, 2011
Last Updated: Wednesday, August 17, 2011
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A microfluidic chip that can mimic the functions of a centrifuge without moving parts or external forces has been designed by Dino Di Carlo and colleagues from the University of California, Los Angeles.

Using fluid vortices to trap cells, the Centrifuge-on-a-Chip has been demonstrated to be effective in enriching rare cells from heterogeneous solutions and for performing labelling assays on-chip.

The full article, Automated cellular sample preparation using a Centrifuge-on-a-Chip, is published in the RSC journal Lab on a Chip

Abstract
The standard centrifuge is a laboratory instrument widely used by biologists and medical technicians for preparing cell samples. Efforts to automate the operations of concentration, cell separation, and solution exchange that a centrifuge performs in a simpler and smaller platform have had limited success. Here, we present a microfluidic chip that replicates the functions of a centrifuge without moving parts or external forces. The device operates using a purely fluid dynamic phenomenon in which cells selectively enter and are maintained in microscale vortices. Continuous and sequential operation allows enrichment of cancer cells from spiked blood samples at the mL min−1 scale, followed by fluorescent labeling of intra- and extra-cellular antigens on the cells without the need for manual pipetting and washing steps. A versatile centrifuge-analogue may open opportunities in automated, low-cost and high-throughput sample preparation as an alternative to the standard benchtop centrifuge in standardized clinical diagnostics or resource poor settings.

Reproduced by permission from The Royal Society of Chemistry from Lab on a Chip Blog at http://blogs.rsc.org/lc/


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