Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Affymetrix Releases Axiom Genome-Wide Pan-African Array

Published: Friday, October 21, 2011
Last Updated: Friday, October 21, 2011
Bookmark and Share
The highest genomic coverage of African and African American genomes for disease association studies.

Affymetrix®, Inc. has announced at the ICHG/ASHG annual conference in Montreal, the worldwide launch of the Axiom® Genome-Wide Pan-African Array, the first commercial product to maximize genomic coverage of both common and rare alleles in populations of African ancestry, including West African, East African, and African American.

The Axiom Solution is the only microarray family of products to provide a complete set of population-optimized arrays for all three HapMap populations: Western European (CEU), East Asian (ASI), and Yoruba (YRI).

Each array is strategically designed to address the unique haplotype structure of these populations to ensure high genomic coverage and statistical power.

“We are currently using the Axiom Pan-African Array for prostate cancer, sickle-cell disease, and drug response research. With greater access to rare variants and increased coverage, I hope to gain better insights into new disease mechanisms.”

“The poor genomic coverage of currently available commercial arrays in African populations has significantly impacted our ability to understand the genetic factors that underlie the increased risk of African Americans for diseases such as cancer (prostate, breast, and colon) and cardiovascular and pulmonary disorders,” said Dr. Rick Kittles, Associate Professor of Medicine and Director of the Institute of Human Genetics at the University of Illinois at Chicago.

Dr. Kittles continued, “We are currently using the Axiom Pan-African Array for prostate cancer, sickle-cell disease, and drug response research. With greater access to rare variants and increased coverage, I hope to gain better insights into new disease mechanisms.”

“The marked improvement in genomic coverage of the Axiom Array is of enormous utility in our attempts to link genetic information and the delivery of personalized medicine,” said Dr. Joe G.N. Garcia, Earl M. Bane Professor of Medicine and Vice President for Health Affairs at the University of Illinois.

Dr. Garcia continued, “We anticipate that information derived from the discovery of important variants which modify risk, modulate responses to therapy, and drive the severity of disease in susceptible populations will be rapidly utilized within the University of Illinois Hospital and Health Sciences System to reduce health disparities.

Until now, studies of African American and African populations have been underrepresented in disease association studies because commercially available arrays of these populations were not optimized for the complex haplotype patterns of African genomes.

The Axiom Pan-African Array offers ~ 90 percent coverage of YRI alleles with minor allele frequency (MAF) ≥2.0 percent. In addition, it has been extensively validated in four African populations from the HapMap collection, including the Luhya from western Kenya (LWK), Maasai from eastern Kenya (MWK), Yoruba from Ibadan, Nigeria, and the African Ancestry in the Southwest USA (ASW).

In all cases, the Axiom Pan-African Array offers an incremental increase of 15-20 percent genomic coverage compared to other commercial arrays.

“African populations have a greater number of smaller haplotype blocks and singletons than European populations and thus require a more sophisticated array design strategy to achieve genomic coverage comparable to levels provided for European populations,” said Andy Last, Executive Vice President and Chief Commercial Officer at Affymetrix.

Last continued, “With the Axiom platform we have an unmatched capability to deliver population-optimized genotyping arrays to ensure that clinical researchers have specialized and cost effective tools to better investigate genetic susceptibility and health disparities in understudied populations.”

The Axiom Pan-African Array was designed by leveraging over 11 million common and rare genomic markers within the Axiom Genomic Database, the industry's largest supply of validated genomic markers.

The array contains more than 2.2 million informative markers that are proven to be heterozygous in the African genome, thus maximizing the analysis of each sample.

Compared to competing arrays with a similar number of markers, it has the highest coverage of variants in important biological categories such as the National Human Genome Research Institute (NHGRI), Catalog of Published Genome-Wide Association Studies, Sanger Cancer Genome Census genes, Major Histocompatibilty Complex (MHC) genes, cardiovascular genes, and immune and inflammation pathway genes. The array also offers coverage across chromosomes X and Y, the mitochondrial genome, and drug metabolism genes.

The complete Axiom Genotyping Solution consists of Axiom Genome-Wide Pan-African Array Plates, the new Axiom 2.0 Reagent Kits, and the new Genotyping Console 4.1 for automated allele calling and quality control.

The Axiom Array Plates are used on the automated target preparation station and GeneTitan® Instrument for hands-free processing.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Affymetrix and Athletigen Partner
Partnership agreement to advance genetics in human athletic performance.
Thursday, October 29, 2015
Affymetrix and Luminex Announce Distribution Agreement
Agreement for multiplexed assay instrument platform.
Friday, October 16, 2015
Green Super Rice Project Selects Affymetrix Genotyping Platform for Developing New Rice Varieties
The Green Super Rice (GSR) project includes building a highly efficient genotyping platform for the large-scale molecular breeding activities within the international rice research community.
Tuesday, September 22, 2015
Affymetrix, BioRealm, RUCDR Ally
Affymetrix, BioRealm, and RUCDR Infinite Biologics today announced a strategic alliance to genotype the National Institute of Drug Abuse biorepository.
Wednesday, July 08, 2015
Affymetrix Acquires Assets of Eureka Genomics
Aquisition will enable provision of high throughput and economical crop and animal genotyping.
Thursday, May 14, 2015
CollabRx, Affymetrix To Develop Analytical Tools For Integrated Clinical Cancer Panels
The overall objective of the partnership is to provide scientific knowledge for biomarker CNV profiles in cancer.
Wednesday, April 16, 2014
University of Bristol Collaborates with Affymetrix on Genotyping Arrays
Results from the array presented at the 2014 Plant and Animal Genome conference.
Wednesday, January 15, 2014
Affymetrix Reports 2013 First Quarter Results
Affymetrix, Inc. reported its operating results for the three months ended March 31, 2013.
Wednesday, May 01, 2013
Affymetrix and BioDiscovery Announce Software for Analysis of Whole Genome Copy Number Data
Generated from FFPE solid tumor samples for accelerating cancer translational research.
Thursday, April 11, 2013
Ingenuity Systems and Affymetrix Partner
Companies collaborate to eliminate microarray expression analysis bottleneck.
Monday, April 08, 2013
Affymetrix Announces Collaboration with Centre for Proteomic and Genomic Research (CPGR)
CPGR will provide gene expression and Axiom genotyping services to African researchers using GeneTitan® Multi-Channel (MC) Instrument.
Tuesday, November 20, 2012
Affymetrix and Singapore-based Start-up PathGEN Dx Sign Partnership
Agreement for diagnostic test development for pathogen detection.
Monday, August 27, 2012
Affymetrix Completes Acquisition of eBioscience Holding Company, Inc.
Acquisition expands Affymetrix’s addressable markets by more than $2.5 billion per year.
Thursday, June 28, 2012
Affymetrix Announces Proposed $105 Million Offering of Convertible Senior Notes Due 2019
Company expects to grant an option to purchase up to $10 million aggregate principal amount of additional notes.
Thursday, June 21, 2012
Affymetrix Announces Research Collaboration with MGH
Collaboration and licensing agreement to validate and develop new oncology biomarker tests.
Thursday, June 07, 2012
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
Promising Drug Combination for Advanced Prostate Cancer
A new drug combination may be effective in treating men with metastatic prostate cancer. Preliminary results of this new approach are encouraging and have led to an ongoing international study being conducted in 196 hospitals worldwide.
A Cellular Symphony Responsible for Autoimmune Disease
Broad Institute researchers have used a novel approach to increase our understanding of the immune system as a whole.
When it Comes to Breast Cancer, Common Pigeon is No Bird Brain
If pigeons went to medical school and specialized in pathology or radiology, they’d be pretty good at distinguishing digitized microscope slides and mammograms of normal vs. cancerous breast tissue, a new study has found.
Editing of LIMS Data Made Faster and More Efficient in Matrix Gemini
The latest version of the Matrix Gemini LIMS (Laboratory Information Management System) from Autoscribe Informatics now provides faster and more efficient editing of LIMS data by eliminating the need for a second editing screen.
University of Edinburgh, Selcia Achieve Key Milestones in Drug Development Program
Scientists from the University of Edinburgh, working with Selcia, have successfully passed the 20-month milestone targets of a 30-month Wellcome Trust SDDi £2.5 million project to design novel treatments for sleeping sickness.
Red Clover Genome to Help Restore Sustainable Farming
The Genome Analysis Centre (TGAC) in collaboration with IBERS, has sequenced and assembled the DNA of red clover to help breeders improve the beneficial traits of this important forage crop.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos