Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

NIST Focuses on Testing Standards to Support LOC Commercialization

Published: Wednesday, August 15, 2012
Last Updated: Wednesday, August 15, 2012
Bookmark and Share
Lab-on-a-chip devices are envisioned to one day revolutionize how laboratory tasks such as diagnosing diseases and investigating forensic evidence are performed.

However, a recent paper from the National Institute of Standards and Technology (NIST) argues that before LOC technology can be fully commercialized, testing standards need to be developed and implemented.

"A testing standard," explains NIST physical scientist and paper author Samuel Stavis, "defines the procedures used to determine if a lab on a chip device, and the materials from which it is made, conform to specifications." Standardized testing and measurement methods, Stavis writes, will enable MEMS (microelectromechanical systems) LOC manufacturers at all stages of production—from processing of raw materials to final rollout of products—to accurately determine important physical characteristics of LOC devices such as dimensions, electrical surface properties, and fluid flow rates and temperatures.

To make his case for testing standards, Stavis focuses on autofluorescence, the background fluorescent glow of an LOC device that can interfere with the analysis of a sample. Stavis states that multiple factors must be considered in the development of a testing standard for autofluorescence, including: the materials used in the device, the measurement methods used to test the device and how the measurements are interpreted. "All of these factors must be rigorously controlled for, or appropriately excluded from, a meaningful measurement of autofluorescence," Stavis writes.

Quality control during LOC device manufacturing, Stavis says, may require different tests of autofluorescence throughout the process. "There may be one measure of autofluorescence from the block of plastic that is the base material for a chip, another once the block has been fashioned into the substrate in which the functional components are embedded, and yet another as the final device is completed," Stavis says. "To manufacture lab on a chip devices with reliably low autofluorescence, accurate measurements may be needed at each stage."

Stavis also emphasizes that it is important not to confuse testing standards with product standards, and to understand how the former facilitates the latter. "A product standard specifies the technical requirements for a lab on a chip device to be rated as top quality," he says. "A testing standard is needed to measure those specifications, as well as to make fair comparisons between competing products."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Need for Better Characterized Genomes for Clinical Sequencing
A new study that assesses the accuracy of modern human-genome-sequencing technologies found that some medically significant portions of an individual’s DNA blueprint are situated in complex, hard-to-analyze regions that are currently prone to systematic errors.
Thursday, March 03, 2016
Vaccine Fridge Field Study ‘Opens Doors’ to New Standards
Recipients of an annual flu shot may be surprised to learn that there is currently no official standard for vaccine storage equipment in clinics, pharmacies, and other health providers’ offices – a potential problem, since vaccines need to be kept within strict temperature limits to remain viable.
Wednesday, February 24, 2016
Portable Kit Can Recover Traces of Chemical Evidence
A chemist at the National Institute of Standards and Technology (NIST) has developed a portable version of his method for recovering trace chemicals such as environmental pollutants and forensic evidence including secret graves and arson fire debris.
Wednesday, January 13, 2016
Forensic Facial Examiners Can Be Near Perfect
In what might be the first face-off of its kind, trained forensics examiners from the FBI and law enforcement agencies worldwide were far more accurate in identifying faces in photographs than nonexperts and even computers.
Wednesday, September 30, 2015
Contactless Fingerprint Technology is Coming
Quickly moving through security checkpoints by showing your hand to a scanner seems straight out of science fiction, but NIST is working with industry to bring fast, touchless fingerprint readers out of the lab and into the marketplace.
Tuesday, September 08, 2015
Determining the Age of Fingerprints
Watch the imprint of a tire track in soft mud, and it will slowly blur, the ridges of the pattern gradually flowing into the valleys. Researchers have tested the theory that a similar effect could be used to give forensic scientists a way to date fingerprints.
Wednesday, August 26, 2015
New Members of U.S National Commission on Forensic Science Announced
The U.S. Department of Justice (DOJ) and the U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) today announced six appointments to the National Commission on Forensic Science.
Friday, August 07, 2015
Giving Cancer a Deadly Fever
Heat may be the key to killing certain types of cancer, and new research has yielded unexpected results that should help optimize the design of magnetic nanoparticles that can be used to deliver heat directly to cancerous tumors.
Thursday, June 18, 2015
Center for Improving Statistical Analysis of Forensic Evidence
The U.S. Commerce Department’s National Institute of Standards and Technology has awarded Iowa State University up to $20 million over five years to establish a Forensic Science Center of Excellence focused on pattern and digital evidence.
Tuesday, June 09, 2015
Measuring Volumes of Key 'Lab on a Chip' Components
NIST found a combination of techniques to effectively measure microfluidic channels, achieving an accuracy of within 5 percent for both a channel's depth and its bottom's width.
Wednesday, April 22, 2015
NMR ‘Fingerprinting’ for Monoclonal Antibodies
Study by NIST researchers shows the use of NMR spectroscopy for measuring the structural congfiguration of monoclonal antibodies.
Thursday, April 16, 2015
Ultra-enriched Silicon Paves the Road to Quantum Computing
Using a relatively straightforward technique, a team of NIST researchers has created what may be the most highly enriched silicon currently being produced.
Wednesday, August 13, 2014
NIST, County Crime Lab Team Up on Ballistics Research
Partnership will contribute to a collection of topographic data from thousands of fired bullets and cartridge cases.
Tuesday, August 12, 2014
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."
Wednesday, July 23, 2014
NIST Names Members of Forensic Science Resource Committees
The new members, selected for their expertise in law, psychology and quality assurance, will serve on three advisory committees.
Thursday, July 17, 2014
Scientific News
Ketamine Metabolism Lifts Depression
NIH-funded team finds rapid-acting, non-addicting agent in mouse study.
Faster, Cheaper Way to Produce New Antibiotics
A novel way of synthesising a promising new antibiotic has been identified by scientists at the University of Bristol.
Process Contaminants in Vegetable Oils and Foods
Glycerol-based process contaminants found in palm oil, but also in other vegetable oils, margarines and some processed foods, raise potential health concerns for average consumers of these foods in all young age groups, and for high consumers in all age groups.
Known Genetic Risk Factors for Endometrial Cancer Doubles
An international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer, one of the most common cancers to affect women, taking the number of known gene regions associated with the disease to nine.
Improving Natural Killer Cancer Therapy
Vanderbilt University researchers discover transcription factor critical for NK cell expansion. Findings could lead to increased therapeutic efficacy.
Molecular Mechanism For Generating Specific Antibody Responses Discovered
Study could spur more ways to treat autoimmune disease, develop accurate vaccines.
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
It’s Now Easier To Go With The Flow
Rice University tool simplifies comparison of flow cytometry data for laboratories.
Autism, Cancer Share a Remarkable Number of Risk Genes
Researchers with the UC Davis Comprehensive Cancer Center, MIND Institute identify more than 40 common genes.
Number Of Known Genetic Risk Factors For Endometrial Cancer Doubled
An international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer, one of the most common cancers to affect women, taking the number of known gene regions associated with the disease to nine.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!