Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientist Awarded $1.9 Million to Study Food Intake and Metabolism

Published: Monday, August 20, 2012
Last Updated: Monday, August 20, 2012
Bookmark and Share
The award from the NIH will allow scientists from the Florida campus of The Scripps Research Institute to study pathways that regulate how we coordinate the timing of our desire for food throughout the day.

These pathways play a key role in maintaining the body’s balance between how much we eat and our metabolism and energy expenditure.

Andrew Butler, an associate professor at Scripps Research, is the principal investigator for the new four-year study.

The research focuses on the melanocortin-3 receptor (MC3R, a g-protein coupled receptor) in the central nervous system. The MC3R is one component of the central nervous melanocortin system, which normally responds to signals of nutrient intake. The actions of the central nervous melanocortin system involving MC3Rs are central to the regulation of our metabolism. Attenuated activity of this system has been implicated in a range of metabolic diseases, including obesity and insulin resistance (a precursor to diabetes).

“One function of the melanocortin system is to prevent obesity in humans,” he said, “and this system is therefore considered an attractive target for developing drugs against obesity and eating disorders. Unfortunately, very little is known about the functions of melanocortin-3 receptors.”

Butler’s ongoing research suggests that MC3Rs help synchronize our circadian rhythms (24-hour day-night cycles) with food intake. MC3Rs are also linked to the regulation of glucose production and insulin action during cycles of fasting and feeding.  

“Our goal for this new study is two-fold,” Butler said. “We want to identify the MC3R signaling pathways involved in regulating behaviors that anticipate feeding, and we want to look at pathways responsible for maintaining metabolic homeostasis.”

Beyond forming a better understanding of the functions of MC3R in the central nervous system, Butler said, the ultimate point of the research is to develop new and innovative approaches to prevent and treat metabolic and circadian-rhythm disorders.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Harnessing Nature’s Vast Array of Venoms for Drug Discovery
Scripps scientists have developed a method for rapidly identifying venoms.
Wednesday, May 25, 2016
Breakthrough Approach to Breast Cancer Treatment
Scripps scientists have designed a drug candidate that decreases growth of breast cancer cells.
Tuesday, May 24, 2016
Making Genetic Data Easier to Search
Scripps team streamlines biomedical research by making genetic data easier to search.
Tuesday, May 17, 2016
Potent Therapeutic 'Warheads' That Target Cancer Cells
Scripps scientists have developed molecular “warheads” that could be used to treat cancer.
Tuesday, May 17, 2016
Predicting Cell Changes that Affect Breast Cancer Growth
Researchers find small structural changes in a key breast cancer receptor that can predict cancer growth.
Tuesday, May 03, 2016
Secrets of a Deadly Virus Family Revealed
Scripps Research scientists uncover the glycoprotein structure of LCMV. The findings could guide development of treatments for Lassa fever.
Wednesday, April 27, 2016
First ‘Teenage’ HIV-Neutralizing Antibody Discovered
Scientists have studied the evolution of anti-HIV antibodies, with hopes of creating a vaccine to prevent AIDS.
Wednesday, April 06, 2016
Discovering 'Outlier' Enzymes
Researchers at TSRI and Salk Institute have discovered 'Outlier' enzymes that could offer new targets to treat type 2 diabetes and inflammatory disorders.
Saturday, April 02, 2016
Encouraging Foundation for Upcoming AIDS Vaccine Clinical Trial
Engineered vaccine protein binds key immune cells that exist in nearly everyone.
Tuesday, March 29, 2016
New Approach to Curbing Cancer Cell Growth
Using a new approach, scientists at The Scripps Research Institute (TSRI) and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.
Monday, March 14, 2016
Vaccine Against Dangerous Designer Opioids
With use of synthetic opioid "designer drugs" on the rise, scientists from The Scripps Research Institute (TSRI) have a new strategy to curb addiction and even prevent fatal overdoses.
Thursday, February 18, 2016
Potential Target for Treatment of Autism
Grant of $2.4 million will support further research.
Friday, October 02, 2015
Key Morphine Regulator Identified
The findings could lead to less addictive pain medications.
Thursday, September 24, 2015
$6 Million Awarded to Develop Alternative HIV/AIDS Vaccine
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded up to nearly $6 million from the Bill & Melinda Gates Foundation to develop a revolutionary HIV/AIDS alternative vaccine that has demonstrated great potential in animal models.
Thursday, September 24, 2015
Novel Role of Mitochondria in Immune Function Identified
Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
Monday, September 21, 2015
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Grant Supports Project To Develop Simple Test To Screen For Cervical Cancer
UCLA Engineering announces funding from Bill and Melinda Gates Foundation.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!