Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Scientist Awarded $1.9 Million to Study Food Intake and Metabolism

Published: Monday, August 20, 2012
Last Updated: Monday, August 20, 2012
Bookmark and Share
The award from the NIH will allow scientists from the Florida campus of The Scripps Research Institute to study pathways that regulate how we coordinate the timing of our desire for food throughout the day.

These pathways play a key role in maintaining the body’s balance between how much we eat and our metabolism and energy expenditure.

Andrew Butler, an associate professor at Scripps Research, is the principal investigator for the new four-year study.

The research focuses on the melanocortin-3 receptor (MC3R, a g-protein coupled receptor) in the central nervous system. The MC3R is one component of the central nervous melanocortin system, which normally responds to signals of nutrient intake. The actions of the central nervous melanocortin system involving MC3Rs are central to the regulation of our metabolism. Attenuated activity of this system has been implicated in a range of metabolic diseases, including obesity and insulin resistance (a precursor to diabetes).

“One function of the melanocortin system is to prevent obesity in humans,” he said, “and this system is therefore considered an attractive target for developing drugs against obesity and eating disorders. Unfortunately, very little is known about the functions of melanocortin-3 receptors.”

Butler’s ongoing research suggests that MC3Rs help synchronize our circadian rhythms (24-hour day-night cycles) with food intake. MC3Rs are also linked to the regulation of glucose production and insulin action during cycles of fasting and feeding.  

“Our goal for this new study is two-fold,” Butler said. “We want to identify the MC3R signaling pathways involved in regulating behaviors that anticipate feeding, and we want to look at pathways responsible for maintaining metabolic homeostasis.”

Beyond forming a better understanding of the functions of MC3R in the central nervous system, Butler said, the ultimate point of the research is to develop new and innovative approaches to prevent and treat metabolic and circadian-rhythm disorders.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Potential Target for Treatment of Autism
Grant of $2.4 million will support further research.
Friday, October 02, 2015
Key Morphine Regulator Identified
The findings could lead to less addictive pain medications.
Thursday, September 24, 2015
$6 Million Awarded to Develop Alternative HIV/AIDS Vaccine
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded up to nearly $6 million from the Bill & Melinda Gates Foundation to develop a revolutionary HIV/AIDS alternative vaccine that has demonstrated great potential in animal models.
Thursday, September 24, 2015
Novel Role of Mitochondria in Immune Function Identified
Scientists at The Scripps Research Institute (TSRI) have discovered a new role for an enzyme involved in cell death.
Monday, September 21, 2015
Scientists Make Strides in Therapy Preventing Addiction Relapse
Single Injection of Drug Candidate Prevents Meth Relapse in Animal Models.
Thursday, August 06, 2015
New Antibody Weapons Against Marburg Virus
A study has identified new immune molecules that protect against deadly Marburg virus, a relative of Ebola virus.
Tuesday, June 30, 2015
Team Led by TSRI Scientists Shows AIDS Vaccine Candidate Successfully ‘Primes’ Immune System
New research shows that an experimental vaccine candidate can stimulate immune activity necessary to prevent HIV infection.
Thursday, June 25, 2015
New Details of Potential Alzheimer’s Treatment Uncovered
Scientists from Florida’s Scripps Resarch Institute have uncovered suprising new details of potential Alzheimer’s treatment.
Wednesday, April 29, 2015
Search for Cancer Drug Candidates
Scripps Florida scientists awarded $1.2 million to find drug candidates that could treat a wide range of cancers.
Friday, April 10, 2015
Scripps Florida Scientists Win $1.5 Million Grant to Develop New Cancer Drugs
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $1.5 million grant from the National Institutes of Health (NIH) to develop drug candidates that could treat cancer and neurodegenerative disease.
Tuesday, March 24, 2015
Day-Night Cycles Linked to Mutations
TSRI scientists show that proteins critical in day-night cycles also protect cells from mutations.
Friday, March 13, 2015
More DNA & Extra Copies of Disease Gene in Alzheimer’s Brain Cells
Scientists at The Scripps Research Institute (TSRI) have found diverse genomic changes in single neurons from the brains of Alzheimer’s patients, pointing to an unexpected factor that may underpin the most common form of the disease.
Tuesday, February 24, 2015
Possible Neuron Killing Mechanism Behind Alzheimer’s and Parkinson’s Diseases Discovered
$1.4 million grant will enable team to follow up with search for drug candidates.
Tuesday, February 17, 2015
Microbes Prevent Malnutrition in Fruit Flies—and Maybe Humans, Too
Study shows that microbes play a critical role in nutritional disorders.
Friday, February 13, 2015
New Targets and Test to Develop Treatments for Memory Disorders
The study focuses on kinesin, a molecular motor protein that plays a role in the transport of other proteins throughout a cell.
Thursday, November 13, 2014
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos