Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Well-known Protein Reveals New Tricks

Published: Friday, September 07, 2012
Last Updated: Friday, September 07, 2012
Bookmark and Share
A protein called "clathrin," which is found in every human cell and plays a critical role in transporting materials within them, also plays a key role in cell division.

The discovery, featured on the cover of the Journal of Cell Biology in August, sheds light on the process of cell division and provides a new angle for understanding cancer. Without clathrin, cells divide erratically and unevenly-a phenomenon that is one of the hallmarks of the disease.

"Clathrin is doing more than we thought it was doing," said Frances Brodsky, DPhil, who led the research. Brodsky is a professor in the UCSF Department of Bioengineering and Therapeutic Sciences, a joint department of the Schools of Pharmacy and Medicine, and she holds joint appointments in Microbiology and Immunology, as well as Pharmaceutical Chemistry.

Protein essential for transportation in more than one route

Akin to a three-pronged building block in a child's construction set, clathrin can provide links to create larger complexes. When lots of these proteins are assembled together, they can form tough little cages into which cells packs many of their essential biological molecules-hormones, neurotransmitters, membrane proteins and other payloads that need to be transported throughout the cell.

Once thought to be solely involved in transport inside cells, scientists have uncovered more and more of the protein's hidden functions in the last half-dozen years, including some roles it plays in cell division.

For instance, they learned several years ago about its role in the function of "spindles." Normally when a cell divides, it forms a spindle by laying down tracks of structural proteins, and uses them as scaffolding to separate the cell's DNA (in the form of chromosomes) into two equal collections-one identical set of DNA for each of the new daughter cells. Scientists found that clathrin is involved in stabilizing these spindles.

Now, however, Brodsky and her colleagues have shown that clathrin does even more. They deleted clathrin from cells using a technique called RNA interference, which involves infusing in small genetic fragments that block the cell from making the clathrin. Doing so, Brodsky and her colleagues showed that clathrin stabilizes the structures in dividing cells known as centrosomes.

Tagged with fluorescent chemicals and viewed under a microscope, the centrosomes within a cell that is about to divide look like two glowing eyes peering through the dark. But without clathrin, the team determined, the eyes increase in number.

Brodsky and her colleagues traced this effect to a protein complex formed by one particular component of clathrin called CHC17, which directly stabilizes the centrosome and helps it mature. Deleting CHC17 or chemically inactivating it, led to cells with a strange appearance. These cells contained multiple, fragmented centrosomes instead of the normal two and built abnormal spindles.

This discovery may reveal pathways towards abnormalities of chromosome segregation associated with cancer, said Brodsky.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

‘Human-on-a-Chip’ Could Replace Animal Testing
Researchers are developing a “human-on-a-chip,” a miniature external replication of the human body, integrating biology and engineering with a combination of microfluidics and multi-electrode arrays.
Monday, June 13, 2016
Unveiling the Complexity of Mysterious Protein Folding
Imagine trying to reverse engineer a car when all you have is a finished product or a box full of parts — no instructions.
Wednesday, June 01, 2016
Study Identifies How Brain Connects Memories Across Time
UCLA Neuroscientists have boost ability of aging brain to recapture links between related memories.
Tuesday, May 31, 2016
Transcription Factor Isoforms Implicated in Colon Diseases
UC Riverside study explains how distribution of two forms of a transcription factor in the colon influence risk of disease.
Thursday, May 19, 2016
An E.coli Detector May be in Your Hands Soon
Hand-held device that can be used to detect a variety of pathogens—including foodborne pathogens like E. coli—at all stages in the food supply chain, from fields to restaurants may be available soon.
Monday, May 16, 2016
Fructose Alters Hundreds of Brain Genes
UCLA scientists report that diet rich in omega-3 fatty acids can reverse the damage.
Tuesday, April 26, 2016
Study Yields the Key to Effective Personalized Medicine
A team of UCLA bioengineers and surgeons has taken a major step toward making personalized medicine a reality.
Monday, April 11, 2016
Tracking RNA in Live Cells
Technique may open doors to new treatments for many conditions, from cancer to autism.
Friday, March 18, 2016
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Monday, February 08, 2016
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Monday, February 08, 2016
Toxic Pollutants Found in Fish Across the World's Oceans
Scripps researchers' analysis shows highly variable pollutant concentrations in fish meat.
Friday, January 29, 2016
Key Enzyme in Pierce’s Disease Grapevine Damage Uncovered
UC Davis plant scientists have identified an enzyme that appears to play a key role in the insect-transmitted bacterial infection of grapevines with Pierce’s disease, which annually costs California’s grape and wine industries more than $100 million.
Wednesday, January 13, 2016
Science Magazine Names CRISPR ‘Breakthrough of the Year’
In its year-end issue, the journal Science chose the CRISPR genome-editing technology invented at UC Berkeley 2015’s Breakthrough of the Year.
Monday, December 21, 2015
Genome Sequencing May Save California's Legendary Sugar Pine
The genome of California’s legendary sugar pine, which naturalist John Muir declared to be “king of the conifers” more than a century ago, has been sequenced by a research team led by UC Davis scientists.
Thursday, December 17, 2015
Cellular “ORACLs” to Aid Drug Discovery
New approach for finding therapeutics is inspired by face-recognition software.
Wednesday, December 16, 2015
Scientific News
Breakthrough Flu Vaccine Inhibited by Pre-existing Antibodies
Universal truths – how existing antibodies are sabotaging the most promising new human flu vaccines.
New Medication Shows Promise Against Liver Fibrosis in Animal Studies
Liver fibrosis is a gradual scarring of the liver that puts people at risk for progressive liver disease and liver failure.
Raw Eggs Deemed Safe to Eat
A report published today by the Advisory Committee on the Microbiological Safety of Food (ACMSF) into egg safety has shown a major reduction in the risk from salmonella in UK eggs.
Monitoring TTX Toxin in Shellfish
In a number of small studies, mussels and oysters from the eastern and northern part of the Oosterschelde in Holland were found to contain tetrodotoxin (TTX).
Gene Terapy for Muscle Wasting Developed
New gene therapy could save millions of people suffering from muscle wasting disease.
NIH Begins Yellow Fever Vaccine Trial
NIH has initiated an early-stage clinical trial of a vaccine to protect against yellow fever.
Gene-Editing 'Toolbox' Targets Multiple Genes Simultaneously
Researchers have designed a system that modifies, or edits, multiple genes in a genome at once while minimising unintentional effects.
Detecting Alzheimer's with Smell Test
Odour identification test may offer low-cost alternative for predicting cognitive decline and detecting early-stage Alzheimer’s disease.
Antibody Drug Shows Promise in HIV Treatment
Researchers are a step closer to an alternative HIV treatment that has the potential for lasting effects and less frequent dosing.
Testing Nanoparticle Drug Delivery in Dogs
Scientists have tested a nanoparticle drug delivery against bone cancer in dogs with promising results.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!