Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

UC Davis Receives $9.3 Million Grant for Metabolomics Center

Published: Monday, September 10, 2012
Last Updated: Monday, September 10, 2012
Bookmark and Share
The new center will bring together existing UC Davis service facilities in mass spectrometry, nuclear magnetic resonance and imaging.

With a $9.3 million startup grant from the National Institutes of Health, the University of California, Davis, has announced plans to open the West Coast Metabolomics Center, a high-tech consortium of research and service laboratories that will help scientists better understand and develop more effective treatments for complex diseases like diabetes, cancer and atherosclerosis.

The facility, which will be housed within the UC Davis Genome Center, will celebrate its grand opening Oct. 8 with a mini-symposium featuring UC Davis and regional scientists, and corporate supporters.

Metabolomics is a new field that looks at the biochemical changes taking place in living cells during metabolism. The West Coast Metabolomics Center at UC Davis will use more than 30 mass spectrometers — instruments for analyzing chemical structures — to target thousands of different molecules produced in cells, allowing researchers to look at changes taking place at specific times and under specific environmental conditions.

“The NIH recognizes metabolism as a very important part of human physiology and disease processes,” said Oliver Fiehn, professor of molecular and cellular biology and director of the new center. “When you analyze metabolism, you can tell the state of the body at the onset and during the progression of diseases ranging from cardiovascular disease to cancer.”

It will help researchers throughout the western U.S. with small grants for annual pilot and feasibility studies, provide courses, statistics and bioinformatics services, and perform metabolomic analyses on a fee-for-service basis. The center is designed to be self-sustaining within five years.

One of researchers who plans to use the new center is UC Davis Professor Bruce German, who studies lipid metabolism, especially in milk production, in the Department of Food Science and Technology.

“This new center shows the effects of the university’s long-term investments into biochemistry and genomics,” German said.

Juvenile diabetes
One of the center's first big projects will be as part of a large international study, led by the NIH, to look for environmental causes of childhood diabetes. Juvenile, or Type 1 diabetes is an autoimmune disease that causes the body to destroy pancreatic cells that produce insulin, and people with the disease must inject insulin regularly in order to survive.

Called the TEDDY study — The Environmental Determinants of Type 1 Diabetes in the Young — the project will track nearly 8,000 children over a three-year period to try to identify factors such as infections, diet, stress or other conditions that may trigger the disease.

“We know that children who get Type 1 diabetes all have certain gene signatures, but most children with those same genes don’t get the disease,” Fiehn said. “Researchers now believe there’s an environmental trigger — something that activates those genes and causes the disease. Metabolomics is a way to try to identify those environmental triggers by seeing what’s happening inside the cells over time. In addition, metabolomics is a chemical screening tool that might find further environmental cues, including pollutants.”

The West Coast Metabolomics Center will analyze blood samples taken from children every three months during the study period, providing data to researchers that may help them identify a single factor or series of factors that trigger the disease. The TEDDY consortium will pay more than $1.5 million for the services provided by the new center.

Individualized medicine
Another promising aspect of metabolomics research is creating individualized treatments for people with certain diseases, or choosing the best available treatment for a patient.

Metabolomics could be used to determine the best dose of treatment for a patient. People with higher metabolisms may need higher doses of drugs than people with lower metabolisms, for example.

"Understanding metabolomics and disease response will help scientists to develop new therapeutic strategies," said Professor Ralph de Vere White, director of the UC Davis Comprehensive Cancer Center. "This metabolomics research center will allow the UC Davis Comprehensive Cancer Center to advance this exciting area in cancer research, more deeply understand underlying mechanisms, and improve treatment options for patients."

The West Coast Metabolomics Center at UC Davis has received instrumentation support from mass spectrometry equipment companies Agilent Inc. and LECO Corporation.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Local Microbes Can Predict Wine’s Chemical Profile
Regionally distinctive groups of bacteria and fungi, associated with local climate and environmental conditions, may leave a very specific “fingerprint” on a wine’s chemical composition, report University of California, Davis, researchers who collaborated on a new study with two Napa Valley wineries.
Wednesday, June 15, 2016
Autism, Cancer Share a Remarkable Number of Risk Genes
Researchers with the UC Davis Comprehensive Cancer Center, MIND Institute identify more than 40 common genes.
Wednesday, May 04, 2016
Fueling Infant Gut Microbes
UC Davis researchers have shown that an enzyme produced by beneficial microbes in babies’ intestines is able to harvest specific sugar compounds from human breast-milk and cow’s milk.
Monday, April 18, 2016
Reprogramming Scorpion Venom
‘Twist of nature’ neutralizes toxin.
Monday, April 18, 2016
Gene Blocking Lettuce Germination Also Regulates Flowering Time
Study finds that DOG1 gene functions by acting on certain microRNAs, and may help adapt the timing of seed dormancy and flowering to environmental conditions.
Wednesday, March 30, 2016
Team Finds Early Inflammatory Response Paralyzes T Cells
Findings could have enormous implications for immunotherapy, autoimmune disorders, transplants and other aspects of immunity.
Thursday, August 20, 2015
UC Davis to Establish Food Safety Center in China
Officials from the city of Zhuhai, China, and the University of California, Davis, have signed a memorandum of understanding to establish the World Food Center-China.
Monday, June 01, 2015
Nanomaterials In Sunscreens And Boats Leave Marine Life Vulnerable
Study shows that sea urchin embryos are more vulnerable to toxins when exposed to nanomaterials.
Thursday, May 14, 2015
Milk Protein Comparison Unveils Nutritional Gems For Developing Babies
The study revealed the first comprehensive macaque milk proteome and newly identified 524 human milk proteins.
Tuesday, March 17, 2015
Keck Foundation Grant Awarded to UC Davis Researcher
Grant will help fund biomedical project, "In Vivo 3D Imaging Using Bioluminescent Gene Reporters and MRI."
Monday, March 10, 2014
High Good and Low Bad Cholesterol Levels are Healthy for the Brain
Study suggests a potential new approach to lowering the prevalence of Alzheimer's disease.
Friday, January 03, 2014
UC Davis "Lab on a Chip" Measures Heart Disease Risk
New test mimics artery conditions, detects inflammatory cells linked with atherosclerosis and myocardial infarction.
Thursday, August 08, 2013
Cancer Drug Unties Knots in the Chromosome that Causes Angelman and Prader-Willi Syndromes
Researchers have identified how and where in the genome a cancer chemotherapy agent acts on and ‘un-silences’ the epigenetically silenced gene that causes Angelman syndrome.
Thursday, August 08, 2013
UC Davis Helps Global Team Sequence Chickpea Genome
An international team of scientists has sequenced the genome of the chickpea, a critically important crop in many parts of the world, especially for small-farm operators in marginal environments of Asia and sub-Saharan Africa.
Wednesday, January 30, 2013
Sequencing of 100,000 Pathogens to Help Solve Foodborne Outbreaks
New collaboration of Federal agencies with UC Davis and Agilent Technologies.
Friday, August 24, 2012
Scientific News
Shedding Light on HIV Vaccine Design
Broadly speaking - Mathematical modelling of host-pathogen coevolution sheds light on HIV vaccine design.
AACC 2016 Sees Clinical Chemistry Labs Drive Precision Medicine Offerings
Biomarker assays to enable precision medicine and risk assessment, mass spec-based tests designed for use in clinical labs large and small, and liquid biopsy technology captured the spotlight at the AACC annual meeting.
Automated Patch Clamping Trends
Learn more about current practices, preferences and metrics in ion channel drug screening using APC technology.
Lab-on-a-Stick: Miniaturised Clinical Testing For Fast Detection Of Antibiotic Resistance
A portable power-free test for the rapid detection of bacterial resistance to antibiotics has been developed by academics at Loughborough University and the University of Reading.
Genetic Ancestry of Cultivated Strawberry Unravelled
UNH scientists constructed a linkage map of the seven chromosomes of the diploid Fragaria iinumae, which allows them to fill in a piece of the genetic puzzle about the eight sets of chromosomes of the cultivated strawberry.
Progress In Vaccination Against Vespid Venom
Researchers at the Helmholtz Zentrum München and the Technical University Munich have presented a method which facilitates a personalised procedure for wasp allergy sufferers.
New Drug Target for Inflammatory Disorders
Penn study finds enigmatic molecules maintain equilibrium between fighting infection and inflammatory havoc.
Breast Cancer Cells Found To Switch Molecular Characteristics
Spontaneous interconversion between HER2-positive and HER2-negative states could contribute to progression, treatment resistance in breast cancer.
Mechanisms of Calcium Blockers
Researchers describe how the fundamental mode of action of two distinct chemical classes of calcium channel blockers differs.
Some Breast Cancer Patients With Low Genetic Risk Could Skip Chemotherapy
Genetic test can help predict survival and guide treatment options.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!