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Analysis of Immune Responses in Patients Treated With Vacc-4x Supports Further Development

Published: Wednesday, September 12, 2012
Last Updated: Wednesday, September 12, 2012
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Data presented at largest global scientific conference focused exclusively on AIDS vaccine research.

The comprehensive analysis of the Vacc-4x phase II study is providing important insight for further development towards commercialization.

Researchers from the Vaccine Immunotherapy Center at the Lausanne University Hospital presented today immunological data from the phase II study with Vacc-4x during an oral session at the AIDS Vaccine 2012 conference in Boston. Vacc-4x is an investigational vaccine to treat patients with HIV, developed by Bionor Pharma. The data from immunological analysis, which was carried out at the Swiss laboratory, was presented by Kim Ellefsen-Lavoie, CTU (Clinical trials unit) Coordinator, Vaccine and Immunotherapy Center, University Hospital, Lausanne, Switzerland.

The data show that patients carrying a genetic variant (HLA B-35) associated with rapid disease progression of untreated HIV infection are just as likely to respond to Vacc-4x as other patients. This supports Bionor's intention for the vaccine to function across broader patient populations. Complete findings from the analysis will be submitted for publication.

AIDS Vaccine 2012 webcasts all sessions for viewing and archiving within 24 hours of their presentation. Webcast will be available on this page:

http://www.vaccineenterprise.org/conference/2012/program/webcasting

"Immunological data from the phase II study with Vacc-4x are providing insight on how this therapeutic vaccine could lead to the observed reduction in viral load," said Professor Giuseppe Pantaleo, MD, Chief of the Division of Immunology and Allergy, University Hospital, Lausanne, Switzerland. "The results from this study will be valuable for the further development towards a potentially new class of HIV treatment and combination therapies."


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