Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Melbourn Scientific Announces First Nasal Device Testing Lab at ICSE

Published: Thursday, September 20, 2012
Last Updated: Wednesday, September 19, 2012
Bookmark and Share
Service offers GMP analysis of droplet size, particle characterization, spray pattern and plume geometry.

The multiple benefits of a nasal spray has triggered a boom in product development activity generating greater demand for Melbourn Scientific’s expertise in formulation analysis and performance testing.

In response the company has created a dedicated laboratory to provide GMP testing of nasal device performance, the first in Europe to offer such a comprehensive service.

Mark Hammond, CEO of Melbourn Scientific says: “We predicted a few years ago that nasal delivery of compounds would increase as companies realized the benefits of this route. A nasal device offers a user friendly, painless, non-invasive route for drug administration.

“We are now seeing evidence of continued growth and that clients recognize the advantages of working with partners that have expertise in this area of drug delivery and understand the formulation and analytical challenges that it brings.

The portfolio of nasal spray services offered by Melbourn includes: nasal device performance testing, droplet size and distribution analysis, spray pattern and plume geometry analysis.

The new laboratory was included within a recent FDA inspection, which the company passed with ‘no significant deficiencies noted and no 483s issued’.

“The high surface area in the nasal cavity provides drugs with direct access to the systemic circulation providing rapid onset of action. This route also avoids any degradation from first pass metabolism, which means lower doses can be given reducing the possibility of unwanted side effects.”

The nasal cavity has a large surface area and high permeability, and the location of lymphoid tissue at the back of the nasal cavity offers rapid transport into the systemic circulation.

The olfactory region at the top of the nasal cavity is of interest for the treatment for age-associated diseases such as Alzheimer’s, as it allows rapid absorption into the central nervous system.

The nasal route can also enhance performance for a wide range of treatments from the instant relief of panic attacks through to needle-free vaccinations.

However, the challenge of a nasal delivery device is to get the particle size right in order to ensure that the drug is deposited within the nasal passages and not the lungs or gastro-intestinal tract. This is where a comprehensive testing regime is beneficial.

Mark explains, “Depending upon the drug and device properties there are a number of considerations for the formulation, here at Melbourn Scientific we have developed a range of screening tools to enable us to fast track formulation development of the product from simple solutions, through suspensions to dry powder blends using a wide range of excipients.

“Our formulation development is supported by standalone testing services with significant investment in specialist equipment. The new lab will make this available as a comprehensive service.”

Equipment includes: the Malvern Spraytec, which is designed to capture information about both pulsed spray and continuous spray events, Morphologi G3 an optical imaging tool that provides more information about individual particles giving data about their size, shape and solidity and the new Proveris’s SprayVIEW, a FDA accepted spray pattern and plume geometry analysis service.

Melbourn Scientific has also appointed a new business development executive Liz Parkhouse to provide a point of contact for the nasal spray testing service. She will be at ICSE to talk to visitors.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Melbourn Scientific Rises Above Helium Shortage
Hydrogen used for gas chromatographic methods to avoid the issues around uncertain supply and the increased costs of helium.
Monday, September 24, 2012
European CRO Offer FDA Approved Service
Melbourn first to offer FDA approved spray pattern and plume geometry analysis.
Monday, August 27, 2012
Melbourn Scientific Expands its Dissolution Testing Service
The development of a new generation of pharmaceuticals that target specific areas of the body has created challenges for dissolution testing.
Wednesday, June 28, 2006
Scientific News
Open Source Seed Initiative – A Welcome Boost to Global Crop Breeding
A team of plant breeders, farmers, non-profit agencies, seed advocates, and policymakers have created the Open Source Seed Initiative.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Implementation Science Approaches to Reduce Mother-to-Child HIV Transmission
The NIH study will investigate best practices to ease major disease burden in Sub-Saharan Africa.
Tough New Hydrogel Hybrid Doesn’t Dry Out
Water-based material could be used to make artificial skin, longer-lasting contact lenses.
New CAR T Cell Therapy Using Double Target Aimed at Solid Tumors
Researchers at Penn University have described how antibody, carbohydrate combination could apply to range of cancer types.
Lasers Carve the Path to Tissue Engineering
A new technique, developed at EPFL, combines microfluidics and lasers to guide cells in 3D space, overcoming major limitations to tissue engineering.
Link Between Canned Food, BPA Exposure Revealed
New Stanford research resolves the debate on the link between canned food and exposure to the hormone-disrupting chemical known as Bisphenol A, or BPA.
Portable Test Rapidly Detects Zika
To better diagnose and track the disease, scientists are now reporting a new $2 test that in the lab can accurately detect low levels of the virus in saliva.
Erasing Unpleasant Memories with a Genetic Switch
Researchers from KU Leuven and the Leibniz Institute for Neurobiology have managed to erase unpleasant memories in mice using a 'genetic switch'.
Unidentified Spectra Detector
New algorithm clusters over 250 million spectra for analysis, such that millions of unidentified peptide sequences can be recognised.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!