Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Innovation May Mean Collaborations for Drug Development in Future

Published: Wednesday, September 26, 2012
Last Updated: Wednesday, September 26, 2012
Bookmark and Share
Research collaborations and shared data will mark a change in the fiercely competitive pharmaceutical world, states a new report by healthcare experts GBI Research.

The new report states that academics, industry giants, regulators and patients’ organizations must work together in collaborative research projects in order for modern medicine to flourish.

Over the past decade, the number of New Drug Applications (NDAs) and Biologics License Applications (BLAs) approved by the US Food and Drug Administration (FDA) has fallen steadily, despite ever-increasing R&D expenditure. This gap between investment and success has led the pharmaceutical industry to rethink its business strategies, with industry professionals now working together in order to explore improved pathways for drug discovery and development.

Collaboration and open innovation through Public-Private Partnerships (PPPs) enables research that would not be possible for companies to undertake individually. The consortia tackle precompetitive research – fields of activity in which large companies agree to collaborate and invest in jointly, despite their rivalry in the drug market. Most companies agree that disease biology is a precompetitive science, but that once disease targets are identified, research becomes competitive. These projects aim to eliminate duplication of research, which would waste funding and resources, and also develop competition for samples and clinical trial participation within a single patient population.

The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a huge PPP, funded by the National Institutes of Health as well as private contributions from pharmaceutical partners through the Foundations for National Institutes of Health. Alzheimer’s disease is difficult to target, as it can progress for many years before symptoms become evident. The path of disease progression is unclear, and clinical trials for any new drug have to be very lengthy, and the failure of a drug to demonstrate efficacy represents both a huge loss of investments for pharma companies, and an ongoing lack of treatment options for patients.

The initiative has produced results which have fundamentally challenged the way in which clinical trials in Alzheimer’s disease should be conducted. Previously, the length of time over which the disease can progress without symptoms was not fully appreciated, and it has become clear that anti-amyloid treatments under investigation may prove far more effective in patients with the disease at an earlier stage than those currently included in clinical trials.

The ADNI represents one of the earliest large PPPs of its type, and stakeholders worked together to decide how to manage data and intellectual property. The decision to place all data into the public domain ensured there were no intellectual property issues, and opened the newly discovered research up to the world. Though is it still uncertain how commercial companies will deal with public access to their research, increased data leveraging undoubtedly makes more sense in the eyes of a scientist or patient.

The ADNI PPP has created a sense of shared responsibility in understanding Alzheimer’s disease and has improved the landscape for clinical research in the future. This could represent a major change to the way in which pharmaceuticals are researched and value created, setting the stage for future collaborations.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Global Biosimilars Market Value Could Hit $55 Billion by 2020, says GBI Research
Promising pipeline in active development and government efforts to reduce healthcare spending.
Thursday, July 02, 2015
Big Pharma Embraces Biologics
Increased uptake of biologics boosts API revenues and promote growth in the biopharmaceutical market.
Friday, November 30, 2012
Biologics and Stem Cell Research Boost the Cell Culture Market
Cell culture market expected to grow at a CAGR of 9.3% between 2011 and 2018.
Thursday, November 15, 2012
Outsourcing in Asia to Shrink Japan’s Revenue Share
Pharma’s interest in outsourcing, combined with rising industrialization in India and China, will mark a drop in Japan’s share of the continent’s revenue.
Tuesday, November 06, 2012
‘Tis the Season to Be Sniffly - Seasonal Influenza Boosts Vaccines Market
Acute viral respiratory infection influenza, or flu, strikes every winter, and several nations are preparing to tackle this illness through dedicated healthcare schemes, states a new report by healthcare experts GBI Research.
Monday, October 22, 2012
World Awaits Biosimilars Boom
Biosimilars set to take a sizable chunk of the global biopharmaceuticals market by 2020, new report predicts.
Thursday, October 04, 2012
Struggling Pharma Companies to Outsource Clinical Trial Research
Falling revenue in some healthcare sectors means companies are making huge efforts to reduce R&D expenditure and increase profitability.
Monday, April 23, 2012
Cost of Antivirals for HIV/AIDS Set to Increase
Antiviral drugs become expensive due to the launch of new combination therapies.
Friday, April 06, 2012
Scientific News
Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
Playing 'Tag' with Pollution lets Scientists See Who's It
Using a climate model that can tag sources of soot from different global regions and can track where it lands on the Tibetan Plateau, researchers have determined which areas around the plateau contribute the most soot — and where.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
High-Resolution 3D Images Reveal the Muscle Mitochondrial Power Grid
NIH mouse study overturns scientific ideas on energy distribution in muscle.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Paving the way to Better Ovarian Cancer Diagnosis
Aïcha BenTaieb will present her invention for automated identification of ovarian cancer’s many subtypes at an international conference this fall.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!