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Application of MALDI-TOF MS for Discrimination of Laboratory-Derived Antibiotic-Resistant Bacteria

Published: Monday, October 22, 2012
Last Updated: Monday, October 22, 2012
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In this study researchers from Musashino University examine the ability of MALDI-TOF MS to discriminate laboratory-derived antibiotic-resistant bacterial strains of known genetic origin was examined.

A computer-based cluster analysis of spectral data successfully discriminated the majority of single- as well as multiple-antibiotic-resistant Escherichia coli strains examined. Cluster analysis of Staphylococcus aureus strains with different levels of novobiocin resistance showed that as the degree of resistance increased similarity to the wild-type strain decreased. These results demonstrate that MALDI-TOF MS is capable of discriminating antibiotic-resistant bacterial strains and may have potential for differentiating bacterial strains with varying degrees of antibiotic-resistance.

The article is published online in Biological & Pharmaceutical Bulletin and is free to access. 

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