Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

A Protein's Role in Helping Cells Repair DNA Damage

Published: Tuesday, November 06, 2012
Last Updated: Tuesday, November 06, 2012
Bookmark and Share
A new study elucidates the role that a protein called TFIIB plays in supporting the activity of p53, a protein that helps suppress tumors.

In a new study, University at Buffalo scientists describe the role that a protein called TFIIB plays in helping cells repair DNA damage, a critical function for preventing the growth of tumors.
The research appeared online on Oct. 30 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition.

TFIIB, short for "transcription factor II B," is a protein that binds to DNA in cells to initiate the process of transcription, which is critical for building new proteins.

When DNA damage occurs, TFIIB is altered in a way that halts general transcription, enabling a cell to give priority to repair, the researchers found. With the shut-down in effect, cells are able to prioritize the important functions carried out by a tumor-suppressing protein called p53, said lead author Jayasha Shandilya, a postdoctoral researcher in UB's Department of Biological Sciences.

"P53 is a very important protein in humans and other multicellular organisms," Shandilya said. "It is called the 'guardian of the genome' because it helps maintain the stability of the genome."

About half of cancer cases involve a mutation or deletion of the p53 gene. When DNA is damaged, it activates p53, which not only stimulates the DNA repair pathway, but also triggers the synthesis of proteins that stop cells from dividing before problems are fixed, she said. In cases where the damage is irreparable, p53 initiates apoptosis, a process of programmed cell death.

In PNAS, Shandilya and colleagues report that for normal transcription to occur, TFIIB must undergo a process called phosphorylation, in which a phosphate group is attached to the protein.

But when the scientists studied cells treated with DNA damaging agents, they found that TFIIB was dephosphorylated, preventing general transcription and enabling the cells to focus resources on helping p53 carry out its tumor suppressing functions. In essence, p53 can bypass the need for TFIIB phosphorylation to activate transcription of its target genes, which are vital for DNA damage response.

Shandilya's colleagues on the PNAS paper are Yuming Wang, currently working at Cancer Research UK, and Stefan Roberts, assistant professor of biological sciences. Roberts oversaw the study, with funding from the National Institute of General Medical Sciences, one of the National Institutes of Health.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Technique for Studying Cellular Interfaces
The method, used to study cells involved in myelination, provides “a glimpse into the social life of cells” and boosts understanding of myelin diseases such as MS and Krabbe’s leukodystrophy.
Monday, September 21, 2015
E. Coli Can Be Transformed into Antibiotic Factories
Scientists have engineered E.coli to generate new varieties one of the most commonly used antibiotics, Erythromycin.
Wednesday, June 03, 2015
A Hybrid Vehicle That Delivers DNA
University at Buffalo researchers are developing new technology to improve DNA vaccines. The new transport system for DNA vaccines could help treat HIV, malaria, HPV and other major illnesses.
Thursday, November 27, 2014
How ‘Bad’ Cholesterol Causes Atherosclerosis in Humans: Stem cells play a Key Role
Study translates to humans a finding previously shown in lab animals that could lead to new therapy to use with statins or in place of them.
Monday, September 30, 2013
Clues to Autoimmune Conditions are Revealed by Genomic Analysis of a Skin Disease
UB researchers’ findings about Pemphigus vulgaris reveal a novel protective mechanism in at-risk individuals who remain healthy.
Monday, September 30, 2013
Nanotechnology Identifies Peptide "Fingerprint" in both Forms of ALS
A nanospray emitter developed by University at Buffalo chemist has identified a common molecular signature in familial and sporadic forms of ALS.
Wednesday, September 05, 2007
Engineered Blood Vessels Function like Native Tissue
Researchers says that blood vessels that have been tissue-engineered from bone marrow adult stem cells may serve as a patient's own source of new blood vessels.
Wednesday, July 11, 2007
Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
COPD Linked to Increased Bacterial Invasion
Persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!